Associations of obsessive–compulsive symptoms with clinical and neurocognitive features in schizophrenia according to stage of illness

Kim, Sung‐Wan; Jeong, Bo-Ok; Kim, Jae-Min; Shin, Il‐Seon; Hwang, Mei‐Yuh; Amminger, G. Paul; Nelson, Barnaby; Berk, Michael; McGorry, Patrick D.; Yoon, Jin‐Sang

doi:10.1016/j.psychres.2015.01.021

Cited by 17 publications

(15 citation statements)

References 68 publications

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“…In terms of the socio-demographic factors between schizophrenia patients with OCS and those without, we observed that the duration of illness is not significantly associated with the presence of OCS in schizophrenia. This is in contrast with previous studies which reported that the longer the illness, the higher the prevalence of OCS in schizophrenia 2,8,42 . As expected, the usage of clozapine in schizophrenia was associated with high OCS, a finding consistent with previous studies 25, [43][44][45] .…”

Section: Discussioncontrasting

confidence: 99%

“…However, these findings were not reproducible in subsequent studies, which found that schizophrenia with OCS had actually worse outcomes 6,7 . Two years ago, a group of researchers again proved that patients suffering from schizophrenia with OCS had significantly higher scores in both the Positive and Negative Syndrome Scale (PANSS) and Beck Depression Inventory (BDI) when compared to the non-OCS group 8 . Furthermore, higher rates of suicidal plans or attempts were also found among these patients 9,10 .…”

Section: Introductionmentioning

confidence: 99%

“…During acute episodes of psychosis, it would also be very difficult to discern obsessions from delusions of schizophrenia 31 . In addition, some studies had used different definitions for clinically significant OCS resulted in a non-homogenous recruitment of study participants 8,32 , while some researchers had shown that both obsessive-compulsive disorder (OCD) and schizophrenia with OCS were no different in terms of their obsessive and compulsive symptom structures 18 .…”

Section: Introductionmentioning

confidence: 99%

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The effect of obsessive compulsive symptoms on psychopathology in patients with schizophrenia

Seng¹,

Yee²,

Danaee³

et al. 2018

Arch. Clin. Psychiatry (São Paulo)

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Background: There is a growing interest on the impact of comorbid obsessive-compulsive symptoms (OCS) on the course and severity of schizophrenia in recent years. Objectives: This study determined the prevalence of OCS in schizophrenia patients and the clinical outcomes of the comorbidity. Methods: A total of 220 schizophrenia patients were recruited. All the participants completed Structure Clinical Interview version, Yale Brown Obsessive Compulsive Scale, Calgary Depression Scale for Schizophrenia, Columbia Suicide Severity Rating Scale and World Health Organization Quality of Life-Brief Version (WHOQOL-BREF). Results: Significantly higher number of schizophrenia patients with OCS were taking Clozapine (p = 0.023) and antidepressants (p = 0.013). Schizophrenia patients with OCS showed more severe positive (p < 0.001) and general symptoms (p < 0.001) of schizophrenia, higher depressive symptoms (p = 0.013), higher suicidality (p < 0.001), more hospitalization (p = 0.044), poorer physical (p = 0.034) and psychological (p = 0.032) domain in WHOQOL-BREF. Discussion: Schizophrenia patients with OCS are associated with more severe psychopathology and depressive symptoms which subsequently suffered poorer physical and psychological health. Hence, recognition of OCS in schizophrenia and early initiation of effective treatment may be able to reduce the burden for people with chronic mental illness.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of obsessive compulsive symptoms on psychopathology in patients with schizophrenia

Seng¹,

Yee²,

Danaee³

et al. 2018

Arch. Clin. Psychiatry (São Paulo)

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“…This observation is supported by a recent meta‐analysis of brain structural case‐control differences across multiple disorders that also failed to identify diagnosis‐specific effects [Goodkind et al, ]. A common biological substrate provides an explanation for the symptomatic overlap in the disorders examined here [Beesdo et al, ; Buckley et al, ; Eisen and Rasmussen, ; Kim et al, ; OConghaile and DeLisi, ; Pearlson, ; Rosen et al, ]. The transdiagnostic overlap in brain activation abnormalities also resonates with behavioral observations of shared transdiagnostic cognitive deficits that are present at or before disease onset [Shanmugan et al, ; Koenen et al, ], and with transdiagnostic overlap of genetic risk factors [Cross‐disorder group of the PGC, 2013; Doherty and Owen, ].…”

Section: Discussionsupporting

confidence: 70%

“…However, there are significant differences in the relative prevalence of symptoms across the disorders examined here. For example, OCD symptoms may be present in about 18% of patients with SCZ [Kim et al, ] and psychotic experiences are reported by about 14% of patients with OCD [Eisen and Rasmussen, ]. Our findings suggest that the relationship between abnormalities in task‐related networks to symptoms is both complex and unclear.…”

Section: Discussionmentioning

confidence: 99%

Addressing reverse inference in psychiatric neuroimaging: Meta‐analyses of task‐related brain activation in common mental disorders

Sprooten

Rasgon

Goodman

et al. 2017

Human Brain Mapping

180

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Functional magnetic resonance imaging (fMRI) studies in psychiatry use various tasks to identify case‐control differences in the patterns of task‐related brain activation. Differently activated regions are often ascribed disorder‐specific functions in an attempt to link disease expression and brain function. We undertook a systematic meta‐analysis of data from task‐fMRI studies to examine the effect of diagnosis and study design on the spatial distribution and direction of case‐control differences on brain activation. We mapped to atlas regions coordinates of case‐control differences derived from 537 task‐fMRI studies in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorders, and obsessive compulsive disorder comprising observations derived from 21,427 participants. The fMRI tasks were classified according to the Research Domain Criteria (RDoC). We investigated whether diagnosis, RDoC domain or construct and use of regions‐of‐interest or whole‐brain analyses influenced the neuroanatomical pattern of results. When considering all primary studies, we found an effect of diagnosis for the amygdala and caudate nucleus and an effect of RDoC domains and constructs for the amygdala, hippocampus, putamen and nucleus accumbens. In contrast, whole‐brain studies did not identify any significant effect of diagnosis or RDoC domain or construct. These results resonate with prior reports of common brain structural and genetic underpinnings across these disorders and caution against attributing undue specificity to brain functional changes when forming explanatory models of psychiatric disorders. Hum Brain Mapp 38:1846–1864, 2017. © 2017 Wiley Periodicals, Inc.

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Schizotypal and obsessive–compulsive traits: Co‐occurrence rate and relationship with executive function, emotion experience, and emotion expressivity in college students

et al. 2020

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Empirical findings suggest that there is an overlap between schizophrenia and obsessive-compulsive disorder (OCD). These disorders also have a high comorbidity rate. However, little is known about the impact of co-occurring schizotypal and obsessive-compulsive traits on executive function, emotion experience, and emotion expressivity in the normal population. The present study examined the prevalence of coexisting schizotypal and obsessive-compulsive traits and the relationship between these two traits in a sample of healthy college students. We also conducted a moderation analysis to explore the effect of these two type of traits on executive function, emotion experience, and emotion expressivity. We recruited 3,319 participants to complete the Schizotypal Personality Questionnaire (SPQ) and the Obsessive-Compulsive Inventory-Revised (OCI-R). A subset of them (n = 575) also completed the Chinese versions of the Dysexecutive Questionnaire (DEX), the Temporal Experience of Pleasure Scale (TEPS), and the Emotional Expressivity Scale (EES). We found that the prevalence of co-occurring schizotypal and OCD traits was 3.33%. All the subscales of the SPQ and the OCI-R significantly correlated with each other. Both traits had a negative impact on executive function and emotion expressivity. The interaction between the disorganization dimension of schizotypal traits and OCD traits had a significant effect on executive function, but not emotion experience or emotion expressivity. This study was limited by its cross-sectional design and recruitment of only college students. These findings suggest that there is an approximately 3% rate of co-occurring schizotypal and obsessive-compulsive traits in a healthy college student sample. The interaction between these two types of traits may influence executive function.

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Associations of obsessive–compulsive symptoms with clinical and neurocognitive features in schizophrenia according to stage of illness

Cited by 17 publications

References 68 publications

The effect of obsessive compulsive symptoms on psychopathology in patients with schizophrenia

The effect of obsessive compulsive symptoms on psychopathology in patients with schizophrenia

Addressing reverse inference in psychiatric neuroimaging: Meta‐analyses of task‐related brain activation in common mental disorders

Schizotypal and obsessive–compulsive traits: Co‐occurrence rate and relationship with executive function, emotion experience, and emotion expressivity in college students

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