Prevalence and determinants of elevated high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy

Abstract

The results demonstrated that hs-cTnT was elevated in a significant number of our HCM patients; therefore, hs-cTnT can be introduced as a valuable marker of myocardial injury in HCM patients.

Significance and Determinants of Cardiac Troponin I in Patients With Obstructive Hypertrophic Cardiomyopathy

“…Previous studies have also shown that cardiac troponins are significantly associated with LA dimensions in HC. 7,9,10,12 Combined with the positive correlations between serum cTnI and LV volume (LVEDVI and LVESVI) found in this study, which have also been indicated by Okamoto et al, 11 we speculate that serum cardiac troponins in HC may be partially related to increased LV-filling pressures.…”

Measurement of Troponin in Cardiomyopathies

“…37 Exercise can increase Tn levels. 38 Clinical correlates: troponin elevation in HCM is associated with greater LV wall thickness 37,[39][40][41][42][43] and LV mass. [44][45][46] Two studies found Tn elevation in patients with LV outflow tract obstruction 37,42 but another found no correlation.…”

“…38 Clinical correlates: troponin elevation in HCM is associated with greater LV wall thickness 37,[39][40][41][42][43] and LV mass. [44][45][46] Two studies found Tn elevation in patients with LV outflow tract obstruction 37,42 but another found no correlation. 40 The natural history of HCM includes progression to heart failure and Tn elevation is present in those with LV systolic dysfunction 37,40,44 although the degree of hs-TnT elevation does not correlate linearly with ejection fraction.…”

“…37,40 Diastolic dysfunction, usually an earlier feature in HCM is also associated with Tn release. Several studies report correlations between Tn and left atrial (LA) area or diameter 37,42,46 as well as filling pressure measured by the ratio between early diastolic mitral inflow velocity and early diastolic mitral annular velocity (E/Ea) 40,42 It is uncertain whether Tn can help detect the presence of paroxysmal atrial fibrillation (AF) with studies reporting both a positive 40,47 and negative association. 42,46 More recently Tn levels have been related to the presence and extent of late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR).…”

Comparison of High-Sensitive Cardiac Troponin-T Changes between Non-ST-Segment Elevation Myocardial Infarction and Non-Coronary Artery Patients

“…In addition, there are several noncoronary-related conditions, known to cause an increase in cTn, which should be considered in the differential diagnosis of patients presenting with troponin elevation (5)(6)(7)(8). Also, there are several factors which can influence the upper reference limits of hs-cTnT (97.5th and 99th…”