Prevalence and clinical characteristics of patients with obsessive-compulsive disorder in first-episode psychosis

Abstract

BackgroundObsessive-compulsive disorder (OCD) in patients with psychotic disorders has been reported to be a frequent co-morbid disorder in patients with psychotic disorders. The aim of the study determine the prevalence of OCD in first-episode psychosis and the relationship with clinical characteristics.MethodsFirst-episode psychosis patients (N = 246) consecutively admitted to a comprehensive early psychosis program were assessed for OCD with the Structured Clinical Interview for DSM-IV. Symptom assessment measures were the Positive and Negative Syndrome Scale, Global Assessment of Functioning, and the Clinician Rating Scale.ResultsTwenty-six patients (10.6%) fulfilled the criteria for OCD. Patients with comorbid OCD were younger, had more depressive symptoms and a higher rate of suicidal plans or attempts at index point compared to patients without OCD. The two groups did not differ with respect to other demographic variables or severity of psychotic symptoms.ConclusionOCD is a significant comorbid disorder in patients with first-episode psychosis. Since treatment procedures are different, systematic screening for OCD is warranted.

Associations of obsessive–compulsive symptoms with clinical and neurocognitive features in schizophrenia according to stage of illness

“…Th e p resen t findings that schizoph renia patients w ith obsessive-com pulsive sym ptom s show ed greater subjective and objective depressive sym ptom s th an did th ose w ith out obsessivecom pulsive sym ptom s during both stages are com parable w ith m any previous studies (Fenton and McGlash an, 1986;Niendam et al, 20 09;de Haan et al, 2013a;Schirm beck et al, 2013b). Associations betw een com orbid obsessive-com pulsive sym ptom s and depression in patients w ith sch izophrenia have been con sisten tly observed from th e early stage of illn ess regardless of association s betw een obsessive-com pulsive sym ptom s and psych otic severity (de Haan et al, 20 05, 2013a;Hagen et al, 2013). Furtherm ore, an association of com orbid obsessive-com pulsive sym ptom s w ith depression w as observed in individuals at UHR of psychosis, as m easured prior to psych osis on set or in a very early stage of sch izophren ia (Niendam et al, 2009;Fon tenelle et al, 2011;DeVylder et al, 2012).…”

Suicidality in clozapine-treated patients with schizophrenia: Role of obsessive-compulsive symptoms

“…Significant association between the Y-BOCS total score and the CDSS score was found as well. This finding has been consistently reported in literature (de Haan et al, 2005(de Haan et al, , 2013Hagen et al, 2013). Also, we found a trend towards higher Y-BOCS score in patients with higher clozapine dosage.…”

The effect of obsessive compulsive symptoms on psychopathology in patients with schizophrenia

“…Two years ago, a group of researchers again proved that patients suffering from schizophrenia with OCS had significantly higher scores in both the Positive and Negative Syndrome Scale (PANSS) and Beck Depression Inventory (BDI) when compared to the non-OCS group 8 . Furthermore, higher rates of suicidal plans or attempts were also found among these patients 9,10 . There were findings from various studies to suggest that schizophrenia with OCS might be a distinct subtypes of schizophrenia 7,11,12 ; and that OCS itself was considered as one of the core clinical features and symptom domains of schizophrenia rather than being an additional clinical condition 6 .…”

“…In some of the previous studies, it was reported that schizophrenia patients with OCS were associated with more severe psychopathology 7,8 and depressive symptoms 9,10,40,53 . Our study findings are consistent with these previous studies, as our patients also had more psychotic symptoms and higher depressive symptom scores.…”