Prevalence and demographic characteristics of comorbid epilepsy in children and adolescents with cerebral palsy: a nationwide population-based study

Chiang, Kuo-Liang; Kuo, Fang-Chuan; Cheng, Chen-Yang; Chang, Kuo-Ting

doi:10.1007/s00381-018-3920-9

Cited by 13 publications

(18 citation statements)

References 47 publications

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“…28 Extensive brain injury in CP patient affecting cortex, deep white matter, and central nuclei provide a reason for them to develop epilepsy. A study in China stated that epilepsy incidence is influenced by geographic position and socio-economic condition [29] that can relate with Indonesia condition, especially Surabaya. Among those with epilepsy, statistically, female has bigger risk developing epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Profile of Cerebral Palsy Patients in Dr. Soetomo General Hospital Surabaya, Indonesia

Salfi

Saharso

Atika

2019

BHSJ

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Introduction: Limited profile data of Cerebral Palsy (CP) patients in Indonesia leads CP to be a less-known disease. The aim of this study is to describe CP patient’s characteristics, including demographic aspect, gestation and birth history, and CP related condition in Dr. Soetomo General Hospital Surabaya, Indonesia.Methods: Cross-sectional study using medical records of CP patients in Dr. Soetomo General Hospital (Surabaya, Indonesia) Outpatient Installation for Pediatric Neurology from January 2016 to June 2018. Data processed descriptively.Results: From total 107 patients, 50 subjects met inclusion criteria. Mean age was 6.16 years old, with domination of male (3:2), live in Surabaya (56%), malnourished (24%), normal birth weight (80.9%), term age of birth (66.7%), spontaneous labor (60%), and also prenatal events as causes of Cerebral Palsy (69.5%). Pneumonia was found to be most among postnatal events leading to Cerebral Palsy (30%). Most of the type was spastic (9:1) with quadriplegic as the dominating one (64%). Congenital malformation was rarely found (38%), but co-morbidities were found in almost all sample (92%).Conclusion: Gestation and birth history of CP patients are mostly ranged normal. Prenatal etiology is found dominating as the cause of CP, therefore emendation in antenatal care (ANC) shall be considered. Analytical study about CP in Indonesia also must be improved because it is still hardly found.

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Section: Discussionmentioning

confidence: 99%

Profile of Cerebral Palsy Patients in Dr. Soetomo General Hospital Surabaya, Indonesia

Salfi

Saharso

Atika

2019

BHSJ

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“…16 However, for the most severe categories, the issue is how much the seizure disorder is already 'baked into' measures of survival, given that the Australian Cerebral Palsy Register 17 found that 65% of children in GMFCS level V at age 5 years had a seizure disorder. In Taiwan, 18 there was a seizure prevalence over all GMFCS levels of 30%, but with no subdivisions. My personal experience is that more than 95% of all children in the TF/CLH category seen for medicolegal reasons had a diagnosed seizure disorder.…”

Section: M Pac T Of Seiz U R E Disor Der S On Life E X Pec Ta Nc Y I ...mentioning

confidence: 97%

Life expectancy and its adjustment in cerebral palsy with severe impairment: Are we doing this right?

Rosenthal

2021

Develop Med Child Neuro

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Life expectancy and its adjustment in cerebral palsy with severe impairment: Are we doing this right? In children with very severe cerebral palsy, an adversarial legal process for medical negligence, when liability is admitted, requires an estimate of life expectancy. Medical experts using the same cohort data and the same clinical facts can produce quite different life expectancies, leading to arguments in legal conferences and courts. The issues that commonly arise include between‐country comparisons, projected and therapy‐induced advanced life expectancies, and the contribution of epilepsy, scoliosis, and especially cognition to life expectancy. In this review, these factors are discussed from an arithmetic, statistical, and medical viewpoint to initiate debate on the issue, including whether median survival should be advocated.

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“…With regard to gender, there are a higher percentage of males with a diagnosis of CP than females, as was reported in the literature [20], and observed in this study. This higher prevalence in males is related to variants in the interleukin (IL)-6 gene, greater vulnerability with regard to the protective function of hormones, polymorphisms, and brain structure [2,20], with higher susceptibility for the default quadriplegic pattern [19].…”

Section: Discussionmentioning

confidence: 99%

“…Epilepsy is characterized by recurrent seizures and is one of the most prevalent comorbidities in individuals with CP, in whom it is considered a marker of CP severity [2]. The prevalence of epilepsy is estimated to be 77% in individuals with CP [3].…”

Section: Introductionmentioning

confidence: 99%

Mandible bone density in adolescents with cerebral palsy using antiepileptic drugs

et al. 2022

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Objective:The aim of this study was to assess the bone density of the mandible in adolescents with cerebral palsy (CP) treated with antiepileptic drugs using one beam computed tomography (CBCT). Methods: The study was carried out with 18 adolescents aged 12-18 years, undergoing routine dental treatment at the dental clinic of APCD-São Caetano do Sul. CBCT scans were of divided into two groups: G1 adolescents with CP using antiepileptic drugs and G2 normoactive adolescents. A single dentomaxillofacial radiologist assessed and evaluated the images using Dental Slice software and Image J. Fisher's exact tests as well as paired and unpaired Student's t-tests were performed. Results: Groups differed significantly with regard in the values of density (p < 0.001), with G1 presenting lower values compare to G2. G1 showed significantly lower density means on the right side, left side, and right/left sides of the mandible edge than G2 (p < 0.001). Conclusion: CP patients using antiepileptic drugs show evidence of bone mineral density loss of the mandible.

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Prevalence and demographic characteristics of comorbid epilepsy in children and adolescents with cerebral palsy: a nationwide population-based study

Abstract: SES and geographic variables were significantly associated with the risk of epilepsy in children with CP. Patients with epileptic CP had a higher odds ratio of several neuropsychiatric diseases, including mental retardation, ophthalmologic problems, hearing impairment, and hydrocephalus.

Cited by 13 publications

References 47 publications

Profile of Cerebral Palsy Patients in Dr. Soetomo General Hospital Surabaya, Indonesia

Profile of Cerebral Palsy Patients in Dr. Soetomo General Hospital Surabaya, Indonesia

Life expectancy and its adjustment in cerebral palsy with severe impairment: Are we doing this right?

Mandible bone density in adolescents with cerebral palsy using antiepileptic drugs

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