Prevalence and heritability of benign prostatic hyperplasia and LUTS in men aged 40 years or older in Zhengzhou rural areas

Abstract

Background: Benign prostate hyperplasia (BPH) is the most common disease among aging males, but no reports have addressed the prevalence of BPH in Zhengzhou. Therefore, we aimed to understand the prevalence of BPH in men aged 40 years or older in Zhengzhou's rural areas through a cross-sectional study and analyzed the correlation with epidemiologic factors and the heritability of the disease. Materials and Methods:A multistage sampling method was used to randomly select male respondents in Zhengzhou's rural areas. Men who were 40 years of age or older and their first-degree relatives were subjected to the International Prostate Symptom Score (IPSS) and related examinations. Heritability was calculated according to the prevalence of the first-degree relatives in the case and control groups.Results: The prevalence of BPH was 10.04%. Its prevalence increased with age, from 2.17% in men aged 40-44 years to 31.11% in men aged 80 years or older. The average volume of the prostate was 17.16 ± 7.96 mL, and the average IPSS was 5.89 ± 5.91. The analysis of the correlation between the associated risk factors and BPH revealed that prostatitis and a history of prostatic hyperplasia were significant factors. Obesity, smoking, drinking, diabetes, and hypertension were not correlated with BPH. Of the 94 first-degree relatives of the cases, 53 had BPH (56.38%); of the 106 first-degree relatives of the controls, five had BPH (4.72%). Heritability appeared to account for 40.48% of BPH cases.The heritability of incomplete emptying, frequency, intermittency, urgency, weak stream, straining, and nocturia was 43. 28, 71.37, 9.67, 5.67, 2.70, 53.36, and 19.12%, respectively. Conclusion:The total prevalence of BPH in men aged 40 years or older in Zhengzhou's rural areas was 10.04%, and the heritability of prostatic hyperplasia was 40.48%. K E Y W O R D Sbenign prostatic hyperplasia, heritability, LUTS, prevalence, rural

The prevalence and associated factors of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in aging males

“…Age remains one of the key risk factors of LUTS/BPH in aging population of China. Latest research in rural areas of Zhengzhou, Henan Province, China, indicates the overall prevalence of BPH is 10.04% ranging from 2.17% aged 40-44 years to 31.11% aged 80 years above [24]. Our study also indicates participants suffer higher odds of LUTS/BPH in pace with aging.…”

A Preliminary, Multicenter, Prospective and Real World Study on the Hemostasis, Coagulation, and Safety of Hemocoagulase Bothrops Atrox in Patients Undergoing Transurethral Bipolar Plasmakinetic Prostatectomy

“…It is one of the common diseases in middle-aged and elderly men, and causes a huge burden (Saigal and Joyce, 2005; Speakman et al, 2015). An epidemiological survey on BPH in rural areas in Zhengzhou (a city in central China) showed that the prevalence of BPH was 10.04%, and with age increasing this figure increased from 2.17% in individuals aged 40–44 years to 31.11% in those 80years or older (Yue et al, 2019), which were consistent with findings from a meta-analysis (Wang et al, 2015b) and a survey in Europe (Foster et al, 2015). Main clinical symptoms refer to LUTS, including frequent micturition, urinary urgency, urination inability, trouble in urination starting, etc (Martin et al, 2011; Ho et al, 2018).…”

The association between metabolic syndrome and lower urinary tract symptoms suggestive of benign prostatic hyperplasia in aging males: evidence based on propensity score matching

“…According to one recent study, the prevalence of LUTS/ BPH in aging Chinese males is 11.97%, and is 22.70% in participants aged 70 years old and above (3). Yue et al reported that the prevalence of BPH ranges from 2.17% in men aged 40-44 years to 31.11% in men aged 80 years and above (4). In America, this disease affects an estimated 15 million men aged 30 years and older (5).…”