Prevalence and Clinicopathologic Findings of Conjunctival Epithelial Neoplasia in Pterygia

Artornsombudh, Pichaporn; Sanpavat, Anapat; Tinnungwattana, Uraiwan; Tongkhomsai, Varangkana; Sansopha, Lalana; Tulvatana, Wasee

doi:10.1016/j.ophtha.2012.12.020

Cited by 24 publications

(15 citation statements)

References 26 publications

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“…However, no data currently exists to indicate whether subclinical and unsuspected OSSN will result in clinical disease; i.e., it is not possible to demonstrate an absolute correlation between the histopathological abnormality and the biological potential of the lesion (7) . There may also be genetic factors that influence the rate of transformation to neoplasia in pterygia among different populations (15) . In our group of patients, there was no suspicion of OSSN before surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Because OSSN and pterygia share risk factors, it is not surprising that they often occur concomitantly in the same eye. As shown in table 1, the incidence of coexistent pterygia and ocular surface disorders such as OSSN varies depending on the geographic location (6)(7)(8)(9)(10)(11)(12)(13)(14)(15) . The clinical characteristics of pterygia patients who have unsuspected OSSN does not appear to differ from those who are free of the condition.…”

Section: Introductionmentioning

confidence: 99%

“…The clinical characteristics of pterygia patients who have unsuspected OSSN does not appear to differ from those who are free of the condition. Thus, it is difficult to diagnose these patients based on clinical characteristics alone (15) . Impression cytology (IC), a method for the evaluation of superficial cell layers in the diagnosis (16) and treatment follow-up of several ocular surface tumors (17) , has exhibited squamous metaplasia with goblet cells in specimens obtained from pterygia (18)(19) .…”

Section: Introductionmentioning

confidence: 99%

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Use of impression cytology for the detection of unsuspected ocular surface squamous neoplasia cells in pterygia

Barros¹,

Lowen²,

Moraes-Filho³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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Purpose: To evaluate the agreement between the methodologies of impression cytology (IC) and histopathology regarding epithelial lesions clinically diagnosed as pterygium and also regarding the detection of unsuspected and associated ocular surface squamous neoplasia (OSSN). Methods: Thirty-two Brazilian patients were included and IC was performed on all pterygia before excision. Histopathogical examination was considered the gold standard and was performed by two experienced ocular pathologists in which consensus existed regarding pterygia diagnosis. IC accuracy was assessed by sensitivity and specificity with a 95% confidence interval. Results: From the 32 primary lesions studied, histopathological examination confirmed the diagnosis of pterygium without atypical cells in 19 cases (60%) and showed unsuspected and associated OSSN cells in 13 cases (40%). IC demonstrated one false-negative and one false-positive result for atypia. Statistical analysis showed an estimated sensitivity of 92%, specificity of 94%, positive predictive value of 92%, and negative predictive value of 94%. Conclusion: IC demonstrated high agreement with histopathological analysis in the detection of atypical epithelial cells in unsuspected OSSN in Brazilian pterygia patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Use of impression cytology for the detection of unsuspected ocular surface squamous neoplasia cells in pterygia

Barros¹,

Lowen²,

Moraes-Filho³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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“…Esta frecuencia menor del 2% es similar a la encontrada en Tailandia (18) , EE.UU. (8) y Canadá (17) .…”

Section: Discussionunclassified

“…A nivel mundial, el examen histopatológico obligatorio de muestras conjuntivales ha dado lugar a investigaciones que evalúan la frecuencia de NESO no sospechada en especímenes de pterigión (15)(16)(17)(18) . Específicamente en Perú, no se han realizado estudios de esta naturaleza.…”

Section: Introductionunclassified

Neoplasia escamosa de la superficie ocular en pacientes con pterigión en Perú

Furuya‐Kanamori

Dulanto-Reinoso

Stone

et al. 2014

Rev Peru Med Exp Salud Publica

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Objetivos. Estimar la frecuencia de neoplasia escamosa de la superficie ocular (NESO) no sospechada en pterigión, la precisión del diagnóstico clínico y las características demográficas y clínicas asociadas. Materiales y métodos. Se examinaron los informes histopatológicos de los pacientes con diagnóstico clínico de pterigión y/o NESO que fueron quirúrgicamente tratados entre marzo de 2009 y diciembre de 2012 en el Instituto Nacional de Oftalmología en Lima, Perú. La precisión del diagnóstico clínico para identificar la NESO se evaluó mediante la sensibilidad, especificidad y los cocientes de probabilidad. Se realizaron modelos de regresión log-log negativos para identificar las características demográficas y clínicas asociadas con un aumento de las probabilidades de diagnosticar NESO. Resultados. Se examinaron 3021 informes de histopatología. La frecuencia de NESO no sospechada en pterigión fue de 0,65%. El diagnóstico clínico presentó una sensibilidad del 85%, una especificidad del 99%, un cociente de probabilidad positiva de 111,89 y un cociente probabilidad negativa de 0,15. Las características asociadas fueron el sexo masculino (OR 1,15; IC 95%:1,01-1,30), pacientes de 61 a 80 años (OR 1,54; IC 95%: 1,28-1,85), ≥ de 81 años (OR 3,10; IC 95%: 2,09-4,58), pacientes con lesiones recurrentes (OR 1,59; IC 95%: 1,03-2,46) y lesiones en el lado temporal (OR 3,57; IC 95%: 2,63-4,85) presentaron mayor probabilidad de NESO. Conclusiones. Se encontró una baja frecuencia de NESO no sospechada, sin embargo, es recomendable realizar el estudio histopatológico de forma rutinaria para evitar diagnósticos erróneos de NESO como pterigión. Palabras clave: Pterigion; Neoplasias oculares; Diagnóstico clínico (fuente: DeCS BIREME). SQUAMOUS NEOPLASIA OF THE OCULAR SURFACE IN PATIENTS WITH PTERYGIUM IN PERU ABSTRACTObjectives. To estimate the frequency of unsuspected ocular surface squamous neoplasia (OSSN) in pterygium, the accuracy of clinical diagnosis, and associated demographic and clinical characteristics. Materials and methods. We reviewed histopathological reports of patients with a clinical diagnosis of pterygium and/or OSSN who were surgically treated between March 2009 and December 2012 at the National Eye Institute in Lima, Peru. The accuracy of the clinical diagnosis of OSSN was assessed by sensitivity, specificity, and likelihood ratios. Models of negative log-log regression were performed to identify demographic and clinical characteristics associated with increased odds of diagnosing OSSN. Results. 3,021 histopathological reports were reviewed. The frequency of unsuspected OSSN in pterygium was 0.65%. Clinical diagnosis had a sensitivity of 85%, a specificity of 99%, a positive likelihood ratio of 111.89, and a negative likelihood ratio of 0.15. Associated characteristics were male gender (OR =1.15; 95% CI: 1.01 to 1.30), age group of 61-80 years (OR = 1.54, 95% CI: 1.28 to 1.85) ≥ 81 years (OR = 3.10; 95% CI: 2.09 to 4.58), presence of recurrent lesions (OR = 1.59; 95% CI: 1.03 to 2.46) and temporal location lesi...

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Pathology of the Conjunctiva

Milman

2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

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Prevalence and Clinicopathologic Findings of Conjunctival Epithelial Neoplasia in Pterygia

Cited by 24 publications

References 26 publications

Use of impression cytology for the detection of unsuspected ocular surface squamous neoplasia cells in pterygia

Use of impression cytology for the detection of unsuspected ocular surface squamous neoplasia cells in pterygia

Neoplasia escamosa de la superficie ocular en pacientes con pterigión en Perú

Pathology of the Conjunctiva

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