Prevalence and predictors of mortality in gastroschisis: a population-based study of 4803 cases in the USA

Brebner, Alison; Czuzoj‐Shulman, Nicholas; Abenhaim, Haim A.

doi:10.1080/14767058.2018.1529163

Cited by 21 publications

(34 citation statements)

References 31 publications

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“…Several studies have reported worldwide increase in the prevalence of gastroschisis from the 1980s and according to recent reports the increasing trend has continued. 2,8,18,28 Similarly in our cohort, there was a marked increasing trend in the live birth prevalence. Additionally, a previous population-based study in Finland showed a significant increase in birth prevalence of gastroschisis from 0.77 to 1.42 per 10,000 during the 1970s.…”

Section: Discussionsupporting

confidence: 70%

“…37 Infant mortality of gastroschisis was 7.7%, in keeping with previous reports. [16][17][18][20][21][22] However, recent reports from the United States have shown mortality rates <5% with no statistical difference between simple and complex cases. 2,7 In our series, mortality was substantially higher for complex gastroschisis (15 vs. 7.2%).…”

Section: Discussionmentioning

confidence: 99%

“…Our data were concordant with previous studies confirming that in most cases gastroschisis is an isolated anomaly. 2,15,18 High rates of prenatal detection of gastroschisis allow planning and selecting the optimal mode of delivery. Both in our series and in other reports, most of these infants are born with caesarean section.…”

Section: Discussionmentioning

confidence: 99%

“…Both in our series and in other reports, most of these infants are born with caesarean section. 18,19 However, recent studies have shown no evidence of the benefits of caesarean section on clinical outcomes such as mortality, sepsis, primary repair, Fig. 2 Increasing, yet not statistically significant, trend of total birth prevalence of gastroschisis.…”

Section: Discussionmentioning

confidence: 99%

“…16,17 Although the majority are born through caesarean section, evidence does not associate the mode of delivery with mortality. 18,19 Once born, these infants require surgical intervention shortly after birth. When appropriate obstetric and neonatal care are provided, the overall survival rates are above 90%.…”

Section: Introductionmentioning

confidence: 99%

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Gastroschisis in Finland 1993 to 2014—Increasing Prevalence, High Rates of Abortion, and Survival: A Population-Based Study

et al. 2019

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Introduction The study aims to assess the changes in prevalence and mortality of gastroschisis, and to identify associated anomalies. Materials and Methods It is a population-based nationwide study. All gastroschisis cases were identified in the Finnish Register of Congenital Malformations and the Care Register for Health Care from 1993 to 2014 including live births, stillbirths, and terminations of pregnancy due to fetal anomalies. Associated anomalies were recorded, and analyzed, and prevalence and infant mortality were calculated. Results There were 320 cases of gastroschisis; 235 (73%) live births, 16 (5%) stillbirths, and 69 (22%) terminations of pregnancy. Live birth prevalence of gastroschisis in Finland was lower than generally reported (1.73 in 10,000). However, due to relatively high rates of abortion, our total prevalence of 2.57/10,000 was similar with other reports. The most common risk factor was young maternal age. Babies with gastroschisis were born prematurely, on average on the 36th week and most are delivered by caesarean section. There was a significant increasing trend in live birth prevalence (p = 0.0018). Overall infant mortality was 7.7% (18/235), 7.2% (16/222) in simple gastroschisis and 15% (2/13) in complex gastroschisis. Associated anomalies were rare both in aborted fetuses and neonates, and there was only one case with a chromosomal abnormality. Conclusion Gastroschisis is usually an isolated anomaly with increasing birth prevalence and excellent survival rates. Regardless of the good prognosis, the abortion rates in Finland are higher than previously reported, and we hypothesize this to be due to lack of appropriate antenatal counselling.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gastroschisis in Finland 1993 to 2014—Increasing Prevalence, High Rates of Abortion, and Survival: A Population-Based Study

et al. 2019

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Trends in prevalence and spatiotemporal distribution of gastroschisis in Arkansas, 1998–2015

ElHassan

Young

Gokun

et al. 2020

Birth Defects Research

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Background: Arkansas (AR) had the highest prevalence of gastroschisis in a recent study including 15 U.S. states. Our objective was to evaluate trends in prevalence and the spatiotemporal distribution of gastroschisis in AR. Methods: Infants with gastroschisis, born 1998-2015, were identified from the Arkansas Reproductive Health Monitoring System. Birth record data were used as denominators for calculations. Maternal residence at delivery was geocoded for spatial analyses. Annual prevalence rates (PRs) were calculated. Joinpoint regression analysis was performed to examine trends in gastroschisis and report the annual percent changes (APCs) in PRs. Spatiotemporal analyses identified counties with unusually high PRs of gastroschisis. Poisson regression, including county, year, and county*year indicators, was fit to evaluate the PRs of gastroschisis, while adjusting for county-level maternal variables. Results: We identified 401 cases of gastroschisis among 694,459 live births. The overall PR of gastroschisis was 5.8/10,000 live births. The prevalence of gastroschisis had a significant APC of +5.3% (p < .0001) between 1998 and 2012, followed by a nonsignificant yearly average decrease of −17% through 2015 (p = 0.2). The Emerging Hot Spot Analysis and SaTScan identified an overlapping five-county cluster from 2006 to 2013. Poisson regression model, including county (inside vs. outside cluster), time (before vs. after 2006), and county*time indicators, was fit to evaluate the PRs of gastroschisis.

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Trends in prevalence of gastroschisis in Brazil from 2007 to 2020: A national population‐based cross‐sectional study

Regadas

Escosteguy

Fonseca

et al. 2023

Birth Defects Research

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Background: Gastroschisis is a congenital abnormality of the abdominal wall which worldwide prevalence is increasing with time. Up to now, young maternal age is the main factor associated with gastroschisis. Brazil has a great proportion of adolescent mothers. Objectives: To estimate prevalence of gastroschisis in Brazil, explore the effect of very young maternal age, and analyze regional distribution and time trends.Methods: Cross-sectional population-based study using data from official national information systems from 2007 to 2020, covering 9,831 gastroschisis cases. Low maternal age was assessed as risk factor through odds ratio. Prevalence time trends by maternal age and geographic area were analyzed using joinpoint regression. Results: Overall prevalence of gastroschisis in Brazil was 2.47 per 10,000 births. From first to last biennium, there was a 23% relative increase. Last biennium prevalence was higher in the Central-west region and lower in the Northeast.Compared to mothers of 20-34 years old (YO), the odds-ratio for prevalence and 95% confidence intervals for gastroschisis were, as follows: (a) 10-14 YO-4.9 (4.3,5.5); (b) 15-19 3.8); and (c) 35-49 YO-0.3 (95% CI 0.3, 0.4). Conclusions: Prevalence of gastroschisis in Brazil relatively increased 23% from 2007 to 2020. This happened in all maternal age groups. Differences between regions may be associated to data quality. Young mothers had a higher prevalence of gastroschisis and still higher for those under 15 YO. Mother age over 34 YO was a protective factor.

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Prevalence and predictors of mortality in gastroschisis: a population-based study of 4803 cases in the USA

Cited by 21 publications

References 31 publications

Gastroschisis in Finland 1993 to 2014—Increasing Prevalence, High Rates of Abortion, and Survival: A Population-Based Study

Gastroschisis in Finland 1993 to 2014—Increasing Prevalence, High Rates of Abortion, and Survival: A Population-Based Study

Trends in prevalence and spatiotemporal distribution of gastroschisis in Arkansas, 1998–2015

Trends in prevalence of gastroschisis in Brazil from 2007 to 2020: A national population‐based cross‐sectional study

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