Prevalence and Risk Factors for Anal Human Papillomavirus Infection in Human Immunodeficiency Virus–Positive Men Who Have Sex with Men

Combes, Jean‐Damien; Lion, A; Didelot, Jean-Michel; Fléjou, Jean‐François; Arvieux, Cédric; Canestri, Ana; Clifford, Gary M.; Jd, Combes; Costes-Martineau, Valérie; Grande, Jean Del; Didelot, J-M; Etienney, Isabelle; Falguières, Michaël; Ferry, Tristan; Fischer, Hugues; Flejou, JF; Heard, Isabelle; Henno, Sébastien; Hoyau, N; Landon, M; Laude, Hélène; Breton, F. Le; Lesage, A-C; Maincent, G; Marchand, Lucie; Njatonirina, H; Patey, O.; Sanchez, V Petrov; Pialoux, Vincent; Piroth, Lionel; Poizot‐Martin, Isabelle; Ressiot, E.; Radenne, Sylvie; Reynes, Jacques; Siproudhis, L.; Tamalet, Catherine; Tattevi, Pierre

doi:10.1093/infdis/jiy059

Cited by 35 publications

(40 citation statements)

References 27 publications

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“…All individuals with an HSIL harbored an HR HPV infection with the exception of 1 HIV‐infected patient who was positive for possibly carcinogenic HPV‐53. These results are consistent with those reported in a recent French multicenter study of HIV‐infected MSM and in a cross‐sectional study of HIV‐infected men recruited in Taiwan …”

Section: Discussionsupporting

confidence: 92%

“…All individuals with an HSIL harbored an HR HPV infection with the exception of 1 HIV-infected patient who was positive for possibly carcinogenic HPV-53. These results are consistent with those reported in a recent French multicenter study of HIV-infected MSM 35 and in a cross-sectional study of HIV-infected men recruited in Taiwan. 36 We also found that the detection of HPV-16/18, the most prevalent genotypes in anal cancer, 37 increased with the severity of the cytological lesions in both study groups, and there was a peak in HSILs, which were HPV-16/18positive in 50% to 67% of the cases.…”

Section: Cancer Cytopathologysupporting

confidence: 92%

“…The Linear Array HPV genotyping test (Roche Diagnostics) was used to assess the presence of HPV DNA, as previously described. 21,22 This assay allows the detection of 37 HPV genotypes (ie, 6,11,16,18,26,31,33,35,39,40,42,45,51,52,53,54,55,56,58,59,61,62,64,66,67,68,69,70,71,72,73,81,82,83,84, IS39 [HPV-82 subtype], and CP6108 [HPV-89]).…”

Section: Hpv-dna Testingmentioning

confidence: 99%

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Anal cytological lesions and HPV infection in individuals at increased risk for anal cancer

Donà

Benevolo

Latini

et al. 2018

Cancer Cytopathology

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The prevalence of anal cytological lesions is high in MSM, even in HIV-infected individuals treated with combined antiretroviral therapy. In these subjects, HSILs occur more frequently and at a younger age in comparison with HIV-uninfected counterparts. Specific diagnostic procedures should be implemented to manage individuals at increased risk for anal cancer with an abnormal anal Papanicolaou test. Cancer Cytopathol 2018. © 2018 American Cancer Society.

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Section: Discussionsupporting

confidence: 92%

Section: Cancer Cytopathologysupporting

confidence: 92%

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Anal cytological lesions and HPV infection in individuals at increased risk for anal cancer

Donà

Benevolo

Latini

et al. 2018

Cancer Cytopathology

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“…As chronic HPV infections in particular with multiple and high‐risk HPV represent a risk factor for AIN and anal carcinoma, subjects were clinically examined for signs of an HPV infection such as condylomata acuminata . Anal condyloma was significantly associated with abnormal screening results ( P = 0.045).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of anal carcinoma screening in male and female HIV patients at an interdisciplinary HIV therapy centre

Todorova

Schwierzeck

Turek

et al. 2019

Acad Dermatol Venereol

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Background Incidence of anal carcinoma is increased in people living with HIV (PLWH). Due to the improved life expectancy in PLWH, identifying appropriate prevention strategies for non‐AIDS‐defining cancer types such as anal carcinoma has become a priority in managing PLWH today. Objective We aimed to evaluate anal cytology assessment as screening tool for anal dysplasia and/or carcinoma in PLWH, regardless of gender or sexual orientation. Additionally, we investigated the correlation between cancer risk factors and abnormal screening results in our patient cohort. Methods People living with HIV from the Interdisciplinary HIV Centre of the University Hospital rechts der Isar in Munich, Germany (IZAR), were screened for anal carcinoma by single cytobrush examination and anal Papanicolaou (PAP) smear assessment from 2013 to 2015. Patients with abnormal PAP smear result were offered a follow‐up examination after 12 months. Differences between two groups were tested for statistical significance using Student's t‐test and Mann–Whitney U‐test, as appropriate. Results In total, 101 PLWH were included. 26.7% of subjects (n = 27) were PAP IIID, and 9.9% (n = 10) were PAP IVa. Seven female subjects had an abnormal finding at screening. Smoking was significantly associated with abnormal findings at screening (P = 0.005). In addition, our study found an association between sexually transmitted infections (STI) and anal dysplasia. Condylomata acuminata were increased in subjects with PAP IIID/PAP IVa (P = 0.045). Reactive syphilis serology was found to be significantly associated with abnormal screening results (P = 0.016), respectively. Conclusion Our results demonstrate that smoking and two common STIs, condylomata acuminata and syphilis, are risk factors associated with advanced anal intraepithelial neoplasia (AIN) stages in our PLWH cohort. While further analysis is needed to determine diagnostic guidelines concerning AIN in PLWH, these results suggest that interdisciplinary lifestyle prevention strategies are required to reduce the risk factors for AIN in PLWH in an outpatient setting.

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“…In terms of HPV types, the most common types of high-risk genital HPV among HIV seropositive MSM in Taiwan were HPV16 (5.9%), HPV51 (7.9%) and HPV52 (7.2%) 20 . In Western countries, the most common types was HPV16, with a prevalence of 29.0% 27 . However, the prevalence of HPV52 was around 10% 7,27 .…”

Section: Discussionmentioning

confidence: 99%

Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men

Hang

Strong

et al. 2020

Sci Rep

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Human papillomavirus (HpV) infection contributes to most anal cancers and premalignant intraepithelial lesions. this study investigated anal HpV infections and cytological abnormalities among men who have sex with men (MSM). Sociodemographic characteristics and sexual behaviorswere collected by using a structured questionnaire. Anal cytological results were examined, and HPV genotyping was performed by the Linear Array HPV Genotyping test. Logistic regression was used to estimate risk factors and their associations with high-risk HpV infection and cytological abnormalities. Among 163 MSM, 101 were seropositive for human immunodeficiency virus (HIV) and 62 were seronegative for HIV. The overall prevalence of HPV was 66.2%. A total of 61.9% and 48.2% of participants had never acquired any of either the quadrivalent or nonavalent vaccine HPV types, respectively. Cytological findings showed 15.3% atypical squamous cells of undetermined significance, 16.6% low-grade squamous intraepithelial lesion, 4.9% atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion and 17% high-grade squamous intraepithelial lesion. The number of high-risk HPV types was the predominant risk factor for abnormal anal cytology (OR 2.02, 95% CI 1.27-3.24). Infection with high-risk HPV was a significant predictor for cytological abnormality. MSM should be encouraged to obtain the HpV vaccine.Human papillomavirus (HPV) is an important cause of sexually transmitted diseases worldwide and is associated with malignant transformations in the squamous epithelium of the anus 1 . A rising trend in the incidence of anal cancer has been shown in recent years, increasing from 0.8 per 100,000 person-years in 1975 to 1.8 per 100,000 person-years in 2014 in the United States 2 . The development of anal cancer or pre-cancerous lesions is associated with one's lifetime number of sexual partners, human immunodeficiency virus (HIV) infection, receptive anal intercourse and anal HPV infection, particularly infection with HPV16 3-5 . Moreover, among individuals with anal cancer, nearly 90% of cases are attributable to HPV infection 6 . A recent meta-analysis also showed that the increased prevalence of HPV is associated with the severity of abnormal anal cytology 7 .The incidence of anal cancer among patients with HIV infection is much higher than among the general population (51.4 versus 1.2 per 100,000 person-years) 8 . HIV infection may attenuate the host's immune competence, which then worsens the control of anal HPV infections 9-11 . In addition, HIV seropositives have a decreased probability of clearing anal HPV infection and have prolonged anal HPV infections, compared to HIV seronegatives 11 . The persistent anal HPV infections have been particularly found in high-risk HPV types, which are the predominant risk factors for anal cancer 12,13 . Thus, HIV infection is considered one of the most important independent risk factors for high-risk anal HPV infection [14][15][16][17] .first amplified using polymerase chain reaction. Then...

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Prevalence and Risk Factors for Anal Human Papillomavirus Infection in Human Immunodeficiency Virus–Positive Men Who Have Sex with Men

Abstract: Human papillomavirus 16 is ubiquitously frequent among human immunodeficiency virus -positive men having sex with men, and more strongly associated with high-grade anal lesions than other high-risk types, confirming it as a target for anal cancer prevention.

Cited by 35 publications

References 27 publications

Anal cytological lesions and HPV infection in individuals at increased risk for anal cancer

Anal cytological lesions and HPV infection in individuals at increased risk for anal cancer

Evaluation of anal carcinoma screening in male and female HIV patients at an interdisciplinary HIV therapy centre

Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men

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