High Prevalence of Left Ventricular Non-Compaction and Its Effect on Chemotherapy-Related Cardiac Dysfunction in Patients With Hematological Diseases

Hirano, Mari; Kimura, Kôichi; Ishigaki, Tomohiro; Nojima, Masanori; Daimon, Masao; Morita, Hiroyuki; Takenaka, Katsu; Xu, Boqing; Sawada, Naruhiko; Hirokawa, Megumi; Komuro, Issei; Morisaki, Takayuki; Yotsuyanagi, Hiroshi; Kawamata, Toyotaka; Yokoyama, Kazuaki; Konuma, Takaaki; Kato, Seiko; Nagamura‐Inoue, Tokiko; Uchimaru, Kaoru; Takahashi, Satoshi; Imai, Yumiko; Tojo, Arinobu

doi:10.1253/circj.cj-20-0344

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Determinants and Associations Of Excessive Trabeculation1

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2023

2024

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“…Chemotherapy-related cardiac dysfunction is now also emerging as being potentially associated with excessive trabeculation. 93 , 94 The phenotype has been interpreted as a myocardial response to drug toxicity, but it may also be a consequence, rather than the cause, of the cardiac dysfunction.…”

Section: Determinants and Associations Of Excessive Trabeculationmentioning

confidence: 99%

Excessive Trabeculation of the Left Ventricle

Petersen¹,

Jensen²,

Aung³

et al. 2023

JACC: Cardiovascular Imaging

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Section: Determinants and Associations Of Excessive Trabeculationmentioning

confidence: 99%

Excessive Trabeculation of the Left Ventricle

Petersen¹,

Jensen²,

Aung³

et al. 2023

JACC: Cardiovascular Imaging

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Left Ventricular Non-Compaction in Children: Aetiology and Diagnostic Criteria

Monda,

De Michele,

Diana

et al. 2024

Diagnostics

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Left ventricular non-compaction (LVNC) is a heterogeneous myocardial disorder characterized by prominent trabeculae protruding into the left ventricular lumen and deep intertrabecular recesses. LVNC can manifest in isolation or alongside other heart muscle diseases. Its occurrence among children is rising due to advancements in imaging techniques. The origins of LVNC are diverse, involving both genetic and acquired forms. The clinical manifestation varies greatly, with some cases presenting no symptoms, while others typically manifesting with heart failure, systemic embolism, and arrhythmias. Diagnosis mainly relies on assessing heart structure using imaging tools like echocardiography and cardiac magnetic resonance. However, the absence of a universally agreed-upon standard and limitations in diagnostic criteria have led to ongoing debates in the scientific community regarding the most reliable methods. Further research is crucial to enhance the diagnosis of LVNC, particularly in early life stages.

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