Prevalence and characteristics of pseudodrusen subtypes in advanced age-related macular degeneration

Shijo, Taiyo; Sakurada, Yoichi; Yoneyama, Seigo; Sugiyama, Atsushi; Kikushima, Wataru; Tanabe, Naohiko; Iijima, Hiroyuki

doi:10.1007/s00417-017-3622-0

Cited by 14 publications

(8 citation statements)

References 13 publications

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“…Genomic DNA was extracted from peripheral blood samples and purified using a Puregene DNA Isolation Kit (Gentra Systems, Minneapolis, MN, USA). Genotyping was performed using TaqMan genotyping assays with a 7300/7500 Real-Time PCR System (Applied Biosystems, Foster City, CA, USA) in accordance with the manufacturer’s recommendations, as recently described 37 .…”

Section: Methodsmentioning

confidence: 99%

Comparison of two-year outcomes after photodynamic therapy with ranibizumab or aflibercept for polypoidal choroidal vasculopathy

Kikushima

Sakurada

Sugiyama

et al. 2017

Sci Rep

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Photodynamic therapy (PDT) combined with intravitreal anti-vascular endothelial growth factor (VEGF) agents is currently the first-line treatment for polypoidal choroidal vasculopathy (PCV), along with anti-VEGF monotherapy. In this study, 100 eyes with treatment-naïve PCV were initially treated with PDT combined with intravitreal ranibizumab (IVR; n = 57) or aflibercept (IVA; n = 43). We compared two-year outcomes between these two groups and investigated factors associated with visual improvement and retreatment over 24 months. Best-corrected visual acuity (BCVA) was significantly improved in both groups (P < 0.001) at 24 months. Multiple regression analysis revealed that visual improvement at 24 months was associated with female (P = 0.030), worse baseline BCVA (P = 3.0 × 10−6), smaller greatest linear dimension (GLD; P = 2.0 × 10−4), and treatment with IVA rather than IVR (P = 0.016). Multiple logistic regression analysis revealed that absence of retreatment was associated with younger age (P = 2.2 × 10−4), female (P = 1.2 × 10−3), and the non-risk variants of ARMS2 A69S (P = 6.0 × 10−4). Although there were no significant differences in the retreatment rate between the two groups, PDT/IVA may be superior to PDT/IVR in terms of visual improvement at 24 months.

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Section: Methodsmentioning

confidence: 99%

Comparison of two-year outcomes after photodynamic therapy with ranibizumab or aflibercept for polypoidal choroidal vasculopathy

Kikushima

Sakurada

Sugiyama

et al. 2017

Sci Rep

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“… 67 It was found that the prevalence of GA was associated with the presence of ribbon-dominant (confluent)-type pseudodrusen, large soft drusen, and female gender. 68 Pigmentary disturbances are a frequent finding in AMD that can be in the form of either focal hyperpigmentation or hypopigmentation. Progressive well-demarcated atrophic patches of the RPE may appear in the perifoveal area.…”

Section: Clinical Features and Diagnosismentioning

confidence: 99%

Recent developments in age-related macular degeneration: a review

Al-Zamil¹,

Yassin²

2017

CIA

330

251

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Background: Visual impairment in elderly people is a considerable health problem that significantly affects quality of life of millions worldwide. The magnitude of this issue is becoming more evident with an aging population and an increasing number of older individuals. Objective: The objective of this article was to review the clinical and pathological aspects of age-related macular degeneration (AMD), diagnostic tools, and therapeutic modalities presently available or underway for both atrophic and wet forms of the disease. Methods: An online review of the PubMed database was performed, searching for the key words. The search was limited to articles published since 1980 to date. Results: Several risk factors have been linked to AMD, such as age (.60 years), lifestyle (smoking and diet), and family history. Although the pathogenesis of AMD remains unclear, genetic factors have been implicated in the condition. Treatment for atrophic AMD is mainly close observation, coupled with nutritional supplements such as zinc and antioxidants, whereas treatment of wet AMD is based on targeting choroidal neovascular membranes. Conclusion: Identification of modifiable risk factors would improve the possibilities of preventing the progression of AMD. The role of anti-vascular endothelial growth factor (anti-VEGF) agents has transformed the therapeutic approach of the potentially blinding disease "wet AMD" into a more favorable outcome.

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“…If an exudative change was observed on OCT, FA/ICGA was performed to confirm the MNV subtype. The presence of reticular pseudodrusen was defined as the presence of characteristic imaging by at least one imaging modality, as previously described 24 . Because this study is a multi-institutional study, the case discrimination and measurement of the retinal and choroidal structure were performed by 3 retinal specialists (Y.S, K.T, A.M) in each institute, not setting a reading center.…”

Section: Methodsmentioning

confidence: 99%

Incidence and risk of advanced age-related macular degeneration in eyes with drusenoid pigment epithelial detachment

Shijo

Sakurada

Takada

et al. 2022

Sci Rep

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To investigate the incidence and risk of advanced age-related macular degeneration (AMD), including geographic atrophy (GA) and macular neovascularization (MNV), in eyes with drusenoid pigment epithelial detachment (PED). Eighty-five eyes with drusenoid PED from 85 patients (77.2 ± 7.0 years, male/female: 44/41) were included in this study. Patients were followed up every 1–3 months via spectral-domain optical coherence tomography (SD-OCT) and color fundus photography. If exudation was observed on SD-OCT, fluorescein and indocyanine green angiography were performed to confirm the MNV subtype accordingly. The maximum follow-up period was 60 months. During the study period, GA developed in 8 eyes while MNV also developed in 8 eyes. The Kaplan–Meier estimator revealed that the cumulative incidence for 60 months was 17.9% and 12.2% for GA and MNV, respectively. In eyes developing MNV, retinal angiomatous proliferation was the most common. Cox regression analysis revealed that baseline PED width was the only factor associated with advanced AMD. (p = 0.0026, Cox regression analysis). The 5-year cumulative incidence of advanced AMD, including GA and MNV, was approximately 30% in eyes with drusenoid PED among the Japanese elderly. A larger baseline PED width was the only risk factor for advanced AMD.

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Prevalence and characteristics of pseudodrusen subtypes in advanced age-related macular degeneration

Abstract: Among eyes with advanced AMD associated with pseudodrusen, ribbon-dominant type pseudodrusen were more prevalent in eyes with GA or RAP and were associated with large soft drusen and female patients.

Cited by 14 publications

References 13 publications

Comparison of two-year outcomes after photodynamic therapy with ranibizumab or aflibercept for polypoidal choroidal vasculopathy

Comparison of two-year outcomes after photodynamic therapy with ranibizumab or aflibercept for polypoidal choroidal vasculopathy

Recent developments in age-related macular degeneration: a review

Incidence and risk of advanced age-related macular degeneration in eyes with drusenoid pigment epithelial detachment

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