Prevalence and determinants of depression among multi drug resistant (MDR) TB cases registered under national tuberculosis elimination program in Ahmedabad City

Sharma, Rashmi; Bakshi, Harsh; Prajapati, Shailesh T.; Bhatt, GneyaaS; Mehta, Rajesh; Rami, KiranC; Mehta, Prakash; Shah, Tejas; Dave, Roshni; Peerzada, Azba

doi:10.4103/ijcm.ijcm_813_21

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…This can lead to increased levels of stress and anxiety and an increased risk of depression. We founds significant association between family issues and depression in MDR-TB patients, our findings are in agreement with a study 14 which reported similar findings.…”

Section: Discussionsupporting

confidence: 93%

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Prevalence and Determinants of Depression Among Multi Drug Resistant (MDR) TB Cases

Ayub¹,

Khan²,

Kumari³

et al. 2023

PJMHS

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Aim: We aimed this study to find the prevalence of depression among multi drug resistant (MDR) TB patients and its related determinants. Material and methods: An observational cross-sectional study was conducted at Jinnah Postgraduate Medical Center Karachi hospital, we enrolled 107 MDR-TB patients using non-probability consecutive sampling. Patients were evaluated for depression using Patient Health Questionnaire-9 (PHQ-9). Prevalence of depression along with its determinant were assessed. We used Chi Square test for association between depression and its determinants keeping P value < 0.05 was taken as statistically significant. Results: Patients’ mean age was 32.10±6.19, male patients were higher in number as compared to female patients. In our study we found that depression was present in 52 (48.6%) patients. Depression had significant association with financial issues, family problems, treatment duration and increasing age. Practical implication: Current study assess the determinants of depression in TB patients and spreads public awareness in community about Multidrug resistance in TB and ways to avoid TB in local population. Conclusion: From our study we conclude that 52 (48.6%) patients had depression in MDR-TB patients which is an alarming situation. Financial issues, family problems, treatment duration and increasing age were found to the determinants of depression in MDR-TB patients. Keywords: Tuberculosis, Multi Drug Resistance, Depression, Truenat, Xpert, Mental disorders, psychiatric comorbidity

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Section: Discussionsupporting

confidence: 93%

“…A study from India however reported a low prevalence of depression in TB patients 16.2. 14 A study 18 conducted in Nepal reported the prevalence of TB 62.7% which is comparable to our findings.…”

Section: Discussionsupporting

confidence: 89%

Prevalence and Determinants of Depression Among Multi Drug Resistant (MDR) TB Cases

Ayub¹,

Khan²,

Kumari³

et al. 2023

PJMHS

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“…4 Several factors cause TB cases to soar continuously, including the presence of Coronavirus disease (COVID- 19), nonadherence to treatment, and lack of public understanding. [5][6][7] Additionally, in low-middle-income nations, where TB remains prevalent, there are inadequate healthcare services, limited drug supply, not diagnosed/underdiagnosed cases, and a lack of reporting of suspected cases by the community due to insufficient information, all of which contribute to an increase in TB cases. 8,9 Improving understanding of how TB is transmitted has the potential to mitigate misconceptions and biases, and simultaneously alleviate stigmatization.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitudes, and Perceptions of Tuberculosis in Indonesia: A Multi-Center Cross-Sectional Study

Kaaffah¹,

Kusuma²,

Renaldi³

et al. 2023

IDR

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Introduction Tuberculosis (TB) is still a persistent health challenge in Indonesia and ranks high on the list of factors causing morbidity and mortality. Improving knowledge, attitudes, and perceptions (KAP) of the general community about TB can help to control the disease. Purpose This study aimed to examine the KAP about TB in Indonesian society and investigate their sociodemographic determinants. Participants and Methods An online cross-sectional survey in 34 provinces in Indonesia was carried out in June 2022. The scores of KAP were classified as low, moderate, and high. Bivariate and multivariate ordinal logistic regression were applied to identify the potential sociodemographic determinants of KAP. Adjusted odds ratio and 95% confidence interval (CI) for each determinant were provided. Results Among the 3205 participants, 56.4%, 91%, and 38% had high scores on knowledge, attitude, and perception, respectively. Independent determinants of high knowledge were age (26–35 years; adjusted odds ratio: 1.53 [95% CI: 1.19–1.97]), marital status (married; adjusted odds ratio: 1.18 [95% CI: 1.00–1.39]), and salary (middle income; adjusted odds ratio: 0.76 [95% CI: 0.63–0.93]). Independent factors associated with high scores in attitude and perception were the residence location (village; adjusted odds ratio: 0.76 [95% CI: 0.59–0.98]) and the occupation type (civil servant; adjusted odds ratio: 1.53 [95% CI: 1.09–2.13]), respectively. Conclusion Most Indonesians have a high knowledge and good attitude, although they have a moderate perception toward TB. Improving public awareness and health education with the right strategies is critical to reducing the country’s TB burden.

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“…A regional ethnography also revealed profound grief and despair in the patient narratives. Feelings of isolation and despair appear to be common responses to an MDR-TB diagnosis [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Mental Health Impacts of Multidrug-Resistant Tuberculosis in Patients and Household Contacts: A Mixed Methods Study

Murugan,

Patel,

Kumar

et al. 2024

Cureus

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Background: Multidrug-resistant tuberculosis (MDR-TB) patients experience disproportionately worse mental health, with implications for adherence, outcomes, and families. Comprehensive assessments of comorbid depression/anxiety and related factors remain limited. Objective: This study aimed to assess the prevalence, predictors, and qualitative experiences of depression and anxiety in MDR-TB patients and household contacts. Methods: A sequential explanatory mixed methods study was conducted in Gujarat, India, with 403 smear-positive MDR-TB patients and 403 contacts. The quantitative phase administered structured questionnaires on sociodemographic factors, clinical history, depression/anxiety symptoms, and psychosocial stressors (like stigma and social support). Logistic regression models were used. The qualitative phase included in-depth interviews with 30 purposively sampled patients for thematic content analysis. Results were integrated to contextualize quantitative findings. Results: High rates of depression (37.5%, n = 151) and anxiety (45.2%, n = 182) were documented among the MDR-TB patients, significantly greater than household contacts (20.1%, n = 81 and 25.1%, n = 101, respectively). For depression, older age (adjusted odds ratio (AOR) 2.03, 95% CI 1.01-4.05), female gender (AOR 2.5, 95% CI 1.1-6.0), divorced/widowed status (AOR 3.8, 95% CI 1.1-8.0), financial constraints, substance abuse (AOR 1.7, 95% CI 1.1-2.7), greater disease severity (AOR 1.8, 95% CI 1.5-2.2), medication side effects (AOR 2.4, 95% CI 1.2-4.6), and perceived stigma (AOR 3.2, 95% CI 1.1-5.3) emerged as significant risk factors. For anxiety, significant predictors were less social support (AOR 0.81, 95% CI 0.71-0.86), higher perceived stigma (AOR 2.2, 95% CI 1.1-6.3), greater disease severity (AOR 2.6, 95% CI 1.3-4.0), and more medication side effects (AOR 3.3, 95% CI 1.1-5.5). Prominent themes included psychological impacts like depression and anxiety, experiences of stigma and caretaking challenges, and recommendations for comprehensive patient support services. Conclusion: MDR-TB patients experience a substantially higher dual disease burden of depression and anxiety, elevating the risk for adverse outcomes and transmission. Improving psychosocial support is vital to patient-centric care pathways for vulnerable groups. Mixed methods provide comprehensive evidence to inform integrated physical and mental health services.

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Prevalence and determinants of depression among multi drug resistant (MDR) TB cases registered under national tuberculosis elimination program in Ahmedabad City

Cited by 7 publications

References 12 publications

Prevalence and Determinants of Depression Among Multi Drug Resistant (MDR) TB Cases

Prevalence and Determinants of Depression Among Multi Drug Resistant (MDR) TB Cases

Knowledge, Attitudes, and Perceptions of Tuberculosis in Indonesia: A Multi-Center Cross-Sectional Study

Mental Health Impacts of Multidrug-Resistant Tuberculosis in Patients and Household Contacts: A Mixed Methods Study

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