Prevalence and risk factors associated with peripheral arterial disease in an adult population from Colombia

Abstract

Background: Cardiovascular diseases (CVD) are the most important cause of mortality in Latin America, while peripheral arterial disease (PAD) is the third leading cause of atherosclerotic cardiovascular morbidity. Objective: To establish the prevalence of PA D and the distribution of traditional CVD risk factors in a population from the Department of Cauca, Colombia. Methods: A cross-sectional study was conducted on a total of 10,000 subjects aged ≥40 years, from 36 municipalities. An ankle---brachial index (ABI) ≤ 0.9 in either leg was used as diagnostic criterion of PAD. Results: Overall PA D prevalence was 4.4% (4.7% females vs. 4.0% males), with diabetes being the most prevalent risk factor (23%). Among individuals self-reporting a history of acute myocardial infarction or stroke, PA D prevalence was 31.0% and 8.1%, respectively. After adjusting for potential confounders, PA D was significantly associated with hypertension (OR 4.6; 95% CI; 3.42---6.20), diabetes (4.3; 3.17---5.75), dyslipidaemia (3.1; 2.50---3.88), obesity (1.8; 1.37---2.30), and cigarette smoking (1.6; 1.26---1.94). Analysis for the interaction of risk factors showed that diabetes, dyslipidaemia, and obesity accounted for 13.2 times the risk for PA D (6.9---25.4), and when adding hypertension to the model, the risk effect was the highest (17.2; 8.4---35.1). Conclusions: Hypertension, diabetes, dyslipidaemia, and obesity, but not smoking were strong predictors of PAD. ABI measurement should be routinely performed as a screening test in

Alt Ekstremite İskemisi Nedeniyle Endovasküler Girişim Planlanan Hastaların Klinik Sonuçları ve Koroner Arter Hastalığı Açısından Değerlendirilmesi

“…24,25 Urbano et al have reported that PAD risk is elevated by 4.7 folds when the TG / HDL ratio is above 4. 23 Consistent with these results, in our study, we found that 68.4% of the PAD patients had DL, and the TG / HDL ratio was 4.53±3.64.…”

“…15 In some studies, the prevalence of PAD was similar in men and women. 22,23 In our study, this rate was higher in male population, and the exact reason of this is currently unknown.…”

“…HT, DM and DL were found to be strong predictors of PAD. 23 Sur et al have found that the prevalence of HT increased with age, and this increase is associated with increased DM, DL, and high CV mortality rates. 26 HT causes an increase in arterial wall thickness and disrupts vascular endothelial function, thus leading to atherosclerosis.27 DL and DM play atherogenic roles in vascular endothelium.…”

“…Elevated total cholesterol, LDL and TG in addition to reduced HDL values are independent risk factors for PAH. 23 It has been shown that increased TG / HDL ratio is a strong independent predictor of CAD. 24,25 Urbano et al have reported that PAD risk is elevated by 4.7 folds when the TG / HDL ratio is above 4.…”

Relación entre los factores de riesgo cardiovascular y el patrón de aterosclerosis de miembros inferiores en pacientes sometidos a angioplastia

“…La causa común es la aterosclerosis 2 . La EAP, después del infarto agudo de miocardio y el accidente cerebrovascular, es la tercera causa principal de morbilidad y mortalidad cardiovascular aterosclerótica en todo el mundo 3 . En 2010, los cálculos sugirieron que > 200 millones de personas en todo el mundo vivían con EAP.…”