Prevalence and predictors of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods: The Generation R Study

Abstract

of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods: the Generation R Study, Journal of Steroid Biochemistry and Molecular Biology http://dx.doi.org/10. 1016/j.jsbmb.2015.09.018 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ResultsThe prevalence of vitamin D deficiency at midgestation was 26%, while in neonates 46% were deficient. 21% of the mother-infant pairs had persistent vitamin D deficiency (i.e. deficient in maternal and cord samples) and an additional 29% were vitamin D deficient in one of the two samples only. Persistent vitamin D deficiency was strongly associated with non-European ancestry and spring birth. Conclusions

Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies

“…This is in accordance with the results of the studies comparing 25(OH)D 3 levels in pregnant women and in cord blood [5,28]. The Norwegian study reported a 25(OH)D maternal mean level of 41 nmol/l vs cord blood mean level of 31 nmol/l [28] and the Dutch study reported a 25(OH)D maternal mean level of 51 nmol/l vs cord blood mean level of 32 nmol/l [5]. Further, we assayed levels in DBS, while the Norwegian [10] and Finnish [9] studies assayed levels in serum.…”

“…The vitamin D receptor is found in most human cells including cells of the immune system and beta cells [4]. Inadequate vitamin D status is common among pregnant women and neonates [5], and in the latter may influence disease susceptibility in childhood and adolescence. Studies in mice have shown that gestational vitamin D insufficiency and deficiency increase the penetrance of type 1 diabetes [6].…”

Minimizing Matrix Effects for the Accurate Quantification of 25-Hydroxyvitamin D Metabolites in Dried Blood Spots by LC-MS/MS

“…We have also shown that low neonatal concentrations of vitamin D in DBS are associated with an increased risk of schizophrenia and autism in later life (10,11 ). The assay has also been used for assessment of 25OHD concentrations in DBS from 7500 adults, some of whom went on to develop cancer (12 ); to assess the effects of vitamin D supplementation on cognition (13 ); and most recently in 12000 samples from a Dutch cross-sectional cohort (14 ). Ongoing studies are using the assay to assess the relationship between low concentrations of 25OHD in neonatal DBS and juvenile diabetes, eczema, and psychiatric outcomes in twins.…”

Assessment of vitamin D level in the umbilical cord blood of the Arkhangelsk city infants born in winter time

“…Это соотносится с результатами исследований, проведенных в разных странах [15][16][17] и в Российской Федерации [18][19][20] и связано с недо-статочными мерами профилактики дефицита вита-мина D у беременных женщин. Продемонстрировано значительное влияние обеспеченности витамином D матери на показатели 25(ОН)D у новорожденно-го, отмеченное ранее другими исследователями, что еще раз указывает на важнейшую роль уровня 25(ОН)D в крови у матери (являющейся единствен-ным для плода источником этого витамина) в фор-мировании обеспеченности витамином D ребенка.…”