Prevalence and factors associated to vitamin A deficiency in children attending public day care centers in the Southwest of Bahia

Novaes, Taiane Gonçalves; Gomes, Andressa Tavares; Silveira, Karine Chagas; Souza, Cláudio Lima; Lamounier, Joel Alves; Netto, Michele Pereira; Capanema, Flávio Diniz; Rocha, Daniela da Silva

doi:10.1590/1806-93042016000300007

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…16 Our findings are similar to those of other studies conducted in Colombia and Brazil, [17][18] which reported that 24.3 % and 24.7 % of children aged between 1 and 5 years had VAD, and higher than those reported by other authors in the region. [19][20][21] Such differences in prevalence are probably a reflection of each country's or region's specific characteristics.…”

Section: Discussionmentioning

confidence: 99%

Vitamin A deficiency and associated factors in preschoolers from the outskirts of La Plata, Buenos Aires

et al. 2019

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Introduction. Vitamin A deficiency (VAD) has been recognized as an important public health problem in developing countries. Preschoolers account for risk groups within vulnerable populations. The objective of this study was to determine the prevalence of VAD and associated factors in a sample of preschoolers. Material and methods. Cross-sectional study with children aged 1-6 years receiving social assistance and seen at primary health care centers in the outskirts of the city of La Plata, Buenos Aires. Vitamin A levels were determined by measuring serum retinol with a liquid chromatography; anthropometric parameters and dietary intake were recorded. A multinomial logistic regression model was used to assess the association among outcome measures. Results. Data from 624 children were analyzed. The geometric mean of retinol was 23.8 μg/dL (95 % CI: 23.3-24.3). The prevalence of VAD and the risk for VAD were 24.3 % and 57.4 %, respectively. Retinol levels were significantly lower among boys, low-weight children, and those with low intake (below the first tertile of distribution). The multivariate analysis showed a significant association between VAD and male sex (odds ratio: 1.93; 95 % CI: 1.15-3.24) and between VAD and low intake (odds ratio: 1.48; 95 % CI: 1.15-2.62). Conclusion. The prevalence of VAD (24.3 %) is a major public health problem in this population. VAD-associated factors were male sex and low vitamin A intake.

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Section: Discussionmentioning

confidence: 99%

Vitamin A deficiency and associated factors in preschoolers from the outskirts of La Plata, Buenos Aires

et al. 2019

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“…16 Nuestros resultados son comparables a los de otros realizados en Colombia y Brasil, [17][18] que encontraron que el 24,3 % y el 24,7 % de los niños de entre 1 y 5 años tenían DVA, y superiores a los reportados por otros autores de la región. [19][20][21] Estas diferencias en las prevalencias, probablemente, reflejan las características particulares de cada país o región.…”

Section: Discussionunclassified

Deficiencia de vitamina A y factores asociados en niños preescolares de la periferia de la ciudad de La Plata, Buenos Aires

2019

Arch Argent Pediat

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“…Epidemiological data search shows that ZIKV-associated microcephaly is more frequent in areas with poor socioeconomic background with reports of malnutrition and deficits of vitamin A [4,5] and folate [6]. A screening based on these epidemiological data will be performed through common exams for cholesterol and fractions (as a marker of nutritional status) [38], vitamin A, and folate in blood of nine mothers of microcephalic children.…”

Section: "Reverse Engineering" To Reveal Co-factor Of Zikv-associated Microcephalymentioning

confidence: 99%

“…It is possible that a poor socioeconomic background correlates with the degree of severity of ZIKVassociated brain lesions due to nutritional or environment features [3]. Populations with higher incidence of ZIKV-associated microcephaly display higher incidence of malnutrition, vitamin A deficit [4,5], and folate deficit during pregnancy, for example [6]. Through different mechanisms, these nutritional alterations can lead to alterations in the placental barrier, fetal blood-brain barrier, and neurogenesis [7,8].…”

Section: Introductionmentioning

confidence: 99%

Co-factor Influences the Severity of Zika Virus-Associated Microcephaly

Nogueira¹,

Andrade²,

Zanini³

et al. 2021

Preprint

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Microcephaly has been regarded the most remarkable consequence of the Zika virus (ZIKV) epidemic in Brazil 2015. It remains to be determined whether there are factors that contribute to the degree of brain lesion associated with ZIKV infection during pregnancy. Previous studies showed that socioeconomic conditions correlate with ZIKV-associated microcephaly. Certain nutritional deficits display the potential to interfere in the mechanistic target of rapamycin (mTOR) signaling, which plays a major role in the pathophysiology of ZIKV-associated microcephaly. We hypothesize that a nutritional or environmental co-factor that interferes in mTOR signaling correlates with ZIKV-associated birth defects. To assess this hypothesis, we plan to: 1) develop a mouse model of ZIKV-associated microcephaly through intravenous injection of ZIKV and rapamycin for a straightforward interference on mTOR receptor; 2) determine in the experimental model and in cases of ZIKV-associated microcephaly the epigenetic signature (DNA methylation pattern) in neurons and muscle cells harvested by biopsy, and in hematopoietic and mesenchymal stem cells sorted from blood; 3) analyze through mass spectrometry in serum of pregnant female mice submitted to ZIKV and rapamycin injection and in serum of mothers of children with ZIKV-associated microcephaly the metabolomic pattern of cholesterol (a nutritional status marker), vitamin A and its metabolite retinoic acid, folate, and other metabolites related to these three nutritional factors; 4) check whether pregnant female mice submitted to intravenous injection of ZIKV and feed with a deficient diet of the most likely co-factor found in this study give birth to microcephalic mice with features that mimic clinical cases. In summary, our general objective is to develop an experimental model that mimics ZIKV-associated microcephaly cases and to find a co-factor involved in the microcephaly outbreak in Brazil 2015.

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Prevalence and factors associated to vitamin A deficiency in children attending public day care centers in the Southwest of Bahia

Cited by 4 publications

References 16 publications

Vitamin A deficiency and associated factors in preschoolers from the outskirts of La Plata, Buenos Aires

Vitamin A deficiency and associated factors in preschoolers from the outskirts of La Plata, Buenos Aires

Deficiencia de vitamina A y factores asociados en niños preescolares de la periferia de la ciudad de La Plata, Buenos Aires

Co-factor Influences the Severity of Zika Virus-Associated Microcephaly

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