Prevalence and Pathogenesis of Duodenal Ulcer in Chronic Alcoholic Pancreatitis

Jm, Chebli; Af, de Souza; Pd, Gaburri; Kv, Bastos; Tc, Ribeiro; Rj, Filho; La, Chebli; Le, C

doi:10.1097/00004836-200207000-00015

Cited by 12 publications

(7 citation statements)

References 23 publications

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“…In chronic alcoholic pancreatitis, some studies did not demonstrate any difference in the prevalence of H. pylori infection status in patient with DU. 13,24 Our findings were in agreement with those reports that positive H. pylori status either by pathology or serology was not different in AIP or in nonautoimmune CP whether they had DU or not. Moreover, the frequency of positive H. pylori infection status was similar in both patients with AIP and patients with nonautoimmune CP who had GU.…”

Section: Discussionsupporting

confidence: 92%

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Autoimmune Pancreatitis Associated With High Prevalence of Gastric Ulcer Independent of Helicobacter pylori Infection Status

Chang

Chang²,

Wei³

et al. 2009

Pancreas

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Section: Discussionsupporting

confidence: 92%

“…13 Our data were concordant to their findings. The prevalence of DU (30.0% in AIP vs 20.4% in nonautoimmune CP) was higher than GU in both patients with AIP and patients with nonautoimmune CP.…”

Section: Discussionsupporting

confidence: 91%

Autoimmune Pancreatitis Associated With High Prevalence of Gastric Ulcer Independent of Helicobacter pylori Infection Status

Chang

Chang²,

Wei³

et al. 2009

Pancreas

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“…[50]One study found a higher prevalence of left-sided colitis, higher mortality, and higher usage of biological agents in Mexican population than in Mexican-American population, supporting the role of environmental factors on clinical characteristics of IBD. [24] The larger case-series in LAC Countries are from 1946 to date are from Argentina [14,51,52], Barbados [13], Brazil [14,[53][54][55][56][57][58][59][60][61][62][63][64][65], Chile [66][67][68], Cuba [69], Peru [70,71], Puerto Rico [72][73][74][75] and Uruguay. [76][77][78] Most CD localizations were ileal-colonic and CD behavior was mostly inflammatory, followed by penetrant or stenotic.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study

et al. 2020

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Background and aims Ulcerative Colitis (UC) and Crohn's Disease (CD) have a major impact on quality of life and medical costs. The aim of the study was to estimate the prevalence, incidence and clinical phenotypes of Inflammatory Bowel Disease (IBD) cases in Mexico and Colombia. Methods We analyzed official administrative and health databases, used mathematical modelling to estimate the incidence and complete prevalence, and performed a case-series of IBD patients at a referral center both in Mexico and Colombia. Results The age-adjusted complete prevalence of UC per 100,000 inhabitants for 2015/2016 ranged from 15.65 to 71.19 in Mexico and from 27.40 to 69.97 in Colombia depending on the model considered. The prevalence of CD per 100,000 inhabitants in Mexico ranged from 15.45 to 18.08 and from 16.75 to 18.43 in Colombia. In Mexico, the age-adjusted incidence of UC per 100,000 inhabitants per year ranged from 0.90 to 2.30, and from 0.55 to 2.33 in Colombia. The incidence for CD in Mexico ranged from 0.35 to 0.66 whereas in Colombia, the age-adjusted incidence of CD ranged from 0.30 to 0.57. The case-series included 200 IBD patients from Mexico and 204 patients from Colombia.

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“…Their data showed a prevalence of IgG antibodies against H pylori in 60% of patients with chronic pancreatitis complicated by duodenal ulcer, compared to 86% in controls with simple duodenal ulcer. Another study investigated the pathogenesis of duodenal ulcer in chronic alcoholic pancreatitis patients [28] and found a significant increase in the rate of H pylori infection in patients with chronic alcoholic pancreatitis and duodenal ulcer as compared to patients with chronic alcoholic pancreatitis only (87% vs 54%, P = 0.02). These authors suggested that H pylori infection seems to play a significant role in duodenal ulcer disease associated with chronic alcoholic pancreatitis.…”

Section: Figurementioning

confidence: 99%

H pyloriinfection causes chronic pancreatitis in Mongolian gerbils

Rieder¹,

Karnholz

Stoeckelhuber

et al. 2007

WJG

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AIM: To investigate whether chronic H pylori infectionhas the potential to induce pancreatitis in the Mongolian gerbil model, and whether it is dependent on an intact type Ⅳ secretion system. METHODS:Mongolian gerbils were infected with wild type (WT) H pylori typeⅠstrain B128 or its isogenic mutant B128 ∆cagY (defective type Ⅳ secretion). After seven months of infection, H pylori was reisolated from antrum and corpus and H pylori DNA was analyzed by seminested polymerase chain reaction (PCR). Inflammation and histological changes were documented in the gastric antrum, corpus, and pancreas by immunohistochemistry. Cytokine mRNA, gastric pH, plasma gastrin, amylase, lipase, and glucose levels were determined. RESULTS:The H pylori infection rate was 95%.Eight infected animals, but none of the uninfected g r o u p , d e v e l o p e d t r a n s m u r a l i n f l a m m a t i o n a n d chronic pancreatitis. Extensive interstitial fibrosis and inflammation of the pancreatic lobe adjacent to the antrum was confirmed by trichrome stain, and immunohistochemically. Pro-inflammatory cytokine mRNA was significantly increased in the antral mucosa of all infected gerbils. In the corpus, only cytokine levels of WT-infected animals and those developing transmural inflammation and pancreatitis were significantly increased. Levels of lipase, but not glucose or amylase levels, were significantly reduced in the pancreatitis group. H pylori DNA was detected in infected antral and corpus tissue, but not in the pancreas.CONCLUSION: H pylori infection is able to induce chronic pancreatitis in Mongolian gerbils independently of the type Ⅳ secretion system, probably by an indirect mechanism associated with a penetrating ulcer.

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Prevalence and Pathogenesis of Duodenal Ulcer in Chronic Alcoholic Pancreatitis

Abstract: These data demonstrate that the prevalence of DU in CAP is relatively high. H. pylori infection seems to play the major pathogenetic role in DU associated with CAP.

Cited by 12 publications

References 23 publications

Autoimmune Pancreatitis Associated With High Prevalence of Gastric Ulcer Independent of Helicobacter pylori Infection Status

Autoimmune Pancreatitis Associated With High Prevalence of Gastric Ulcer Independent of Helicobacter pylori Infection Status

Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study

H pyloriinfection causes chronic pancreatitis in Mongolian gerbils

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