Prevalence and incidence of anti-SARS-CoV-2 antibodies among healthcare workers in Belgian hospitals before vaccination: a prospective cohort study

Mortgat, Laure; Verdonck, Kristien; Hutse, Veronik; Thomas, Isabelle; Barbezange, Cyril; Heyndríckx, Leo; Fischer, Natalie; Vuylsteke, Béa; Kabouche, Ines; Ariën, Kevin K.; Desombere, Isabelle; Duysburgh, Els

doi:10.1136/bmjopen-2021-050824

Cited by 21 publications

(24 citation statements)

References 25 publications

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“…Their role in the chain of transmission is essential, through which they help in the control and prevention of the spread of COVID-19 infection. For these reasons, vaccination strategies of many countries including Jordan focused on treating HCWs as a priority group [ 14 ]. It was reported that Jordan was among the first 40 countries to be vaccinated, the campaign was launched on 13 January 2021 beginning with healthcare workers, people with chronic diseases, and those over the age of 60 [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected?

et al. 2022

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Background: The effective immunization of healthcare workers (HCWs) plays a vital role in preventing the spread of SARS-CoV-2 infection during the coronavirus disease 2019 (COVID-19) pandemic. There is limited data on the immune response to vaccination among HCWs. We aim to determine seroprevalence rates and neutralizing IgG antibody response to various immunizations among HCWs. Methods: This study was conducted between July and September 2021, in which blood samples were obtained from HCWs and SARS-CoV-2 IgG neutralizing antibodies were measured. Data regarding vaccination status with Pfizer/BioNTech, Sinopharm, or AstraZeneca vaccines, occupation, and prior COVID-19 infection were analyzed. Results: COVID-19 infection post-vaccination was associated with higher mean antibody titers, regardless of vaccine type. Pfizer/BioNTech vaccination produced higher mean antibody titers for HCWs with prior COVID-19 infection (p < 0.00001) than other types of vaccines. Although 96% of HCWs were vaccinated, 3% were seronegative. For HCWs who were seropositive, there were no significant differences between the mean antibody titers when comparing occupations and blood indices. Conclusion: Awareness of the immunity status of HCWs is key to protecting this important group against SARS-CoV-2, especially those without prior COVID-19 infection. Further public health efforts regarding booster vaccination for HCWs are crucial to provide necessary antibody protection.

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Section: Introductionmentioning

confidence: 99%

Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected?

et al. 2022

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“…The majority of those who oppose vaccination (53.2%) believe that "the side effects of vaccination are not yet well enough known or researched". seroprevalence was estimated to be around 20% in the general population [5,6] and up to 42%…”

Section: Vaccination and Testing Strategymentioning

confidence: 99%

Survey on “Knowledge and Attitudes Regarding the Coronavirus Pandemic” in the Austrian, German and Swiss population

Schabus¹,

Eigl²

2021

Preprint

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The survey on “Knowledge and Attitudes Regarding the Coronavirus Pandemic” was available online from 17. Jan 2021 to 19. Feb 2021 for the Austrian population. The aim of the study was to obtain a representative overview of the assessment of the current pandemic situation by the German-speaking general population (Austria, Germany, and Switzerland). Altogether the results of this survey in German-speaking countries (here with a focus on Austria) reflects the high degree of the psychological burden and anxiety regarding SARS-CoV-2 in the general population. The subjectively estimated threat of the disease (hospitalisation or mortality) is vastly overestimated and contributes to the degree of psychosocial burdens in the Austrian population. The aftermath of the pandemic is just beginning and the public focus should finally be turned to those indirectly harmed by the coronavirus measures in order to prevent a meltdown of well-being and general somatic as well as mental health in the general population.

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“…COVID-19 seroprevalence studies have been conducted in several countries; as, among others, in Switzerland [ 8 ], Portugal [ 9 ], Austria [ 10 ], and England [ 11 ]. In Belgium, studies have first been set up in specific population groups such as blood donors [ 12 ], hospital healthcare workers [ 13 ], primary healthcare workers [ 14 ], schoolchildren and school staff [ 15 ], and residents and staff in nursing homes [ 16 ]. The SalivaHIS study is complementary to these studies as it assesses the prevalence of anti-SARS-2-CoV antibodies in the community dwelling population aged 18 years and older.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Anti-SARS-CoV-2 Antibodies and Potential Determinants among the Belgian Adult Population: Baseline Results of a Prospective Cohort Study

Leclercq

Houte

Gisle

et al. 2022

Viruses

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The prevalence of anti-SARS-CoV-2 antibodies and potential determinants were assessed in a random sample representative of the Belgian adult population. In total, 14,201 individuals (≥18 years) were invited by mail to provide saliva via an Oracol® swab. Survey weights were applied, and potential determinants were estimated using multivariable logistic regressions. Between March and August 2021, 2767 individuals participated in the first data collection. During this period, which coincided with the onset of the vaccination campaign, the seroprevalence in the population increased from 25.2% in March/April to 78.1% in July. Among the vaccinated there was an increase from 74,2% to 98.8%; among the unvaccinated, the seroprevalence remained stable (around 17%). Among the vaccinated, factors significantly associated with the presence of antibodies were: having at least one chronic disease (ORa 0.22 (95% CI 0.08–0.62)), having received an mRNA-type vaccine (ORa 5.38 (95% CI 1.72–16.80)), and having received an influenza vaccine in 2020–2021 (ORa 3.79 (95% CI 1.30–11.07)). Among the unvaccinated, having a non-O blood type (ORa 2.00 (95% CI 1.09–3.67)) and having one or more positive COVID-19 tests (ORa 11.04 (95% CI 4.69–26.02)) were significantly associated. This study provides a better understanding of vaccine- and/or natural-induced presence of anti-SARS-CoV-2 antibodies and factors that are associated with this presence.

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Prevalence and incidence of anti-SARS-CoV-2 antibodies among healthcare workers in Belgian hospitals before vaccination: a prospective cohort study

Cited by 21 publications

References 25 publications

Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected?

Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected?

Survey on “Knowledge and Attitudes Regarding the Coronavirus Pandemic” in the Austrian, German and Swiss population

Prevalence of Anti-SARS-CoV-2 Antibodies and Potential Determinants among the Belgian Adult Population: Baseline Results of a Prospective Cohort Study

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