Assessment of vitamin D level in the umbilical cord blood of the Arkhangelsk city infants born in winter time

Малявская, С. И.; Карамян, В Г; Kostrova, G. N.; Lebedev, A.V.

doi:10.21508/1027-4065-2018-63-1-46-50

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Медианы значений витамина D в крови у младенцев на первой неделе жизни не достигают 15 нг/мл, а у большинства (85% новорожденных) уровень метаболита витамина D ниже 20 нг/мл и даже 10 нг/мл. Чаще выраженная недостаточность витамина D выявляется у глубоко недоношенных детей в зимнее время года по сравнению с летним периодом (8,1 [3,3-14,5] нг/мл против 17,9 [4,3] нг/мл, p<0,05) [39]. Однако даже на юге РФ уровень 25(ОН)D 3 в сыворотке крови новорожденных составляет 9,9±0,7 нг/мл (у доношенных новорожденных -9,2±0,8 нг/мл, у недоношенных -10,7±1,1 нг/мл) [40].…”

Section: влияние витамина D на плод и раннее развитие ребенкаunclassified

Effect of vitamin D on the pregnancy and the health of newborns and infants: state-of-the-art

Захарова¹,

Мальцев²,

Зубков³

et al. 2020

Russian Journal of Woman and Child Health

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This paper reviews the effects of vitamin D deficiency on pregnant women and newborns. It was demonstrated that vitamin D deficiency in pregnant women is associated with higher risks of threatened preterm labor, placental insufficiency, preeclampsia, gestational diabetes, bacterial vaginosis, and impaired uterine contractility as well as higher rate of C-sections. Vitamin D insufficiency in newborns is associated with inadequate bone mineralization and also results in metabolic disorders, hypocalcemic seizures, bronchopulmonary dysplasia, necrotic enterocolitis, sepsis, mental and developmental disorders, and higher risks of various (infectious, allergic etc.) disorders. Optimal vitamin D dosing regimen in pregnant women and newborns is discussed.KEYWORDS: pregnancy, vitamin D, vitamin D insufficiency, newborn, complications of pregnancy, preeclampsia, gestational diabetes.FOR CITATION: Zakharova I.N., Mal’tsev S.V., Zubkov V.V. et al. Effect of vitamin D on the pregnancy and the health of newborns and infants: state-of-the-art. Russian Journal of Woman and Child Health. 2020;3(3):174–181. DOI: 10.32364/2618-8430-2020-3-3-174-181.

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Section: влияние витамина D на плод и раннее развитие ребенкаunclassified

Effect of vitamin D on the pregnancy and the health of newborns and infants: state-of-the-art

Захарова¹,

Мальцев²,

Зубков³

et al. 2020

Russian Journal of Woman and Child Health

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Features of respiratory disorders and vitamin D status in preterm infants with a gestational age of more than 32 weeks

et al. 2022

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Background. Preterm infants are at high risk for respiratory distress and vitamin D deficiency, which may be associated with a need for intensive care and long-term respiratory support. Aim. To study the features of respiratory disorders and vitamin D status in preterm infants with a gestational age of more than 32 weeks. Materials and methods. The object of the study were 64 moderate and late preterm infants with respiratory disorders and their mothers. The level of 25(OH)D in cord blood serum was determined by enzyme immunoassay. Results. 60.9% of children were diagnosed with respiratory distress syndrome (Group 1), 39.1% had congenital pneumonia (Group 2). Mothers of all children had a high incidence of chronic diseases and pregnancy complications. Hypovitaminosis D was detected in 71.888% of newborns of both groups, mainly at the stage of deficiency. The median concentrations of 25(OH)D in cord blood serum were 15.41 [12.4934.25] ng/ml in the 1st group of newborns, and 18.42 [14.0123.44] ng/mL in the 2nd group. The need for exogenous surfactant administration and CPAP respiratory therapy is significantly higher in neonates with respiratory distress syndrome. Children with congenital pneumonia significantly more often required mechanical ventilation, and they also had a longer total duration of respiratory support in the form of humidified oxygen supplementation. The duration of inpatient treatment in children of both groups with hypovitaminosis D was significantly higher compared to newborns with adequate levels of vitamin D. Conclusion. Moderate and late preterm infants with respiratory problems should be identified at high risk for hypovitaminosis D, screened for blood levels of 25(OH)D, and developed optimal vitamin D supplementation regimens a promising direction to reduce the risk of preterm birth, neonatal morbidity and reduce the time of inpatient treatment of respiratory disorders.

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Assessment of vitamin D level in the umbilical cord blood of the Arkhangelsk city infants born in winter time

Cited by 2 publications

References 10 publications

Effect of vitamin D on the pregnancy and the health of newborns and infants: state-of-the-art

Effect of vitamin D on the pregnancy and the health of newborns and infants: state-of-the-art

Features of respiratory disorders and vitamin D status in preterm infants with a gestational age of more than 32 weeks

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