Background
Compared to HIV-negative women, HIV-infected women have increased risk of low birth weight (LBW) and preterm delivery (PTD). We assessed whether severity of maternal HIV-1 disease was associated with LBW or PTD.
Methods
Secondary analysis of The Malaria and HIV in Pregnancy prospective cohort, which enrolled HIV-positive, pregnant Malawian women from 2000–2004. Included participants (n=809) were normotensive, antiretroviral treatment naïve women who delivered a live, singleton infant. Binomial regression models were used to assess the unadjusted and adjusted prevalence ratios (PRs) and 95% confidence intervals (CI) of the effect of severity of HIV-1 disease, defined by viral load and CD4-positive T-cell counts, on prevalence of LBW and PTD.
Results
In unadjusted analyses, among those with malaria (n=198), there was no association between severity of HIV-1 infection and LBW, while among women without malaria (n=611), we observed a harmful association between both increasing peripheral viral load and LBW (PR: 1.44 per one-log10 increase, 95% CI: 1.12, 1.86) and placental viral load and LBW (PR: 1.24 per one-log10 increase, 95% CI: 1.00, 1.53). We observed a similar association between increasing placental viral load and PTD (PR: 1.33 per one-log10 increase, 95% CI: 1.04, 1.69). These associations persisted in multivariate models adjusted for residence, maternal education, primigravid status, and maternal anemia.
Conclusions
In malaria-negative women, maternal HIV-1 disease severity was significantly associated with increased prevalence of LBW and PTD. Such an association was not found in the malaria-infected women.