Prevalence and Phenotypic Distribution of Dyslipidemia in Type 1 Diabetes Mellitus

Pérez, Antonio; Wägner, Ana M.; Carreras, Gemma; Giménez, G.; Sánchez-Quesada, José Luís; Rigla, Mercedes; Gómez-Gerique, J.A.; Pou, J. M.; Leiva, Alberto de

doi:10.1001/archinte.160.18.2756

Cited by 72 publications

(51 citation statements)

References 38 publications

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“…However, the prevalence in the present study was much higher than that found by Polak and cols., who reported that 16% of puberal patients with T1D had elevated TC, while 5% had hypertriglyceridemia (15). Regarding the atherogenic profile, the most commonly reported forms of DLP in patients with T1D include elevated TC, LDL, and TG values (4,6,9) which are similar to the findings observed in the present study.…”

Section: Discussionsupporting

confidence: 90%

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Dyslipidemia in young patients with type 1 diabetes mellitus

Homma

Endo

Saruhashi

et al. 2015

Arch. Endocrinol. Metab.

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Objective: The association between type 1 diabetes mellitus (T1D) and dyslipidemia (DLP) increases the risk of cardiovascular disease (CVD). The aim of this study was to evaluate the presence of dyslipidemia in young T1D patients. Materials and methods: The study design was cross-sectional and descriptive. We reviewed medical records of T1D patients followed at an endocrinology service, from 1998-2012. Data collected: gender, actual age and age at diagnosis, duration of T1D since diagnosis, body mass index (BMI), pubertal stage, glycemic control (GC) determined by glycated hemoglobin (HbA1c), total cholesterol (TC), HDL, LDL, triglycerides (TG). To analyze lipid profile and metabolic control, we used the Brazilian Society of Diabetes Guidelines. Results: Were included 239 T1D patients, 136 (56.9%) females; mean ± SD: actual age 15.7 ± 5.0 years and at T1D diagnosis 7.3 ± 3.9; T1D duration 10.6 ± 6.4 years, 86.6% puberty, 15.1% overweight. The prevalence of DLP was 72.5%, 63.3% females, 86.6% puberty, mean ± SD: actual age 15.4 ± 4.8 years and at T1D diagnosis 7.2 ± 4.1 years, duration of T1D 10.7 ± 6.1 years. We found high-CT in 56.7%, low-HDL = 21.7%, high LDL = 44.0%, high-TG = 11.8%. Between females with DLP, 83.5% was in puberty. We find correlation between the presence of DLP, a poor GC and BMC. Conclusion: We found a high prevalence of DLP in young patients with T1D, particularly in puberty females. Programs targeting the prevention of dyslipidemia should be adopted, especially for this group, in order to prevent/delay chronic complications and cardiovascular disease. Arch Endocrinol Metab. 2015;59(3):215-9

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Section: Discussionsupporting

confidence: 90%

“…However, there are few studies that have investigated the relationship between DLP and T1D in young people; most of the information has been based on adult studies (6,(9)(10)(11). Therefore, this study aimed to determine the prevalence of DLP in young patients with T1D in an endocrinology referral center.…”

Section: Introductionmentioning

confidence: 99%

Dyslipidemia in young patients with type 1 diabetes mellitus

Homma

Endo

Saruhashi

et al. 2015

Arch. Endocrinol. Metab.

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“…However, patients with type 1 diabetes have abnormal HDLs, which are enriched with triglycerides so that in vivo the HDL-decreasing effect of low ABCA1 expression may be counterbalanced by other deregulations of HDL metabolism (42). In addition, low HDL cholesterol is the most frequent dyslipidemia in patients with type 1 diabetes, which becomes manifest especially in patients with insufficient euglycemic control (43). Thus, in patients with type 1 diabetes, HDL cholesterol decreases with increasing blood levels of glycated hemoglobin and increasing albuminuria (44,45), which both are associated with acylemia and ketosis.…”

Section: Discussionmentioning

confidence: 99%

Polyunsaturated Fatty Acids and Acetoacetate Downregulate the Expression of the ATP-Binding Cassette Transporter A1

Uehara

Engel²,

Li³

et al. 2002

Diabetes

115

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“…Quantitative plasma lipid abnormalities characterised by moderate hypertriglyceridaemia and hypercholesterolaemia have been reported in patients with poorly controlled type 1 diabetes [1,2]. Patients with good-to-fair glycaemic control have plasma triglyceride and cholesterol concentrations similar to those observed in healthy subjects; however, qualitative abnormalities have been observed in patients treated with subcutaneous insulin, despite normal plasma lipid levels.…”

Section: Introductionmentioning

confidence: 99%

Normal metabolism of apolipoprotein B100-containing lipoproteins despite qualitative abnormalities in type 1 diabetic men

et al. 2005

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Aims/hypothesis: Type 1 diabetic subjects are at increased risk of cardiovascular disease and exhibit multiple qualitative abnormalities of apolipoprotein (apo) B100-containing lipoproteins. This stable isotope kinetic experiment was designed to study whether these abnormalities are associated with changes in the synthesis and fractional catabolic rates of VLDL-, IDL-and LDLapoB100. Methods: Using a bolus followed by a 16-h constant infusion of 13 C-leucine, we performed a kinetic study in eight men with type 1 diabetes treated with a continuous subcutaneous insulin infusion administered by an external pump and in seven healthy men, in the fed state. Results: The mean HbA 1 c level in the type 1 diabetic patients was 8.00±1.48%. Plasma triglyceride, and total, LDL and HDL cholesterol levels were similar in patients and control subjects. VLDL were less triglyceride rich in type 1 diabetic patients than in control subjects (VLDL triglyceride : apoB 6.91±0.81 vs 8.29±1.24 mmol/ g, p=0.05). Conversely, the IDL and LDL of the type 1 diabetic patients contained relatively higher levels of triglycerides (IDL triglycerides : apoB 2.16±0.36 vs 1.57± 0.30 mmol/g, p<0.01; LDL triglycerides : apoB 0.27±0.06 vs 0.16±0.04 mmol/g, p<0.05). The apoB100 pool size, production and fractional catabolic rates in the two groups of subjects were similar for all lipoprotein fractions. Conclusions/interpretation: Despite qualitative abnormalities, especially abnormalities of triglyceride content, the metabolism of apoB100-containing lipoproteins is not altered in type 1 diabetic men with fair glycaemic control with continuous subcutaneous insulin infusion. The high risk of atherosclerosis in these patients cannot be explained by kinetic abnormalities of apoB100-containing lipoproteins.

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Prevalence and Phenotypic Distribution of Dyslipidemia in Type 1 Diabetes Mellitus

Cited by 72 publications

References 38 publications

Dyslipidemia in young patients with type 1 diabetes mellitus

Dyslipidemia in young patients with type 1 diabetes mellitus

Polyunsaturated Fatty Acids and Acetoacetate Downregulate the Expression of the ATP-Binding Cassette Transporter A1

Normal metabolism of apolipoprotein B100-containing lipoproteins despite qualitative abnormalities in type 1 diabetic men

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