Prevalence and prognostic impact of left ventricular non-compaction in patients with thalassemia

Excessive Trabeculation of the Left Ventricle

“…Excessive trabeculation has been described in up to one-sixth of patients with β-thalassemia, raising the issue of a differential diagnosis between cardiomyopathy with excessive trabeculation and thalassemic cardiomyopathy. 88 , 89 , 90 , 91 Echocardiographic data of patients with sickle cell disease and Black control subjects who are healthy and asymptomatic revealed a higher prevalence of excessive trabeculation when compared to patients who are normotensive. 92 …”

High Prevalence of Left Ventricular Non-Compaction and Its Effect on Chemotherapy-Related Cardiac Dysfunction in Patients With Hematological Diseases

“…7-10 Previous studies have reported that LVNC is a genetic disorder with a sporadic and familial form, and several gene mutations linked to LVNC have been found. [11][12][13] The reported prevalence of LVNC varies widely, from 0.26-1.3% in the general population 7,8 to 3.0-3.7% in patients with heart failure, 7,14 7.9-13.3% in patients with β-thalassemia, 15,16 and 19% in patients with dystrophin-associated muscular dystrophy. 17 In recent years, the rate of LVNC detection has increased due to improvements in echocardiographic imaging and magnetic resonance imaging (MRI).…”

“…LVNC prevalence is known to be high in one hematological disease, β-thalassemia. Using cardiac MRI, Piga et al 15 and Bonamini et al 16 reported a prevalence of LVNC of 8-13% in patients with β-thalassemia. Although the present study included patients with various hematological malignancies, almost the same prevalence of LVNC (12%) was found using another imaging modality (echocardiography).…”