The association between metabolic syndrome and lower urinary tract symptoms suggestive of benign prostatic hyperplasia in aging males: evidence based on propensity score matching

Abstract

Background: To investigate the association between lower urinary tract symptoms suggestive of benign prostate hyperplasia (LUTS/BPH) and metabolic syndrome (MetS) in aging Chinese males. Methods: A dataset that included 3,568 non-MetS cases and 1,020 MetS cases (after data cleansing) was downloaded from the China Health and Retirement Longitudinal Study (CHARLS). To balance the intergroup covariates, propensity score matching (PSM) was employed in the analyses. Univariate logistic regression and multivariate logistic regression were then performed to investigate the relationship between LUTS/BPH and MetS in aging Chinese males. Results: Before PSM, multivariate logistic regression showed that participants with MetS had a 1.47 times higher risk of LUTS/BPH compared to non-MetS cases in the final model (P<0.001). It also revealed that participants with low high-density lipoprotein (HDL), abdominal adiposity, or high triglycerides had a higher probability of LUTS/BPH [odds ratio (OR) =1.56 for low HDL; OR =1.50 for abdominal adiposity;and OR =1.48 for high triglyceride, P<0.001], while participants with hyperglycemia or hypertension had identical odds of LUTS/BPH (P>0.05). After PSM, 1,000 pairs were successfully matched. It was also found that MetS cases had a 1.60 times higher risk of LUTS/BPH compared to non-MetS cases (P<0.001), and participants with low HDL, abdominal adiposity, high triglycerides, or hyperglycemia had a higher likelihood of LUTS/BPH than their counterparts (P<0.001). However, the probability of LUTS/BPH in hypertensive patients remained similar to that in non-hypertensive patients (P>0.05).Conclusions: Aging Chinese males with MetS had a higher probability of LUTS/BPH. Also, patients with low HDL, abdominal obesity, high triglycerides, or hyperglycemia had an increased risk of LUTS/BPH; however, this was not the case for hypertensive patients.

The Circadian Syndrome Predicts Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia Better Than Metabolic Syndrome in Aging Males: A 4-Year Follow-Up Study

“…This association between MetS and LUTS/BPH was in line with previous findings ( 19 – 22 ). Xiong et al found that men with MetS had 1.47 times of LUTS/BPH than the healthy counterparts in Chinese aging men ( 19 ).…”

“…This association between MetS and LUTS/BPH was in line with previous findings ( 19 – 22 ). Xiong et al found that men with MetS had 1.47 times of LUTS/BPH than the healthy counterparts in Chinese aging men ( 19 ). Cosimo et al also disclosed that MetS increased the risk of moderate/severe nocturia in patients with LUTS/BPH ( 22 ).…”

Icariin ameliorates metabolic syndrome-induced benign prostatic hyperplasia in rats

“…These include central obesity, insulin resistance and dyslipidemia (Vignozzi et al 2016). In fact, the link between BPH and MetS in humans is well recognized (Ozden et al 2007;Xiong et al 2021). In the current work, MetS was achieved by keeping rats on high-fructose drinking water and high-salt diet.…”

Relationship Analysis of Inorganic Arsenic Exposure and Metabolic Syndrome Based on Propensity Score Matching in Xinjiang, China

“…When the standardized deviation of each variable is within ± 10%, it indicates that the matching belongs to the high precision. 33 Finally, subgroup analysis was used to ascertain the consistency of the data from various subgroups. SPSS 25.0 was used for univariate analysis and logistic regression analysis.…”