Neoplasia escamosa de la superficie ocular en pacientes con pterigión en Perú

Furuya‐Kanamori, Luis; Dulanto-Reinoso, Carlos M.; Stone, Jennifer; Marroquín, Lelia; Dulanto-Reinoso, Victor Ch.; Roca, José A.; Contreras, Francisco Ganga; Lee, Graham

doi:10.17843/rpmesp.2014.314.119

Cited by 4 publications

(1 citation statement)

References 32 publications

(41 reference statements)

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“…A study performed in Lima, Peru, observed a 0.66% frequency of OSSN from 2891 samples clinically diagnosed pterygium. 23 A study from Toronto, Canada, of 1127 consecutive pterygia specimens over an 8year period, observed no cases of OSSN in their cohort. 24 Prolonged UV radiation through sunlight exposure has been implicated in the pathophysiology of both OSSN and pterygium.…”

Section: Discussionmentioning

confidence: 98%

Histopathological Rate of Ocular Surface Squamous Neoplasia in Clinically Suspected Pterygium Specimens: 10-Year Results

Modabber¹,

Lent-Schochet

Li³

et al. 2021

Cornea

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The aim of this study was to evaluate the prevalence of histopathologically confirmed ocular surface squamous neoplasia (OSSN) in clinically diagnosed pterygium samples at a tertiary center in Northern California, over a 10-year period (2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019).Methods: A retrospective chart review of patients older than 18 years with clinically diagnosed benign pterygium requiring excision was conducted. Clinically suspected pterygia were excised using standard techniques and routinely submitted to the University of California Davis for pathologic evaluation. Demographic, clinical, surgical, and pathological information were recorded and analyzed. The prevalence rate of OSSN was calculated.Results: A total of 348 consecutive specimens were evaluated. The mean (6SD) age of the patients was 58 6 12 years, with a near equal sex representation. A total of 57 (16%) pterygia were recurrent at initial presentation. Histopathologic results demonstrated a single case of OSSN. This patient did not have a documented history of carcinoma in other organs or any history of herpes virus, human papilloma virus, or human immunodeficiency virus infection. Conclusions:The prevalence of histopathological OSSN in clinically suspected pterygia within our sample was approximately 0.3%. Because of shared clinical characteristics of pterygia and OSSN, a high index of suspicion and judicious use of anterior segment optical coherence tomography enable for effective preoperative diagnosis of OSSN. However, in the absence of clinical expertise or high-resolution optical coherence tomography, routine tissue pathologic examination may be warranted.

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Section: Discussionmentioning

confidence: 98%

Histopathological Rate of Ocular Surface Squamous Neoplasia in Clinically Suspected Pterygium Specimens: 10-Year Results

Modabber¹,

Lent-Schochet

Li³

et al. 2021

Cornea

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Ocular Surface Squamous Neoplasia with Coexistent Pterygia: A Study of 14 Cases and Review of Literature

S Vempuluru,

Heroor,

Chheda

et al. 2024

Seminars in Ophthalmology

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Histopathological Variability and Concomitant Lesions in Pterygium in a Large Case Series

Bergeron

Ito

Dossous

et al. 2021

Journal of Ophthalmology

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Pterygium is a common lesion consisting of fleshy conjunctival growth extending towards the cornea. There is no documented risk of malignant transformation; however, concomitant disease is not rare, and its link to sunlight exposure indicates a risk of other malignancies. The purpose of our study is to describe histopathological features of resected pterygiums and to recognize patients at risk of other conjunctival diseases. One hundred and forty-nine formalin-fixed and paraffin-embedded pterygium samples were subjected to histopathological analysis. Histological H&E sections were obtained and digitalized using a Zeiss Axio Scan.Z1 slide scanner. Thirteen predefined morphological features were used to record histopathological changes in the epithelium and substantia propria. Neovascularization was observed in 54% of the samples. Sun damage, comprising solar elastosis and stromal plaque, was present in 81% of the samples. Variation in epithelial thickness was the most common change, with acanthosis and atrophy being observed in 62% and 26% of the samples, respectively. In our series, 21% (31/149) of pterygiums showed mild to moderate dysplasia, a finding that may be associated to ocular surface squamous neoplasia (OSSN). Moreover, 32% (47/149) of the cases showed melanocytic hyperplasia, which could represent primary acquired melanosis (PAM). There is a positive correlation between dysplasia and chronic inflammation p = 0.012 and an inverse correlation with epithelial atrophy p = 0.001 and neovascularization p = 0.05 . Similarly, a positive correlation is observed between goblet cell hyperplasia and melanocytic hyperplasia p = 0.02 . Our findings show that pterygiums harbour histological features that may be suggestive of OSSN or PAM in 53% of our patients. Whilst being on the benign side of the spectrum, these two entities are known for their potential progression to malignancy. A recommendation is made for all surgically excised pterygiums to be sent for histopathological diagnosis, and clear guidelines for reporting of these lesions should be established. Associated histopathological findings suggestive of other concomitant diseases should be identified to insure adequate follow-up of these patients.

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Neoplasia escamosa de la superficie ocular en pacientes con pterigión en Perú

Cited by 4 publications

References 32 publications

Histopathological Rate of Ocular Surface Squamous Neoplasia in Clinically Suspected Pterygium Specimens: 10-Year Results

Histopathological Rate of Ocular Surface Squamous Neoplasia in Clinically Suspected Pterygium Specimens: 10-Year Results

Ocular Surface Squamous Neoplasia with Coexistent Pterygia: A Study of 14 Cases and Review of Literature

Histopathological Variability and Concomitant Lesions in Pterygium in a Large Case Series

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