Prevalence and Functional Role of Anti-IgE Autoantibodies in Urticarial Syndromes

Gruber, Barry L.; Baeza, M.L.; Marchese, Mary J.; Agnello, Vincent; Kaplan, Allen P.

doi:10.1111/1523-1747.ep12462239

Cited by 281 publications

(171 citation statements)

References 18 publications

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“…More than 20 years ago, functionally active autoantibodies to IgE and to the high-affinity IgE receptor (FcεRI) were first detected in the sera of CSU patients [1][2][3], and this appeared to be the most reasonable explanation for the pathogenesis of CSU. However, functional autoantibodies can be detected in approximately 40% of cases of CSU [2,3], and some sera from CSU patients lacking autoantibodies to FcεRI are able to induce histamine release from basophils cultured in vitro [4].…”

Section: Introductionmentioning

confidence: 99%

Detection of Low-Molecular-Weight Mast Cell–Activating Factors in Serum From Patients With Chronic Spontaneous Urticaria

Cugno¹,

Tedeschi²,

Frossi³

et al. 2016

J Investig Allergol Clin Immunol

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Background: Functionally active autoantibodies to IgE and to the high-affinity IgE receptor (FcεRI) can be detected in serum in about 40% of patients with chronic spontaneous urticaria (CSU). Recent studies showed that serum from patients with CSU can induce activation of mast cells, irrespective of whether they carry high-affinity IgE receptors. Objective: To evaluate mast cell activation induced by factors in the serum of CSU patients with a molecular weight lower than that of autoantibodies. Methods: Eight CSU patients and 5 healthy controls were evaluated. Whole serum and serum fractionated at 100, 50, and 30 kDa were used to stimulate in vitro LAD2 mast cells. The enzymatic activity of β-hexosaminidase was evaluated in supernatants and cell pellets as a measure of mast cell degranulation. Results: Mean (SEM) release of mast cell β-hexosaminidase induced by whole serum from CSU patients was higher than that induced by serum from the healthy controls (14.4 [2.7%] vs 5.1 [2.4%]; P=.027). In addition, serum fractions below 100 kDa and below 50 kDa from CSU patients induced mast cell degranulation that was significantly higher than that induced by the corresponding fractions in sera from healthy controls (10.2% [ Conclusions: This study shows that sera from CSU patients may contain low-molecular-weight mast cell-activating factors other than autoantibodies. These factors could be an additional mechanism contributing to the pathogenesis of CSU.

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Section: Introductionmentioning

confidence: 99%

Detection of Low-Molecular-Weight Mast Cell–Activating Factors in Serum From Patients With Chronic Spontaneous Urticaria

Cugno¹,

Tedeschi²,

Frossi³

et al. 2016

J Investig Allergol Clin Immunol

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“…There are several recognized immunologic degranulating stimuli that act through the IgE receptor, such as anti-IgE and anti-FcεRI antibodies. 12 Other non-immunologic stimuli including opiates, C5a anaphylatoxin, stem cell factor and some neuropeptides (e.g. substance P) can cause mast cell degranulation by binding specific receptors, independent of the FcεRI.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Autologous Serum Therapy in Chronic Urticaria: A Prospective Observational Study in Tertiary Care Hospital

Patel¹,

Gupta²,

Singh³

et al. 2016

jemds

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“…Furthermore, the direct cost of CU, in terms of healthcare visits, investigation and treatment, is high (20). Several aetiological factors have been associated with the onset of CU and it was suggested that the condition has an autoimmune basis (21,22). It was previously observed that IL-10 production was elevated and IL-2 reduced in CIU patients compared to healthy subjects (7).…”

Section: Discussionmentioning

confidence: 99%

Effects of the polysaccharide nucleic acid fraction of bacillus Calmette-Guérin on the production of interleukin-2 and interleukin-10 in the peripheral blood lymphocytes of patients with chronic idiopathic urticaria

Prevalence and Functional Role of Anti-IgE Autoantibodies in Urticarial Syndromes

Cited by 281 publications

References 18 publications

Detection of Low-Molecular-Weight Mast Cell–Activating Factors in Serum From Patients With Chronic Spontaneous Urticaria

Detection of Low-Molecular-Weight Mast Cell–Activating Factors in Serum From Patients With Chronic Spontaneous Urticaria

Effectiveness of Autologous Serum Therapy in Chronic Urticaria: A Prospective Observational Study in Tertiary Care Hospital

Effects of the polysaccharide nucleic acid fraction of bacillus Calmette-Guérin on the production of interleukin-2 and interleukin-10 in the peripheral blood lymphocytes of patients with chronic idiopathic urticaria

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