Prevalence and correlates of vitamin K deficiency in children with inflammatory bowel disease

Nowak, Jan Krzysztof; Grzybowska-Chłebowczyk, Urszula; Landowski, Piotr; Szaflarska-Popławska, Anna; Klincewicz, Beata; Adamczak, Daria M.; Banasiewicz, Tomasz; Pławski, Andrzej; Walkowiak, Jarosław

doi:10.1038/srep04768

Cited by 45 publications

(27 citation statements)

References 23 publications

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“…VitK1 can be obtained from, e.g., meats, cheeses, and eggs or synthetized (VitK2) by the microbiota of the colon de novo or from VitK1 ( 236 , 247 , 248 ). VitK deficiency has been associated with both adult and pediatric CD patients ( 249 ). A protective role of VitK was shown in a model of DSS-induced colitis associated with a reduction in IL-6 production from B cells ( 250 ).…”

Section: Nutrients and Their Impact On Microbiota And Immune Responsementioning

confidence: 99%

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

et al. 2017

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Recent findings point toward diet having a major impact on human health. Diets can either affect the gut microbiota resulting in alterations in the host’s physiological responses or by directly targeting the host response. The microbial community in the mammalian gut is a complex and dynamic system crucial for the development and maturation of both systemic and mucosal immune responses. Therefore, the complex interaction between available nutrients, the microbiota, and the immune system are central regulators in maintaining homeostasis and fighting against invading pathogens at mucosal sites. Westernized diet, defined as high dietary intake of saturated fats and sucrose and low intake of fiber, represent a growing health risk contributing to the increased occurrence of metabolic diseases, e.g., diabetes and obesity in countries adapting a westernized lifestyle. Inflammatory bowel diseases (IBD) and asthma are chronic mucosal inflammatory conditions of unknown etiology with increasing prevalence worldwide. These conditions have a multifactorial etiology including genetic factors, environmental factors, and dysregulated immune responses. Their increased prevalence cannot solely be attributed to genetic considerations implying that other factors such as diet can be a major contributor. Recent reports indicate that the gut microbiota and modifications thereof, due to a consumption of a diet high in saturated fats and low in fibers, can trigger factors regulating the development and/or progression of both conditions. While asthma is a disease of the airways, increasing evidence indicates a link between the gut and airways in disease development. Herein, we provide a comprehensive review on the impact of westernized diet and associated nutrients on immune cell responses and the microbiota and how these can influence the pathology of IBD and asthma.

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Section: Nutrients and Their Impact On Microbiota And Immune Responsementioning

confidence: 99%

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

et al. 2017

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“…In vivo studies show that high-fat/high-sugar diets cause microbial dysbiosis, decreased mucus layer thickness, increased permeability, and increased susceptibility to colonization with pathogenic E. coli (135). Modulation of the gut microbiota in IBD influences the levels of critical vitamins and minerals in IBD patients, such as the bioavailability of vitamin K (136). A decreased prevalence of butyrate-producing bacteria, such as Clostridiales species, in IBD patients with active disease explains the decreased amounts of SCFA (such as butyrate) in their fecal samples, which would normally contribute to inhibition of E. coli growth in IBD (134,137).…”

Section: Role Of Diet In Controlling Bacterial Contributions To Ibdmentioning

confidence: 99%

Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease

et al. 2019

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SUMMARYGut bacteria play a key role in initiating and maintaining the inflammatory process in the gut tissues of inflammatory bowel disease (IBD) patients, by supplying antigens or other stimulatory factors that trigger immune cell activation. Changes in the composition of the intestinal microbiota in IBD patients compared to that in healthy controls and a reduced diversity of intestinal microbial species are linked to the pathogenesis of IBD. Adherent invasiveEscherichia coli(AIEC) has been linked to Crohn’s disease (CD) patients, while diffusely adherentE. coli(DAEC) has been associated with ulcerative colitis (UC). Bacteriological analysis of intestinal biopsy specimens and fecal samples from IBD patients shows an increased number ofE. colistrains belonging to the B2 phylogenetic group, which are typically known as extraintestinal pathogenicE. coli(ExPEC). Results from studies of both cell cultures and animal models reveal pathogenic features of theseE. colipathobionts, which may link them to IBD pathogenesis. This suggests that IBD-associatedE. colistrains play a facilitative role during IBD flares. In this review, we explain IBD-associatedE. coliand its role in IBD pathogenesis.

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“…In this sense, identifying the biological functions that require VK is critical. Nowadays, VK is quite well known in vertebrates to be required for blood coagulation [ 35 , 36 , 37 ], skeletal and joint tissues [ 19 , 38 , 39 , 40 , 41 , 42 ], and pathological calcification and inflammation [ 37 , 43 , 44 , 45 ]. There are some reports on their potential role on redox homeostasis [ 41 , 46 , 47 ], sphingolipid [ 48 , 49 ] and glucose metabolism [ 50 ], neural development and cognitive capacities [ 20 , 48 , 51 , 52 ], as well as angiogenesis [ 53 ].…”

Section: Vitamin K Metabolites Sources and Metabolismmentioning

confidence: 99%

Vitamin K in Vertebrates’ Reproduction: Further Puzzling Pieces of Evidence from Teleost Fish Species

2020

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Vitamin K (VK) is a fat-soluble vitamin that vertebrates have to acquire from the diet, since they are not able to de novo synthesize it. VK has been historically known to be required for the control of blood coagulation, and more recently, bone development and homeostasis. Our understanding of the VK metabolism and the VK-related molecular pathways has been also increased, and the two main VK-related pathways—the pregnane X receptor (PXR) transactivation and the co-factor role on the γ-glutamyl carboxylation of the VK dependent proteins—have been thoroughly investigated during the last decades. Although several studies evidenced how VK may have a broader VK biological function than previously thought, including the reproduction, little is known about the specific molecular pathways. In vertebrates, sex differentiation and gametogenesis are tightly regulated processes through a highly complex molecular, cellular and tissue crosstalk. Here, VK metabolism and related pathways, as well as how gametogenesis might be impacted by VK nutritional status, will be reviewed. Critical knowledge gaps and future perspectives on how the different VK-related pathways come into play on vertebrate’s reproduction will be identified and proposed. The present review will pave the research progress to warrant a successful reproductive status through VK nutritional interventions as well as towards the establishment of reliable biomarkers for determining proper nutritional VK status in vertebrates.

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Prevalence and correlates of vitamin K deficiency in children with inflammatory bowel disease

Cited by 45 publications

References 23 publications

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease

Vitamin K in Vertebrates’ Reproduction: Further Puzzling Pieces of Evidence from Teleost Fish Species

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