Prevalence and predictors of metabolic syndrome in drug naïve bipolar patients

Anjum, Shazia; Bathla, Shalu; Panchal, Saminder

doi:10.1016/j.dsx.2018.08.013

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…The study also reported no sex differences in metabolic syndrome among young people, but differences emerged among older people. Another more recent study found an increased prevalence of metabolic syndrome in males than in females with bipolar disorder (41). Depression has also been associated with obesity and metabolic syndrome, with a higher risk in males than in females (42).…”

Section: Sex Differencesmentioning

confidence: 95%

Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness

et al. 2022

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Objective The elevated prevalence of cardiometabolic disorders is consistently reported in patients with severe mental illness (SMI). We explored the association between parental SMI and offspring cardiometabolic morbidity. Our hypothesis was that offspring of people with SMI have increased morbidity risk. Method The Northern Finland Birth Cohort 1966 is a study of offspring whose date of birth was expected in 1966. The follow-up lasted until 2015 (49 years). The final study sample included 11,175 children. We used parental SMI as the exposure in the study. The following cardiometabolic disorders were used as outcome measures: diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, obesity, and cerebrovascular disorders. Results There were 139 (14.7%; hazard ratios [HR] = 1.63; 95% confidence interval [CI] = 1.36–1.94) children of parents with SMI who developed cardiometabolic disorder during follow-up and 957 (9.4%) in the comparison cohort. Statistically significant HRs were found in males (HR = 1.95; 95% CI =1.56–2.44), but not in females (HR = 1.29; 95% CI = 0.96–1.73). Conclusions Having a cardiometabolic disorder was associated with male offspring of parents with SMI. Our findings suggest that there is an elevated risk of coronary artery disease, hyperlipidemia, obesity, and hypertension in the male offspring of parents with SMI. Our results suggest that the somatic health of offspring of parents with SMI should also be considered in addition to their mental health in clinical practice.

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Section: Sex Differencesmentioning

confidence: 95%

Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness

et al. 2022

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A comparative study of prevalence and predictors of metabolic syndrome in various psychiatric disorders in state of Haryana: More than 30 years Vs. less than 30 years

Anjum

Bathla

2019

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Occurrence of metabolic syndrome in untreated bipolar disorders: a cross-sectional study

Liu,

Wang,

Zhen

et al. 2023

Acta Neuropsychiatr.

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Objective: This cross-sectional study aimed to observe the occurrence of metabolic syndrome in untreated individuals with bipolar disorders. Methods: A total of 125 untreated individuals with bipolar disorders were collected as the study group, and 201 cases from the health examination center of our hospital were selected as the control group. The participants enrolled were assessed for general demographic data, case characteristics, and metabolic indexes including body mass index (BMI), blood pressure, triglyceride, HDL-C, cholesterol, LDL-C, and fasting plasma glucose. Results: The incidence of metabolic syndrome in the bipolar disorders group was higher compared to the control group (9.6% VS. 8.5%). After calibrating sex and age data, a significant difference between the two groups was observed (P<0.05). Diastolic and systolic blood pressure were higher in the bipolar disorders group compared to the control group (P<0.01). Men with bipolar disorders had a higher risk of developing metabolic syndrome than women (14.5% vs. 5.8%). Bipolar disorders, sex, age, and BMI were identified as independent risk factors for metabolic syndrome. No significant difference was found in terms of metabolic index and incidence of metabolic syndrome between individuals with depressive episodes (n=37) and manic episodes (n=75). Conclusion: Patients with bipolar disorders were found to have a higher risk of developing metabolic syndrome than healthy individuals. Bipolar disorders, male sex, age, and BMI may contribute to an increased risk of developing metabolic syndrome.

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Prevalence and predictors of metabolic syndrome in drug naïve bipolar patients

Cited by 3 publications

References 36 publications

Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness

Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness

A comparative study of prevalence and predictors of metabolic syndrome in various psychiatric disorders in state of Haryana: More than 30 years Vs. less than 30 years

Occurrence of metabolic syndrome in untreated bipolar disorders: a cross-sectional study

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Prevalence and predictors of metabolic syndrome in drug naïve bipolar patients

Cited by 3 publications

References 36 publications

Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness

Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness

A comparative study of prevalence and predictors of metabolic syndrome in various psychiatric disorders in state of Haryana: More than 30 years Vs. less than 30 years

Occurrence of metabolic syndrome in untreated bipolar disorders: a cross-sectional study

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A comparative study of prevalence and predictors of metabolic syndrome in various psychiatric disorders in state of Haryana: More than 30 years Vs. less than 30 years