Prevalence and risk factors for severity of diabetic neuropathy in type 2 diabetes mellitus

Sharma, Tarun; Raman, Rajiv; Pal, S K; Rani, PadmajaKumari; Rachapalli, SudhirR; Kulothungan, Vaitheeswaran

doi:10.4103/0019-5359.94400

Cited by 35 publications

(19 citation statements)

References 14 publications

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“…have also reported 13% in established cases of retinopathy having neuropathy. [2223] Explanation for a lower rate of diabetic neuropathy among Indians may be due to better skin micro-vascularization compared to Europeans despite having similar risk factors. [24]…”

Section: Discussionmentioning

confidence: 99%

Chronic complications in newly diagnosed patients with Type 2 diabetes mellitus in India

Sosale

Kumar

Sadikot

et al. 2014

Indian J Endocr Metab

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Background:Prevalence of diabetes is on an increase in India, currently there is limited nation-wide data regarding the prevalence of chronic complications in diabetic patients at diagnosis. This information will help health-care professionals approach management more aggressively to prevent complications.Objective:To determine the prevalence of chronic complications in newly-diagnosed Type 2 diabetic (T2D) patients in India.Design and Methods:This was a cross-sectional survey of T2D patients, diagnosed within 3 months of their first visit to the centers doing the survey. Each patient was screened for diabetic complications, hypertension, dyslipidemia, and body mass index. Family history was recorded. Standard protocols were used to make the diagnosis of retinopathy, neuropathy and nephropathy. Data analysis was carried out using the standard statistical techniques.Results:Of the total 4,600 (males 67%, females 33%) newly diagnosed patients with T2D, majority were from the age group 41-50 years (40%). 13.15% of newly detected India T2D had neuropathy 6.1% had retinopathy and 1.06% had nephropathy. Risk factors of macro vascular complication such as hypertension, obesity, and dyslipidemia were observed in 23.3%, 26%, and 27% of patients respectively. Ischemic heart disease was noticed in 6%.Conclusion:High prevalence of micro vascular complications was present at diagnosis along with association of CV cardiovascular risk factors among Indian T2D. In view of this, screening must be instituted for all diabetics for complications at the time of diagnosis itself.

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Section: Discussionmentioning

confidence: 99%

Chronic complications in newly diagnosed patients with Type 2 diabetes mellitus in India

Sosale

Kumar

Sadikot

et al. 2014

Indian J Endocr Metab

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“…DPN is characterized by a marked decrease of lower limbs sensation which causes delays in both proximal and distal peripheral sensory and motor neuron functions [3], consequently leading to musculoskeletal complications that are associated with biomechanical changes of movement [4] and deteriorations of gait performance [5]. In fact, these issues lead to high falls risk [6, 7].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Diabetic Peripheral Neuropathy on Ground Reaction Forces during Straight Walking in Stroke Survivors

Mustapa

Justine

Mustafah

et al. 2017

Rehabilitation Research and Practice

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Purpose. The aim of this present study was to investigate the ground reaction forces (GRFs) alterations in stroke survivors with diabetic peripheral neuropathy (DPN). Methods. Ten stroke survivors with DPN, 10 stroke survivors without DPN, and 10 healthy controls with matched body weight between groups participated in this case-control cross-sectional study. Three-dimensional GRFs (anterior-posterior, medial-lateral, and vertical) were collected at a comfortable walking speed using the Nexus Vicon motion analysis system and force plate. The Kruskal–Wallis test was used to analyze GRFs parameters. Results. We found significant alterations of medial-lateral forces of the nonparetic side and vertical forces of the paretic side in stroke survivors with DPN compared to stroke survivors without DPN and healthy controls. In addition, there were smaller braking and lower propulsion peak in anterior-posterior forces, smaller magnitude of medial-lateral forces, and lower first and second peak of vertical forces in stroke survivors with DPN compared to stroke survivors without DPN and healthy controls. Conclusion. The study findings identified that GRFs were affected in stroke survivors with DPN on both the paretic and the nonparetic sides. Further investigations are warranted to explore the impact of DPN on the kinematics and muscle activity related to the gait performance in stroke survivors with DPN.

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“…(19.5%) and Rani et al (14.4%), respectively. 13,30 The lower prevalence in the present study could possibly be because of a different study setup (tertiary care vs community based), increased knowledge and awareness of diabetes and its complications in recent times leading to earlier type 2 diabetes mellitus diagnosis and control of its complications. The present study was in line with that of Raman et al, which was carried out in a similar clinical set-up including 248 NDDM patients reporting neuropathy prevalence to be 10.5%.…”

Section: Neuropathymentioning

confidence: 79%

“…The estimates of neuropathy prevalence vary widely from 9.6 to 78% in different populations. 13,30,31 This could be attributed to different types of diabetes (e.g. type 1 and type 2 diabetes), genetic predisposition, age of onset of diabetes, existing healthcare facilities, sample selection, different diagnostic criteria used (pin-prick perception, clinical signs and symptoms, and quantitative sensory tests or electrodiagnostic tests).…”

Section: Neuropathymentioning

confidence: 99%

Clinical profile of diabetes in young adults aged 15 to 30 years

Jimnaz¹,

Nishad²,

Harris³

2019

Int J Adv Med

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Background: There is a shift in age of onset of diabetes to a younger age in the recent years. There are very few data available on diabetes in the youth. Hence the study has been undertaken. Objective of the study is to describe the clinical profile of young diabetics and to estimate burden of selected end organ complications at the time of study.Methods: A hospital based Cross sectional study was conducted at a tertiary care centre among 75 young diabetic patients (aged 15-30 years). After taking informed consent, detailed history clinical examination, biochemical investigations like FBS and 2 hours PPBS, HbA1c, lipid profile, screening for neuropathy, retinopathy and nephropathy were done.Results: The mean age of the study population was 26.35±3.8 years, majority were males (62.7 %), 77.3% have positive family history. Mean BMI was 24.8±4.6 kg/m2, 45.3% were overweight ,20 % were obese. The mean FBS levels was 216.63±73.46 mg/dl, 2 hr PPBS 261.51±80.0 mg/dl and mean HbA1c 8.66±1.34 %. The total cholesterol level was higher in 46.7%, with mean of 198.4±21.0. Mean triglyceride level was 136.99±38.9. Nephropathy was present in 25.3%, retinopathy in 13.3% and neuropathy in 9.3 % of the patients. 30.6% had at least one of the three complications. SBP was associated with neuropathy(p=0.030), DBP with retinopathy(p=0.029) and neuropathy(p=0.007) and high FBS levels with retinopathy(p<0.001) and neuropathy(p<0.001).Conclusion: Microvascular complications in young diabetes is alarmingly high. Regular screening, early detection, adequate control of FBS and BP may improve quality of life.

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Prevalence and risk factors for severity of diabetic neuropathy in type 2 diabetes mellitus

Abstract: The results suggested that every fifth individual in a population of type 2 diabetes is likely to have diabetic neuropathy. Nearly 13% had neuropathy of moderate and severe category, making this group vulnerable for complications such as foot ulceration or lower limb amputation.

Cited by 35 publications

References 14 publications

Chronic complications in newly diagnosed patients with Type 2 diabetes mellitus in India

Chronic complications in newly diagnosed patients with Type 2 diabetes mellitus in India

The Effect of Diabetic Peripheral Neuropathy on Ground Reaction Forces during Straight Walking in Stroke Survivors

Clinical profile of diabetes in young adults aged 15 to 30 years

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