Prevalence and associated risk factors of <i>Helicobacter pylori</i> infection in the Wuwei cohort of north‐western China

Zhang, Fuhua; Pu, Ke; Wu, Zhengqi; Zhang, Zhiyi; Liu, Xin; Chen, Zhaofeng; Ye, Yuwei; Wang, Yuping; Zheng, Ya; Zhang, Jinhua; An, Feng Rong; Zhao, Shuang; Hu, Xiaobin; Li, Youpeng; Li, Qiang; Lee, Min; Lü, Hong; Zhang, Hongling; Zhao, Yue; Yuan, Hao; Ding, Xuanfeng; Shu, Xiaochuang; Ren, Qian; Gou, Xi; Hu, Zenan; Wang, Jun; Wang, Yuling; Guan, Quanlin; Guo, Qinghong; Ji, Rui; Zhou, Yongning

doi:10.1111/tmi.13517

Cited by 29 publications

(39 citation statements)

References 41 publications

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“…For H. pylori- infected adult patients in the family, eradication therapy is recommended unless competing considerations exist. 1 13 Recent studies on the genotyping of infected persons also show that type I H. pylori strains (CagA and VacA positive) are the major type of H. pylori infection in Chinese residents, 65 103 104 and it induces severer inflammation, gastric mucosal lesions and are more prevalent in patients with GC than type II (CagA and VacA negative) strains. This is also supported by population-based studies and confirmed by basic science research experiments.…”

Section: Resultsmentioning

confidence: 99%

Chinese Consensus Report on Family-BasedHelicobacter pyloriInfection Control and Management (2021 Edition)

Ding

Lü

et al. 2021

Gut

103

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Objective Helicobacter pyloriinfection is mostly a family-based infectious disease. To facilitate its prevention and management, a national consensus meeting was held to review current evidence and propose strategies for population-wide and family-basedH. pyloriinfection control and management to reduce the related disease burden. Methods Fifty-seven experts from 41 major universities and institutions in 20 provinces/regions of mainland China were invited to review evidence and modify statements using Delphi process and grading of recommendations assessment, development and evaluation system. The consensus level was defined as ≥80% for agreement on the proposed statements. Results Experts discussed and modified the original 23 statements on family-basedH. pyloriinfection transmission, control and management, and reached consensus on 16 statements. The final report consists of three parts: (1)H. pyloriinfection and transmission among family members, (2) prevention and management ofH. pyloriinfection in children and elderly people within households, and (3) strategies for prevention and management ofH. pyloriinfection for family members. In addition to the ‘test-and-treat’ and ‘screen-and-treat’ strategies, this consensus also introduced a novel third ‘family-basedH. pyloriinfection control and management’ strategy to prevent its intrafamilial transmission and development of related diseases. Conclusion H. pyloriis transmissible from person to person, and among family members. A family-basedH. pyloriprevention and eradication strategy would be a suitable approach to prevent its intra-familial transmission and related diseases. The notion and practice would be beneficial not only for Chinese residents but also valuable as a reference for other highly infected areas.

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Section: Resultsmentioning

confidence: 99%

Chinese Consensus Report on Family-BasedHelicobacter pyloriInfection Control and Management (2021 Edition)

Ding

Lü

et al. 2021

Gut

103

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“…High income and higher educational levels are associated with a decrease in the prevalence of H. pylori gastritis [12,13]. Additionally, age, occupation, the type of drinking water used, consumption of fruits, vegetables, or fried food are also independent risk factors for H. pylori infection [14][15][16]. Smoking and alcohol consumption were also found to be independently positively associated factors [17].…”

Section: Introductionmentioning

confidence: 96%

Helicobacter pylori Infection: Comparison of Knowledge between Health Science and Non-Health Science University Students

Hafiz

D'Sa

Zamzam

et al. 2021

IJERPH

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Background: Helicobacter pylori (H. pylori), an important human pathogen, is classified as a human carcinogen. It is known to cause dyspepsia, peptic ulcers, and gastric cancer. Awareness regarding H. pylori infections in Saudi Arabia awaits investigation to reduce or even eliminate the infection that would ease the substantial burden of managing H. pylori among both malignant and non-malignant diseases. Aims: The study aims were to (1) assess the knowledge of H. pylori infection, testing, and management among undergraduate students in Saudi Arabia and (2) compare the H. pylori knowledge among health science and non-health science students. Methods: This study involved a cross-sectional online survey among 334 undergraduate students in health science and non-health science colleges at King Saud University, Saudi Arabia, using a valid and reliable author-developed survey. The survey had two sections: the socio-demographic factors and knowledge items regarding H. pylori. Data were collected during the 2019–2020 academic year. Data analysis included descriptive statistics, Chi-square, and Mann–Whitney U test. The knowledge scores were categorized as poor, fair, and good. Results: Less than 10% of the students in both groups had a good knowledge level about H. pylori. The comparison of the overall mean between both groups was non-significant. Moreover, the level of knowledge of the respondents was significantly associated with their university level (p < 0.001), family monthly income (p < 0.007), having heard about H. pylori infection (p < 000.1), and a previous history of H. pylori infection (p < 000.1). Conclusion: The overall knowledge level of Saudi undergraduate students about H. pylori infection was low. Thus, health awareness interventions through educational programs are recommended for improving their knowledge about H. pylori infection and its prevention.

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“…However, our results did not support this conclusion. HP virulence factors vary depending on the geographical distribution, and not all HPs can produce these virulence proteins ( 45 ). Although the dominant HP isolates are CagA gene-positive in East Asia ( 45 , 46 ), some infected individuals in our study may carry CagA gene-negative strains, and whether the negative strains affect the stability of plaques is still unclear, which may cause inaccurate results.…”

Section: Discussionmentioning

confidence: 99%

“…HP virulence factors vary depending on the geographical distribution, and not all HPs can produce these virulence proteins ( 45 ). Although the dominant HP isolates are CagA gene-positive in East Asia ( 45 , 46 ), some infected individuals in our study may carry CagA gene-negative strains, and whether the negative strains affect the stability of plaques is still unclear, which may cause inaccurate results. In addition, we speculated that the bacterial content in the plaque potentially affects plaque stability, and when the bacteria are present in small amounts, they will not affect the stability of plaques.…”

Section: Discussionmentioning

confidence: 99%

Association of Helicobacter pylori Infection With Carotid Atherosclerosis in a Northern Chinese Population: A Cross-Sectional Study

Zhang

Song

Wang

et al. 2022

Front. Cardiovasc. Med.

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Numerous studies have shown that Helicobacter pylori (HP) infection may be involved in the development of carotid atherosclerosis (CAS), but this conclusion is still controversial. The aim of this study was to explore whether there is a positive association between HP infection and CAS occurrence. We collected data on demographic characteristics, lifestyle, and disease history of the participants by questionnaire. We obtained clinical anthropometric data and blood samples of the participants from clinical examinations and laboratory work. The 13C urea breath test (13C-UBT) was performed to assess the HP infection status, and carotid ultrasonography was used to diagnose the CAS and plaque types. Univariate analysis and multivariate logistic regression were used to identify the relationship between HP infection and CAS. A total of 1,424 participants were recruited for this study. A total of 740 HP-positive individuals and 684 HP-negative individuals were identified, and 345 participants were diagnosed with CAS. The prevalence of CAS was higher in the HP-positive group (26.4%) than in the HP-negative group (21.7%) (P < 0.05). A significantly higher prevalence of carotid intima-media thickening, carotid plaque, and carotid stenosis was identified in the HP-positive group than in the HP-negative group (P < 0.05). There was no significant difference in the detection rate of unstable plaques between the HP-positive and HP-negative groups (P > 0.05). In multivariate models adjusted for covariates, HP infection showed a positive association with CAS, independent of other risk factors (ORs range: 1.283–1.333, P < 0.05). HP infection independently accounted for approximately 5% of the CAS risk in the absence of other cardiovascular risk factors. A positive association between HP infection and CAS was demonstrated in this study. HP infection might be an independent risk factor for CAS. Although the effect of HP infection on CAS observed in our study was less than that of traditional risk factors, we believe that this is an indispensable advance in the etiological study of CAS. These results imply that the microbial population might play an essential role in CAS, which provides a new perspective for the primary prevention of CAS.

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Prevalence and associated risk factors of Helicobacter pylori infection in the Wuwei cohort of north‐western China

Cited by 29 publications

References 41 publications

Chinese Consensus Report on Family-BasedHelicobacter pyloriInfection Control and Management (2021 Edition)

Chinese Consensus Report on Family-BasedHelicobacter pyloriInfection Control and Management (2021 Edition)

Helicobacter pylori Infection: Comparison of Knowledge between Health Science and Non-Health Science University Students

Association of Helicobacter pylori Infection With Carotid Atherosclerosis in a Northern Chinese Population: A Cross-Sectional Study

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