Prevalence and correlates of herpes simplex virus type 2 infection: evaluation of behavioural risk factors

Laar, M J W van de; Termorshuizen, Fabian; Slomka, Marek J.; Doornum, G. J. J. Van; Ossewaarde, Jacobus M.; Brown, David; Coutinho, R. A.; Hoek, Janet

doi:10.1093/ije/27.1.127

Cited by 68 publications

(47 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several sexual behavioral factors were observed, in this study, to be significantly contributory to the high HSV-2 prevalence, in keeping with the assertion that the presence of HSV-2 antibodies is a marker of indiscrete sexual behavior [28,29]. It is therefore instructive that the following considerations should be included in individual case management and primary prevention strategies: more than one sex partner in the past 12 months; more than one lifetime sex partner; early sexual exposure; involvement in polygamous marriages; and use of hormonal contraceptives.…”

Section: Discussionsupporting

confidence: 90%

Sexual behavioral correlates with HSV-2 seroprevalence among pregnant women in Nigeria

Kalu

Ojide

Fowotade

et al. 2014

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: The burden of HSV-2 infection, the cause of most cases of genital herpes in Nigeria, varies from region to region; and so are the associated factors. This infection is known to be responsible for several negative pregnancy outcomes. There is currently no documented data on sexual behavioral factors associated with the occurrence of HSV-2 infection or seroprevalence among pregnant women in Nigeria. This study aimed at identifying the sexual behavioral correlates of HSV-2 seroprevalence among pregnant women in Benin City, Nigeria. Methodology: The cross-sectional study design was adopted and the study took place between November 2011 and June 2012. Four hundred and ten consenting ante-natal clinic patients in two major tertiary hospitals in Benin City were consecutively and prospectively included. Data sources were represented by questionnaires, the patient's case records and laboratory investigations. Each patient's serum was analyzed for HSV-2 antibody detection. Data analysis was performed using SPSS version 16. Results: Four hundred and ten patients were enrolled with average age 30.6 years. Seroprevalence of HSV-2 antibody was 47.3%. Sexual behavioral factors that were significantly associated with HSV-2 seroprevalence included early exposure to sexual intercourse, number of sex partners, involvement in polygamous marriages, involvement of husband in extra-marital affairs and hormonal contraceptive use. Conclusion: The prevalence of HSV-2 among pregnant women in Benin City is high. Public health campaigns aimed at: delaying onset of sexual activity; encouraging monogamous relationships; and emphasizing that hormonal contraceptives do not protect from STI's, are recommended.

show abstract

Section: Discussionsupporting

confidence: 90%

Sexual behavioral correlates with HSV-2 seroprevalence among pregnant women in Nigeria

Kalu

Ojide

Fowotade

et al. 2014

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…According to the 1988 to 1994 NHANES III survey, HSV-2 seroprevalence in the cross-section of the U.S. population sampled had risen to over 20%, reflecting an increase of over 30% in a single decade (10). The seroprevalence is higher for patients being seen in sexually transmitted disease (STD) clinics (25 to 65%) (21,28,31,34), for prostitutes (78%), and for homosexual men in the United States (83%) (28), populations generally considered high risk for having STDs. Regional, racial, and gender-related differences in seroprevalence have similarly been noted (10,16).…”

mentioning

confidence: 99%

Six-Year Study of the Incidence of Herpes in Genital and Nongenital Cultures in a Central Kentucky Medical Center Patient Population

Ribes¹,

Steele²,

Seabolt

et al. 2001

J Clin Microbiol

View full text Add to dashboard Cite

Herpes infections are among the most common sexually transmitted diseases and are the most common cause of genital ulcer disease in the United States. This study addresses the changing distribution of herpes simplex virus type 1 (HSV-1) and HSV-2 in patients presenting for evaluation of herpetic infections. Viral culture results from the University of Kentucky Clinical Microbiology Laboratory were reviewed for a 6-year period (1994 through 1999). Data were collected on patient sex, site of culture, and culture result. These data were analyzed statistically to identify yearly trends. Of the 4,498 cultures analyzed, nearly equal proportions of HSV-1 (13.3%) and HSV-2 (12.0%) were detected for an overall culture positivity rate of 25.3%. Approximately two-thirds of all positive cultures were from women. Although HSV-2 remained the predominant type of genital herpes, over the 6-year span of this study, there was a trend toward increasing proportions of HSV-1 genitalis, with 31.8% of male patients and 44.8% of female patients demonstrating HSV-1 genitalis by 1999. The majority of patients with HSV in nongenital sites grew HSV-1. Although there was significant yearly variation, HSV-2 was isolated from only 9.4% of patients with nongenital HSV for the entire 6-year period. This study therefore concludes that HSV-2 remains primarily a genital pathogen, while HSV-1 is taking on an increasingly important role in causing genital ulcer disease in addition to being the primary nongenital HSV.

show abstract

“…These findings were found to be comparable with that of van de Laar MJ et al study group where in a strong independent association with the presence of HSV-2 antibodies was found for sexual behaviour, more specifically homosexual orientation, increasing number of years of sexual activity, increasing number of lifetime partners, number of past gonococcal infections, having receptive anal and (or) vaginal contact. 19 Among HBsAg positive cases in the present study, most cases were heterosexuals, followed by homosexuals. These findings were found to be comparable with that of Ledy HS Oliveira et al study where in 95.4% related to have heterosexual life style and 3.6% were homo/bisexuals.…”

Section: Sexual Behaviourmentioning

confidence: 44%

SEROPREVALENCE OF HSV, HBsAg & HCV IN STD CLINIC ATTENDEES OF A TERTIARY CARE STATE HEADQUARTERS HOSPITAL

Godha¹,

S²,

Kumari³

et al. 2017

jemds

View full text Add to dashboard Cite

BACKGROUNDSexual activity in humans is meant for both procreative and recreational purposes. However, with the discovery of HIV/AIDS in 1981, concerns developed worldwide over unprotected sex. The unprotected sexual activity is contributing for transmission of symptomatic and asymptomatic STIs such as HIV, HBsAg and HCV.The aim is to study seroprevalence of HBsAg, HSV & anti-HCV antibodies in STD clinic attendees of Osmania Medical College/ Osmania General Hospital, Hyderabad. MATERIALS AND METHODSIt is a descriptive study (observational study) conducted from January 2015 -December 2015 at STD Clinic OPD. A total of 3,583 patients who attended the STD Clinic during the above period were studied and patients having direct or indirect risk factors were serotested for the 3 viral infections after inclusion and exclusion criteria with informed consent. A 5 mL of venous blood is collected and the separated serum is tested for HSV 1&2, HBsAg and Anti-HCV antibodies by using ELISA kits. It is ensured that the test kits used have >95% sensitivity and specificity. Settings & Design-All eligible patients attending STD Clinic, Dept. of DVL, Osmania Medical College/Osmania General Hospital, Hyderabad were included in the study after inclusion and exclusion criteria with informed consent. A consecutive sampling methodology with zero intervals is followed. A percentage analysis method is used to derive the conclusions. RESULTSA total of 473 cases are found to be seropositives out of the 3,583 STD clinic attendees for either of 3 STIs showing a seroprevalence of 13.20%, in which male seroprevalence is 13.56% (258 cases) and female seroprevalence is 12.80% (215 cases).In the studied population of 3583, 412 cases were seropositives for HSV Antibodies with seroprevalence of 11.5%, 39 were HBsAg Antibodies positive with seroprevalence of 1.09% and 22 cases were positive for HCV antibodies with seroprevalence of 0.61%. The seropositivity in males and females respectively for HSV is 11.56% and 11.43%; for HBsAg is 1.26% and 0.89%; for HCV is 0.74% and 0.48%. The illiterates (376 of 473=79.49%) and people of low socioeconomic status (371 of 473=78%) are more affected. While 234 of 258 men are having either Premarital, Extramarital or combination accounting to 90.70%, 176 of 215 (81.86%) women are confined to marital sex. CONCLUSIONThe awareness on STIs needs to be well informed before the start of the sexual activity by incorporating the STI/RTI education in school and college curriculum, through IEC activities like mass media campaigns, print & electronic media, by using local cultural festivals, gatherings and through marriage institutions. The at-risk populations such as Sex workers, MSM & IDUs should be covered through specific targeted interventions by utilising NGOs, local bodies and associations.

show abstract

Prevalence and correlates of herpes simplex virus type 2 infection: evaluation of behavioural risk factors

Abstract: The presence of HSV-2 antibodies had a strong association with past sexual behaviour and, for both sexes, with receptive anal intercourse. HSV-2 antibodies may be used as a surrogate marker of sexual risk behaviour in comparing different populations over time.

Cited by 68 publications

References 10 publications

Sexual behavioral correlates with HSV-2 seroprevalence among pregnant women in Nigeria

Sexual behavioral correlates with HSV-2 seroprevalence among pregnant women in Nigeria

Six-Year Study of the Incidence of Herpes in Genital and Nongenital Cultures in a Central Kentucky Medical Center Patient Population

SEROPREVALENCE OF HSV, HBsAg & HCV IN STD CLINIC ATTENDEES OF A TERTIARY CARE STATE HEADQUARTERS HOSPITAL

Contact Info

Product

Resources

About