Prevalence and Natural History of Celiac Disease in a Cohort of At‐risk Children

Abstract

Prevalence of CD in this cohort was 4%, half of whom had digestive symptoms. Because a high proportion of children showed a spontaneous disappearance of antibodies, prevalence studies of CD in young children should be based on intestinal damage so as not to overestimate results.

Frequency of Diagnosed Gastrointestinal & Liver Diseases in Paediatric out Patient Department at a Tertiary Care Hospital of Karachi, Pakistan

“…G.I related diseases include celiac disease which was the most common disease presented to outdoor patient which was found to be 17.8%, where as in an another study it was found to be 7%, which was low In comparison [3] , furthermore there were also underdiagnosed cases of celiac disease, similarly tissue transglutaminase were positive in 61.1% of the patients with celiac disease in our study, whereas Trovato. CM et al in his study reported that paediatric patients with seropositive TTG were 68.5% [13] , patients with the celiac disease develop polyautoimmunity [14] , Unusual high rate of incidence of celiac disease has been reported in study conducted at Sweden, during 40 year time period 1030 patients have celiac disease [15] , another article reported the prevalence of celiac disease which is found to be 4.1% [16] , whereas its frequency among children of Germany is found to be 0.9% [3] .…”

The Effect of Celiac Disease on the Oral Cavity: A Review )

“…The prevalence of Celiac disease is 2%-3% in Finland and Sweden, 0.2% in Germany [15], 1.6% in Asia [16], and 1% in the United States [17]. The prevalence was 4% in a recent study by Cilleruelo et al [9] who used the HLA-DQ2 test [9]. This variability in the worldwide prevalence can be attributed to differences in the type of test used for screening, sample size, age, and criteria for celiac disease diagnosis among studies [18,19].…”

“…Celiac disease is diagnosed on the basis of clinical symptoms; serological tests for the detection of serum immunoglobulin (Ig) A (IgA), TTG antibody, and IgA-endomysial antibody; and histopathological examination of biopsy specimens from the intestinal mucosa [6,7]. Recently, genetic studies identifying HLA DQ2/DQ8 antigens have been utilized more frequently [8], because the spontaneous disappearance of antibodies over time has been observed in a proportion of children with Celiac disease [9]. Approximately 83% patients remain undiagnosed or are misdiagnosed, which can result in irreversible medical and dental complications [10].…”

Prevalence of celiac disease in Saudi children: Is it underestimated?

“…Small intestinal biopsy was offered to those who tested positive for IgA-tTG [IgA-tTG > 20 relative units (RU)/mL]. [ 1 ] Since a proportion of children with CD have been shown to have a spontaneous disappearance of antibodies over time,[ 2 ] I presume that significant percentage of potentially silent CD were missed from Al Hatlani's study. (2) The consumption of wheat containing gluten as a major staple food is still a common custom in the Kingdom of Saudi Arabia (KSA).…”