Prevalence and genotype distribution of cervical human papillomavirus (HPV) among women in urban Tianjin, China

Chen, Xiujie; Wallin, Keng-Ling; Duan, Meng; Gharizadeh, Baback; Zheng, Baodong; Qu, Pengpeng

doi:10.1002/jmv.24248

Cited by 31 publications

(52 citation statements)

References 33 publications

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“…A so‐called “Asia exception” showed a downward trend in infection rates after the age range of 46‐50 years. Some previous studies have suggested that the prevalence of HPV infection is highest in women aged 20‐24 years because of sexual activity, which supports our results for women aged ≤25 years. The characteristics of the age‐specific distribution were similar to those seen in the global and Asian HPV infection trends.…”

Section: Discussionsupporting

confidence: 92%

“…Given that China covers a vast territory, the prevalence patterns differ regionally, even among different regions of mainland China. For example, different prevalence rankings of HPVs are seen in Beijing with HPVs 16, 58, 33, and 36 and Tianjin with HPVs 16, 58, 18, and 66 (both are part of Northern China); Shanghai with HPVs 52, 16, 58, 53, and 33 (Eastern China); Zhejiang Province with HPVs 16, 58, 18, and 52 (Southern China); Wuhan with HPV 52, followed by HPVs 16, 58, 39, 51, and 53 (Central China), as seen in this study; Yunnan province with geographically and ethnically diverse distribution characteristics (Western China). In sum, these regional differences may be due to variation in the ranking of the prevalence estimates of these HPV genotypes by region.…”

Section: Discussionsupporting

confidence: 60%

“…The most common HPV genotype associated with multiple or coinfections was HPV 52, followed by HPVs 58 and 16 in HR‐HPVs, and HPV 81 in LR‐HPVs. As the risk of low‐grade squamous intraepithelial lesions (LSIL) was found to increase with the coinfection of HPV 16 and other genotypes, the results here may indicate that multiple HPV infections, especially infections involving HR‐HPVs, should receive more clinical attention. The present study also shows that the total, single, and multiple HPV infection rates (15.60%, 7.10%, and 22.65%, respectively) in the ≤25 age group were the highest among all the age groups, which may be because HPV is a sexually transmitted disease, and there is a relatively high frequency of sexual intercourse and a greater number of sexual partners in younger women .…”

Section: Discussionmentioning

confidence: 79%

“…Previous epidemiological studies have shown that the prevalence of HPV infection and genotype distribution differs among regions, and a molecular epidemiological study of HPVs could provide useful data to support reasonable local vaccination strategies . There is a great need for more local data on HPV infections and genotype distribution in women of different populations, which can then be used to evaluate the efficacy of the HPV vaccine in different populations and contribute to the development of cervical cancer screening . China covers a large territory and has many ethnic groups, and the distribution characteristics of HPVs in different regions are not the same.…”

Section: Introductionmentioning

confidence: 99%

“…18 There is a great need for more local data on HPV infections and genotype distribution in women of different populations, which can then be used to evaluate the efficacy of the HPV vaccine in different populations 19 and contribute to the development of cervical cancer screening. 20 China covers a large territory and has many ethnic groups, and the distribution characteristics of HPVs in different regions are not the same. Wuhan is a city in central China with a 2014 population of 10.34 million, and it is one of the largest cities in China.…”

Section: Introductionmentioning

confidence: 99%

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Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China

Xiang

Guan

Liu

et al. 2018

Clinical Laboratory Analysis

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BackgroundHuman papillomaviruses (HPVs) are strongly associated with the development of cervical carcinoma, and the distribution of HPV genotypes varies regionally.MethodsTo investigate the distribution characteristics of different genotypes of HPV infection in women in Wuhan, China, a total of 13 775 patients were enrolled over 2 years.ResultsOf these, 2436 patients were infected with HPVs, and the total infection rate was 17.68%. The infection rate of high‐risk HPV (HR‐HPV) was significantly higher (13.96%) than that of single low‐risk HPV (LR‐HPV; 3.72%). Among the HR‐HPV infections, the most common genotype was HPV 52 with an infection rate of 4.23%, followed by HPVs 16, 58, 39, and 51. The most common LR‐HPV genotype was HPV 81, followed by HPVs 6, 11, and 44. Patients under the age of 25 years were found to have the highest HPV infection rate (P < .05). After the age range of 51‐55 years, a downward trend in total HPVs and HR‐HPVs was observed. The HPV infection rate for a single genotype was higher than that for multiple HPVs (P < .01), and the detection rates in summer and winter were significantly higher than those in spring and autumn.ConclusionsThe results demonstrate that the distribution characteristics of various HPV genotype infections are associated with region and age and may be related to season. These data could be the basis for further epidemiological analysis into the control and prevention of HPV infection in this region.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China

Xiang

Guan

Liu

et al. 2018

Clinical Laboratory Analysis

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Age‐specific prevalence and genotype distribution of human papillomavirus in women from Northwest China

et al. 2022

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Background: Human papillomavirus (HPV) is the leading cause of cervical cancer with more than 200 genotypes. Different genotypes have different potentials in causing premalignant lesions and cervical cancers. In this study, we investigated the age-specific prevalence and genotype distribution of HPV genotypes in Northwest China. Materials and Methods: We recruited 145,918 unvaccinated women from Northwest China for population-based HPV DNA screening test during June 2015 to December 2020. And a lab-based test was performed for each volunteer by flow fluorescent technology to identify the genotypes of HPV. Results:The overall infection rate of HPV was 22.97%. With the participants divided into 12 groups according to age, a bimodal curve of infection rate was obtained. And the two peaks appeared in the younger than 20 group and 61-65 group, respectively. The five most common HPV genotypes included HPV 16, 58, 52, 53 and 61 in all participants, which were in descending order of frequency.Among women younger than 25 years old, HPV 6 and 11 were more common and even higher than some genotypes mentioned above. Among women older than 65 years old, HPV 18 and 66 were more common than or as high as the six most common genotypes in all populations. Additionally, the distribution of single and multiple infections in each age group was also different. Conclusion:The baseline prevalence and genotype distribution of HPV in Northwest China was uncovered for the first time. Age was related to the epidemiology of different HPV genotypes. All the results would be of great significance for future healthcare services.

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The distribution and prevalence of human papillomavirus in women in mainland China

Song

et al. 2019

Cancer

133

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We conducted a systematic review of the epidemiology of high-risk human papillomavirus (HPV) infections in mainland Chinese women to provide a general profile for the application and subsequent effectiveness evaluation of HPV vaccines. The PubMed, Web of Science, Medline (Ovid), China National Knowledge Infrastructure, and Wanfang databases were used for the literature search. The epidemiological studies published from January 2000 to June 2018 on high-risk HPVs in mainland Chinese women were investigated to systematically evaluate their epidemiological status. A total of 198 eligible studies were included. The results of metaanalysis showed that the overall infection rate of high-risk HPVs in mainland Chinese women was 19.0% (95% confidence interval [CI], 17.1%-20.9%), and the top 5 subtypes with the highest infection rates were 16, 52, 58, 53, and 18. The overall infection rates of cervical intraepithelial neoplasia I (CINI), CINII+, and cervical cancer patients were 59.6% (95% CI, 52.7%-66.4%), 84.8% (95% CI, 81.2%-88.5%), and 89.9% (95% CI, 86.6%-93.1%), respectively. The high-risk HPV infections and common subtypes in women of various ages in various regions were different, and the high-risk HPVs and subtypes in cervical cancer patients in various regions were also different. In conclusion, we systematically analyzed the HPV infections in women who live on the Chinese mainland. The epidemiology of high-risk HPVs in mainland Chinese women is basically consistent with that for the rest of the world. The HPV vaccines currently licensed in China could cover the major prevalent high-risk HPV subtypes in China, providing a basis for the development of cervical cancer screening strategy and the vaccine implementation in China.

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Prevalence and genotype distribution of cervical human papillomavirus (HPV) among women in urban Tianjin, China

Cited by 31 publications

References 33 publications

Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China

Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China

Age‐specific prevalence and genotype distribution of human papillomavirus in women from Northwest China

The distribution and prevalence of human papillomavirus in women in mainland China

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