Prevalence and evolution of Mycobacterium tuberculosis infection in tuberculosis case contacts

Albanese, Silvia Paulino Ribeiro; Costa, Arlete Alves Nunes Fragoso da; Pieri, Flávia Meneguetti; Alves, Elaine; Santos, Danielle Talita dos; Kerbauy, Gilselena; Arcêncio, Ricardo Alexandre; Dessunti, Elma Mathias

doi:10.1590/0037-8682-0014-2015

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…The prevalence of active TB before the 19 th century derived from the skeletal data (15-46%) is very high when compared to the current worldwide average TB prevalence, but it is plausible. In low-and middle-income countries, the current prevalence of LBTI is about 50% of the population, and in a household where a member is infected with TB, up to 30% of contacts will develop active TB (Albanese et al, 2015). For the 18th century, although historical documents did not document directly active TB prevalence rate, the other two indicators PMR-TB and MR-TB are consistent to its high values.…”

Section: Discussionmentioning

confidence: 93%

“…Resnick asserts that between 3% to 5% of active cases of TB will result in skeletal involvement (Resnick and Niwayama, 1988). Currently, about 30% of the world's population harbors latent TB infection (LTBI), and among these individuals, 5% will develop an active TB infection (Albanese et al, 2015). We did not use lower values proposed by Davidson and Horowitz (1970) that, when tested, provided inconsistent prevalence estimates.…”

Section: Methodsmentioning

confidence: 99%

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Was the rise of TB contemporaneous with the industrial revolution? Epidemiological evolution of TB in France (17th-20th centuries) inferred from osteoarchaeological and historical archives

Dutour

Colombo

Coqueugniot

2021

International Journal of Paleopathology

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Objective: The development of tuberculosis is classically associated with the rise of the Industrial Revolution. Our objective is to test this epidemiological hypothesis for populations in France between the 18th and 20th centuries using osteoarchaeological and historical sources.Materials: Osteoarchaeological sources include two skeletal collections from plague epidemics in Provence (1590 and 1722) representing a total of 349 individuals and medical archives dating 1750 to 1930 from Paris, Lyon, Marseille, Montpellier.Methods: Paleoepidemiological analysis (crude prevalence rate) of the archeological data, and epidemiological analysis of historical data included the proportional mortality rate of tuberculosis (PMR-TB) and the mortality rate by tuberculosis (MR-TB).Results: Mean prevalence of TB before the 19 th century was approximately 30%, according to osteoarchaeological data. Historical sources showed that pulmonary TB was responsible for 33% of total deaths in the city of Marseille during the second half of the 18 th century and represented about 20% of deaths in the four French cities during the 19 th century. The mortality rate was 6.5 per thousand inhabitants in the 18 th century (Marseille) and stable at 4 to 5 ‰ during the 19 th century before, during, and after the Industrial Revolution period, with the exception of years 1870-1871 (French-Prussian war), when it increased.Conclusions: Population increase contemporary to the industrialization process did not increase the mortality rate by tuberculosis in France. Significance:The epidemiological assertion that tuberculosis increased with the Industrial Revolution in cities must be reevaluated. In France, and perhaps in other cities, it was an endemic disease at least a century before, and associated with a higher mortality rate.Limitations: Reliability and biases inherent to archaeological and historical data prior and during the Industrial Revolution must be taken into account.

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Section: Discussionmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Was the rise of TB contemporaneous with the industrial revolution? Epidemiological evolution of TB in France (17th-20th centuries) inferred from osteoarchaeological and historical archives

Dutour

Colombo

Coqueugniot

2021

International Journal of Paleopathology

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“…A lower prevalence of LTBI was observed among Egyptian health care providers working in a high-risk TB environment diagnosed by TST and QFT assays ( El-Sokkary et al, 2015 ). A high prevalence of LTBI has been reported in many studies using different diagnostic tests, especially in countries with high TB disease burdens ( Abdulkareem et al, 2020, Abu-Taleb et al, 2011, Albanese et al, 2015, Eom et al, 2018, Hosten et al, 2018, Hu et al, 2012, Morrison et al, 2008, Narasimhan et al, 2017, Triasih et al, 2015.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Interferon Gamma-Induced Protein 10 mRNA Release Assay for Detection of Latent Tuberculosis Infection in Egyptian Pediatric Household Contacts

El-Sheikh

Mousa

Osman

et al. 2021

International Journal of Infectious Diseases

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Objectives: Current diagnostic tests for tuberculosis (TB) in children living in low-endemic countries are limited by low specificity and the inability of the current tests to differentiate between active TB and latent TB infection (LTBI). This study aimed to evaluate the blood IP-10 mRNA expression level to detect LTBI in Egyptian pediatric household contacts (PHC).Methods: TB-specific IP-10 and IFN-γ mRNA levels were assessed by real-time quantitative PCR (RT-qPCR) in 72 Egyptian PHC of active pulmonary TB cases. All study participants were also assessed by Tuberculin Skin Test (TST) and Quantiferon gold in tube (QFN-GIT) assay.Results: IP-10 and IFN-γ mRNA expression levels were significantly higher in PHC with active TB or LTBI than TB negative (p < 0.0 0 01). The level of IP-10 mRNA expression was significantly higher in PHC with active TB than LTBI (p = 0.0 0 08). In contrast, there was no significant differences in the IFN-γ mRNA expression between PHC with active TB compared to LTBI (p = 0.49). The sensitivity and specificity of the IP-10 RT-qPCR were 94.2% and 95.2%, respectively, in PHC with active TB compared to 85.7% and 81.8% in PHC with LTBI. The negative and positive predictive values and accuracy of IP-10 RT-qPCR for distinguishing active TB from LTBI were 85.2%, 58.3%, and 72.6% respectively. Conclusion:Blood IP-10 mRNA expression level may be a potential diagnostic marker to help distinguish active TB from LTBI in PHC.

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“…This is an intermediate prevalence rate compared with those observed in other Brazilian regions, where the variation (33.0-69.6%) was also higher than that found in our study. [20][21][22] If a TST cutoff point of 5 mm was considered, the prevalence of LTBI would be only slightly altered (from 21.2% to 22.2%) because only two children presented TST of 5-9 mm. Thus, the Divinópolis municipality remained with rates still below those reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Low Prevalence of Latent Tuberculosis Infection among Contacts of Smear-Positive Adults in Brazil

Oliveira-Cortez

Froede

Melo

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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This follow-up cross-sectional study aimed to analyze the prevalence rate and risk factors related to latent tuberculosis infection (LTBI) and active tuberculosis (TB) in children aged < 15 years in contact with adults with smearpositive pulmonary TB (PTB) in a Brazilian municipality. Data were collected from interviews, clinical evaluations, chest X-rays, tuberculin skin tests, and interferon gamma release assays. The median time elapsed between diagnosis of the index case (IC) and inclusion in the study was 2.5 years (interquartile range [IQR] = 1.5-4.4) and 7.4 years (IQR = 3.8-9.7) when we reassessed the development (or not) of active TB. The median age at the time of exposure to the IC was 6.6 years (IQR = 3.3-9.4) and 14.1 years (IQR = 8.9-17.7) at the last follow-up. Of the 99 children and adolescents in contact with smear-positive PTB, 21.2% (95% CI = 14.0-29.9) were diagnosed with LTBI, and none developed active TB. There was no statistically significant difference between the LTBI and non-LTBI groups regarding demographic, socioeconomic, and epidemiological characteristics. Unlike national and international scenarios, we found a lower frequency of LTBI and no active TB among our studied patients. For better understanding of these findings, further studies might add, among other factors, host and Mycobacterium tuberculosis genetic features.

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Prevalence and evolution of Mycobacterium tuberculosis infection in tuberculosis case contacts

Cited by 6 publications

References 9 publications

Was the rise of TB contemporaneous with the industrial revolution? Epidemiological evolution of TB in France (17th-20th centuries) inferred from osteoarchaeological and historical archives

Was the rise of TB contemporaneous with the industrial revolution? Epidemiological evolution of TB in France (17th-20th centuries) inferred from osteoarchaeological and historical archives

Assessment of Interferon Gamma-Induced Protein 10 mRNA Release Assay for Detection of Latent Tuberculosis Infection in Egyptian Pediatric Household Contacts

Low Prevalence of Latent Tuberculosis Infection among Contacts of Smear-Positive Adults in Brazil

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