Prevalence and clinicopathological comparison of kerotocystic odontogenic tumor and orthokeratinized odontogenic cyst in South Indian sample population: A retrospective study over 13 years

Abstract

Aim and Methodology:The purpose of this study is to determine the prevalence of keratocystic odontogenic tumor (KCOT) and orthokeratinized odontogenic cyst (OOC), to identify their clinicopathological features among the patients by studying the biopsy specimens obtained from the archives of the Department of Oral and Maxillofacial Pathology, College of Dental Sciences, Davangere, Karnataka, India during the period of 2001-2013. Data for this study is retrieved from the case records of the patients fitting the histological classification of the World Health Organization (2005). The following clinical variables, namely age, gender, anatomical location, and histological features are analyzed.Results:Of the 3026 biopsy reports (100%) present in the archives, we had 31 cases (1.02%) of KCOT, 11 cases (0.36%) of OOC and a combination of para and orthokeratinized lining epithelium made 1 case (0.033%). The most frequent clinical manifestation was asymptomatic followed by the combination of pain and swelling. The male: female ratio was 1.4:1 with a mean age of 30 years in KCOT, while 2.7:1 with a mean age of 29.1 years in OOC. Posterior molar-ramus region was most commonly involved in both KCOT and OOC.Conclusion:Due to aggressiveness and high recurrence rate of KCOT, differentiation between KCOT and OOC is important, with respect to their treatment modalities. Such epidemiological pools are also essential for the analysis of geographical distribution of odontogenic tumours

Orthokeratinized odontogenic cyst (OOC): Clinicopathological and radiological features of a series of 10 cases

“…These authors also noted that due to the aggressiveness and high recurrence rate of KCOT compared to OOC, the differentiation between them is important with respect to their treatment modalities. Their results showed that the clinical features of the two entities resembled each other but histological features were distinct [18]. Bharathi et al also published a case report of OOC and reviewed the literature [19].…”

Orthokeratinized odontogenic cyst associated with multinucleated giant cell reaction: report of unusual findings

“…Foreign body multinucleated giant cells arise from an inflammatory response resulting from the persistent presence of a non-phagocytable material 13 .…”

Comparison of cytokeratin expressions among orthokeratinized odontogenic cysts, epidermoid cysts and odontogenic keratocysts: An immunohistochemical study

“…[ 10 11 ] OKCs arise from the remnants of dental lamina and are the third-most common type of odontogenic cyst in a study from the Indian population. [ 12 ] It may present as pain in the jaw, soft-tissue swelling and paresthesia of lip/teeth or may be asymptomatic as it tends to grow in an anteroposterior direction within the medullary cavity of the bone without causing obvious bone expansion. Distinctive clinical features include potential for local destruction and a tendency for multiplicity, especially when the lesion is associated with nevoid basal-cell carcinoma syndrome syndrome.…”