Prevalence and predictors of lymphogranuloma venereum among men who have sex with men at a Sydney metropolitan sexual health clinic

Templeton, David J; Sharp, Nicola; Gryllis, Sophie; O’Connor, Catherine; Dubedat, Sally

doi:10.1071/sh12143

Cited by 5 publications

(9 citation statements)

References 7 publications

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“…61,63,65 Although LGV has been identified in the pharynx of MSM overseas, 60,66 a single Australian study failed to identify any cases. 63 Urethral LGV was recently identified in over 2% of MSM with anorectal LGV and almost 7% of their contacts at an Amsterdam clinic, 67 with around half of these infections being asymptomatic.…”

Section: Lymphogranuloma Venereummentioning

confidence: 99%

“…This contrasts with other European data, where a large proportion of asymptomatic anorectal chlamydia has been identified as LGV. 59,60 Anorectal LGV has been identified among Australian MSM in both clinic 61,62 and community-based 63,64 settings. In common with most overseas reports, Australian cases predominantly affect HIV-positive MSM, with symptoms of proctitis.…”

Section: Lymphogranuloma Venereummentioning

confidence: 99%

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Australian sexually transmissible infection and HIV testing guidelines for asymptomatic men who have sex with men 2014: a review of the evidence

et al. 2014

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Abstract.Men who have sex with men (MSM) in Australia and overseas are disproportionately affected by sexually transmissible infections (STIs), including HIV. Many STIs are asymptomatic, so regular testing and management of asymptomatic MSM remains an important component of effective control. We reviewed articles from January 2009-May 2013 to inform the 2014 update of the 2010 Australian testing guidelines for asymptomatic MSM. Key changes include: a recommendation for pharyngeal chlamydia (Chlamydia trachomatis) testing, use of nucleic acid amplification tests alone for gonorrhoea (Neisseria gonorrhoeae) testing (without gonococcal culture), more frequent (up to four times a year) gonorrhoea and chlamydia testing in sexually active HIV-positive MSM, time required since last void for chlamydia first-void urine collection specified at 20 min, urethral meatal swab as an alternative to first-void urine for urethral chlamydia testing, and the use of electronic reminders to increase STI and HIV retesting rates among MSM.

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Section: Lymphogranuloma Venereummentioning

confidence: 99%

Section: Lymphogranuloma Venereummentioning

confidence: 99%

Australian sexually transmissible infection and HIV testing guidelines for asymptomatic men who have sex with men 2014: a review of the evidence

et al. 2014

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“…8 Studies in NSW between 2005 and 2012 identified all cases of LGV in GBM were caused by the L2b serovar. [9][10][11][12] In developed countries, LGV is transmitted primarily through condomless anal intercourse and is commonly associated with HIV, syphilis, gonorrhoea and hepatitis C infections. 1 The use of recreational drugs along with the erectile dysfunction medication sildenafil suggests that certain Australian subgroups of sexually adventurous GBM are at greatest risk of LGV.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of lymphogranuloma venereum in New South Wales, 2006–2015

et al. 2019

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Aim To describe the epidemiology of lymphogranuloma venereum (LGV) in New South Wales (NSW) from 2006 to 2015. Methods LGV notification data between 2006 and 2015 from New South Wales were analysed to describe time trends in counts and rates by gender, age group and area of residence, as well as anatomical sites of infection. A positivity ratio was calculated using the number of LGV notifications per 100 anorectal chlamydia notifications per year. Data linkage was used to ascertain the proportion of LGV cases that were co-infected with HIV. Results There were 208 notifications of LGV in NSW from 2006 to 2015; all were among men, with a median age of 42 years, and half were residents of inner-city Sydney. Annual notifications peaked at 57 (1.6 per 100,000 males) in 2010, declined to 16 (0.4 per 100,000 males) in 2014, and then increased to 34 (0.9 per 100,000 males) in 2015. Just under half (47.4%) of LGV cases were determined to be co-infected with HIV. Conclusion The number of LGV notifications each year has not returned to the low levels seen prior to the peak in 2010. Continued public health surveillance is important for the management and control of LGV.

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“…Condomless receptive anal sex is also associated with an increased risk of anorectal chlamydia [9, 10]. However, anorectal chlamydia is not usually associated with genital ulceration [11, 12]. Syphilis is also associated with condomless receptive anal sex [13].…”

Section: Introductionmentioning

confidence: 99%

Predictors and incidence of sexually transmitted Hepatitis C virus infection in HIV positive men who have sex with men

et al. 2017

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BackgroundSexual transmission of Hepatitis C virus (HCV) in men who have sex with men (MSM) and its interaction with HIV status, sexually transmitted infections and sexual behaviour is poorly understood. We assessed the incidence and predictors of HCV infection in HIV positive MSM.MethodsThe electronic medical record and laboratory results from HIV positive MSM in care at a large urban public specialist HIV clinic embedded in a sexual health centre in Melbourne Australia were collected. Patients with two or more HCV antibody tests between January 2008 and March 2016 and with no record of injecting drug use were included. The HCV exposure intervals were the periods between a negative HCV test and the next HCV test. We compared HCV exposure intervals temporally associated with and without newly acquired syphilis or anorectal chlamydia. HCV exposure intervals were also categorised as being before or after HIV virological suppression and by most recent and nadir CD4 cell count.ResultsThirty seven new HCV infections were diagnosed in 822 HIV positive MSM with no history of injecting drug use over 3114 person years (PY) of follow-up. Mean age was 43.1 years (±12.5) and mean CD4 cell count nadir was 362 cells/uL (±186). The incidence of HCV infection in the study population was 1.19/100PY (0.99–1.38). The incidence in exposure periods temporally close to new syphilis infection was 4.72/100PY (3.35–6.08) and to new anorectal chlamydia infection was 1.37/100PY (0.81–1.93). The incidence in men without supressed viral load was 3.19/100PY (1.89–4.49). In the multivariate Cox regression analysis only younger age (aHR 0.67 (0.48–0.92)), exposure periods temporally associated to new syphilis infection (aHR 4.96 (2.46–9.99)) and higher CD4 cell count nadir (aHR 1.26 per 100 cells/uL (1.01–1.58)) were associated with increased risk of HCV infection. During the study period the incidence of syphilis increased dramatically but the incidence of HCV infection remained the same.ConclusionsIncidence of HCV infection is associated with syphilis but not anorectal chlamydia which suggests a biological rather than behavioural risk modification. Rising syphilis incidence may offset declines in HCV transmission through HCV treatment as prevention.

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Prevalence and predictors of lymphogranuloma venereum among men who have sex with men at a Sydney metropolitan sexual health clinic

Cited by 5 publications

References 7 publications

Australian sexually transmissible infection and HIV testing guidelines for asymptomatic men who have sex with men 2014: a review of the evidence

Australian sexually transmissible infection and HIV testing guidelines for asymptomatic men who have sex with men 2014: a review of the evidence

Epidemiology of lymphogranuloma venereum in New South Wales, 2006–2015

Predictors and incidence of sexually transmitted Hepatitis C virus infection in HIV positive men who have sex with men

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