Prevalence and distribution of human papillomavirus findings in swab specimens from gynaecology clinics of the east coast of Spain

Martorell, Miguel; García-García, José Ángel; Ortiz, Cristián; Pérez‐Vallés, Ana; Calabuig, Consuelo; Gómez-Cabrero, David; Escolano, Manuel; Montesinos, Manel

doi:10.3109/00365541003602056

Cited by 7 publications

(7 citation statements)

References 35 publications

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“…The distribution of HPV genotypes in this study was consistent with that reported in studies previously [20,29,30,34]. HPV16 has been consistently identified as the most frequent HR-HPV.…”

Section: Discussionsupporting

confidence: 91%

“…In Spain, crude prevalence rates for HPV infection in small, specific populations or in limited geographical areas have been previously reported to range from 3% to 17% [17][18][19][20]. In a study to provide specific information for Spain in 1,043 histologically confirmed invasive cervical cancer cases from six regions, 904 of these cases (89.1%) were HPV DNA positive [5].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Human Papillomavirus (HPV) Genotypes and Multiple Infections in Routine Cervical Cancer Screening in a Spanish Regional Population

Méndez¹

2013

SOJ Microbiol Infect Dis

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BackgroundCervical cancer is the second most common cancer in women worldwide and the most common cause of mortality in underdeveloped and developing countries [1,2]. Persistent infection with certain oncogenic high-risk (HR) types of Human Papillomavirus (HPV) is the required factor for the development of invasive cervical cancer and precursor lesions [3][4][5][6].Overall, the prevalence and distribution of HPV infection in cervical lesions has been determined in many geographical regions of the world, this can vary depending on several factors including epidemiological differences in the populations studied and the methodology used for molecular detection and typing of HPV DNA [7]. Over 120 types of HPV have been classified as either low (LR-HPV) or high risk (HR-HPV), according to their oncogenic potential [8,9]. Within the high-risk genotypes, HPV types 16 and HPV 18 are most often associated with cancer and squamous intraepithelial lesion [5,6,10,11,12]. Nevertheless, the risk of neoplasia for other types of HPV as well as for multiple HPV infection has not yet been established.Because current strategies for the prevention of cervical cancer and their precancerous lesions are based on the HPV genotyping [13] and prophylactic vaccines [14][15][16], it seems necessary to determine the types of HPV most commonly associated with malignant cell transformation in different geographical areas in order to establish effective preventive measures according to the epidemiology of the population. This study was to know the prevalence and distribution of cervical HPV infection in women attending routine cervical cancer screening in the Valencia region (Spain). Study designLiquid-based cytology (LBC) of cervical specimens was collected during routine screening visits, between June 20, 2011 and September 9, 2011 in the Clinical Hospital of Valencia, Spain. LBC samples were processed using the Thin Prep® 5000 processor (Madrid, Spain). For HPV detection and genotyping, we used the residual cervical sample material available from the same Thin Prep Pap test vial previously used for cytological screening. DNA was extracted from the residual materials of LBC by QIAamp® DNA mini kit (IZASA, Valencia, Spain), according to the manufacturer's instructions. HPV testing was performed by INNO-Lipa HPV genotyping Extra Reverse Hybridization Line Probe Assay kit (Innogenetics®, Barcelona, Spain), according to the manufacturer's instructions. Briefly, HPV detection and genotyping was based on PCR amplification of a 65pb fragment, within the L1 region of the HPV genome, using broad-spectrum SPF10 biotinylated primers. PCR was performed in a final AbstractBackground: Infection with human papillomavirus (HPV) has been identified as the primary cause of cervical cancer. Persistent infection with high risk-HPV is the required factor for the development of cervical cancer.

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“…The distribution of HPV genotypes in this study was consistent with that reported in studies previously [20,29,30,34]. HPV16 has been consistently identified as the most frequent HR-HPV.…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Prevalence of Human Papillomavirus (HPV) Genotypes and Multiple Infections in Routine Cervical Cancer Screening in a Spanish Regional Population

Méndez¹

2013

SOJ Microbiol Infect Dis

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show abstract

“…The prevalence of HPV infection found in the present study was higher than that observed in Spanish data published previously. Crude prevalence rates for HPV infection in small, specific populations or in limited geographical areas were reported previously to range from 3% to 17% [Muñoz et al, 1996; de Sanjosé et al, 2003; González et al, 2006; Bernal et al, 2008; Martorell et al, 2010].…”

Section: Discussionmentioning

confidence: 96%

“…HPV 16 has been identified consistently as the most common high‐risk HPV type. Other high‐risk HPVs detected frequently include types 51 and 31 [de Sanjosé et al, 2003; Ronco et al, 2005; Ammatuna et al, 2008; Agarossi et al, 2009; Agorastos et al, 2009; Giorgi Rossi et al, 2010; Martorell et al, 2010].…”

Section: Discussionmentioning

confidence: 99%

“…Reliable baseline estimates of the prevalence of type‐specific cervical HPV infections are essential for monitoring the early impact of HPV vaccination programs on circulating HPV genotypes in the population. The prevalence estimates reported in Spain ranged from 3% to 17% in five studies conducted between 1985 and 2007 [Muñoz et al, 1996; de Sanjosé et al, 2003; González et al, 2006; Bernal et al, 2008; Martorell et al, 2010]. However, no large‐scale epidemiological studies have been conducted in Spain.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and genotype distribution of human papillomavirus infection of the cervix in Spain: The CLEOPATRE study

Castellsagué

Iftner²,

Roura

et al. 2012

Journal of Medical Virology

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Human papillomavirus (HPV) infection is a necessary cause of cervical cancer. The aim of this study was to estimate the prevalence of cervical HPV infection and HPV type‐specific distribution among women attending cervical cancer screening in Spain during 2007 and 2008. Women aged 18–65 years were recruited according to an age‐stratified sampling method. Liquid‐based cervical samples were collected and analyzed for cytology, HPV detection, and genotyping. HPV genotyping was determined using the INNO‐LiPA HPV Genotyping Extra Reverse Hybridization Line Probe Assay. Prevalence estimates were age‐standardized using 2001 Spanish census data. The present study included 3,261 women. Age‐standardized HC2‐based HPV prevalence was 14.3% (95% CI, 13.1–15.5) among women aged 18–65 years, and 28.8% (26.6–31.1) among women aged 18–25 years. High‐risk HPV types were detected in 12.2% (95% CI, 11.1–13.4) of HPV‐tested women, representing 84.0% of HPV‐positive samples. Multiple infections were present in 4.1% (95% CI, 3.4–4.8) of HPV‐tested women (25.0% of HPV‐positive samples). The most common high‐risk HPV‐types among HPV‐tested women were 16 (2.9%), 52 (1.8%), 51 (1.6%), 31 (1.3%), and 66 (1.2%). HPV‐type 16 was present in 16.9% of HPV‐positive samples. One or more of the HPV vaccine types 6/11/16/18 were detected in 3.8% of HPV‐tested women (22.1% of HPV‐positive samples). Though not a true population‐based survey, this study provides valuable baseline data for future assessment of the impact of current HPV vaccination programs in Spain. The high prevalence of HPV infection among young women may reflect recent changes in sexual behavior. J. Med. Virol. 84:947–956, 2012. © 2012 Wiley Periodicals, Inc.

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82-Year-Old Female with Crusted, Eroded Plaques the Central Scalp

Hyman

Walker²,

Sampath³

et al. 2022

Clinical Cases in Alopecia

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Prevalence and distribution of human papillomavirus findings in swab specimens from gynaecology clinics of the east coast of Spain

Cited by 7 publications

References 35 publications

Prevalence of Human Papillomavirus (HPV) Genotypes and Multiple Infections in Routine Cervical Cancer Screening in a Spanish Regional Population

Prevalence of Human Papillomavirus (HPV) Genotypes and Multiple Infections in Routine Cervical Cancer Screening in a Spanish Regional Population

Prevalence and genotype distribution of human papillomavirus infection of the cervix in Spain: The CLEOPATRE study

82-Year-Old Female with Crusted, Eroded Plaques the Central Scalp

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