Prevalence and heritability of psoriasis and benign migratory glossitis in one Brazilian population

Abstract

BackgroundAn oral condition associated to psoriasis is benign migratory glossitis. The review of the literature does not show any publication about heritability in both soriasis and benign migratory glossitis and prevalence of psoriasis in the Brazilian population.ObjectiveThis research was carried out in order to determine the prevalence of psoriasis and benign migratory glossitis in the Brazilian population from a Brazilian sample, as well as the heritability in these conditions.MethodsSix thousand patients were studied from the records of the outpatient dermatology department. The sample had 129 patients with cutaneous psoriasis, 399 with benign migratory glossitis without psoriasis and a control group with 5,472 patients. After data collection, the statistical analysis was made using Woolf, Chi-square and Falconer tests.ResultsThe prevalence of psoriasis was 2.15% and the benign migratory glossitis was 7.0%. The prevalence of benign migratory glossitis in the psoriasis group was high (16.3%), and that was statistically significant. Family history in the psoriasis group was 38% for the condition itself and 2,75% for benign migratory glossitis and in the benign migratory glossitis group was 17.54% for the condition itself and 1.5% for psoriasis. The study of heritability was 38.8% for psoriasis and 36.6% for benign migratory glossitis, both with medium heritability.Study limitationsThis study was only in the state of São Paulo.ConclusionThis is the first publication that quantifies how much of these conditions have a genetic background and how important the environmental factors are in triggering them.

Association between geographic tongue and psoriasis: A systematic review and meta‐analyses

“…A total of 1146 irrelevant publications were excluded after screening titles, and 23 articles were considered as potentially relevant. The full texts of these articles were screened and 11 studies finally met the inclusion criteria . Figure details the study selection flow chart.…”

“…The community controls were selected from visitors in a general hospital, companions of the patients, hospital staff, people who attended medical check‐ups and volunteers from bone marrow donors . Other controls were selected among patients from Dentistry schools and Dermatological clinics, diagnosed with pigmented lesions, onychomycosis and other cutaneous diseases . Five studies stated that controls had to have no history of dermatological disease …”

“…A family history of psoriasis was recorded in 17% (34/200) and 25.58% (33/129) of the patients from two studies.…”

“…The results of the quality assessment of the studies, according to the GRADE checklist, are shown in Table . Six studies had a moderate level, and five had a high level of quality …”

“…The presence of GT and the clinical form of psoriasis (plaque‐type vs non‐plaque‐type; erythrodermic vs non‐erythrodermic) were not statistically associated. The sensitivity analysis determined that the funnel plot would be more symmetrical if the studies performed by Germi et al and Jorge et al were excluded. Egger's test corroborated the homogeneity of the included studies.…”