Chinese Consensus Report on Family-BasedHelicobacter pyloriInfection Control and Management (2021 Edition)

Abstract

Objective Helicobacter pyloriinfection is mostly a family-based infectious disease. To facilitate its prevention and management, a national consensus meeting was held to review current evidence and propose strategies for population-wide and family-basedH. pyloriinfection control and management to reduce the related disease burden. Methods Fifty-seven experts from 41 major universities and institutions in 20 provinces/regions of mainland China were invited to review evidence and modify statements using Delphi process and grading of recommendations assessment, development and evaluation system. The consensus level was defined as ≥80% for agreement on the proposed statements. Results Experts discussed and modified the original 23 statements on family-basedH. pyloriinfection transmission, control and management, and reached consensus on 16 statements. The final report consists of three parts: (1)H. pyloriinfection and transmission among family members, (2) prevention and management ofH. pyloriinfection in children and elderly people within households, and (3) strategies for prevention and management ofH. pyloriinfection for family members. In addition to the ‘test-and-treat’ and ‘screen-and-treat’ strategies, this consensus also introduced a novel third ‘family-basedH. pyloriinfection control and management’ strategy to prevent its intrafamilial transmission and development of related diseases. Conclusion H. pyloriis transmissible from person to person, and among family members. A family-basedH. pyloriprevention and eradication strategy would be a suitable approach to prevent its intra-familial transmission and related diseases. The notion and practice would be beneficial not only for Chinese residents but also valuable as a reference for other highly infected areas.

Probiotics modulate gastrointestinal microbiota after Helicobacter pylori eradication: A multicenter randomized double-blind placebo-controlled trial

“…The infection of H. pylori is associated with a variety of diseases, including gastritis, peptic ulcers and gastric cancer. Therefore, a subsequent of global consensus has recommended eradication therapy, unless there are competing considerations ( 1 , 20 , 21 ). With the prevalence of antibiotic resistance worldwide, the first-line regimen transformed from triple to quadruple therapy and the duration was prolonged from 7 days to 14 days, causing increased side effects and poor compliance.…”

The management of Helicobacter pylori infection and prevention and control of gastric cancer in China

“…Additionally, a recent systematic review and meta-analysis provided the sufficient evidences that whole family-based H. pylori treatment could increase eradication rate and reduce recurrence rate compared with single-infected patient treatment approach ( Zhao et al., 2021 ). A family-based H. pylori prevention and eradication strategy would be an effective approach to prevent its intra-familial transmission ( Ding et al., 2022 ).…”

“…Additionally, in an analysis of data from a public hospital database with 73, 237 H. pylori positive subjects included on Hong Kong, H. pylori infection eradication reduced the risk of GC in subjects 60 years or older compared to the matched general population ( Leung et al., 2018 ). As such, the Chinese consensus ( Du et al., 2020 ; Ding et al., 2022 ) have emphasized the importance of early detection, diagnosis, and treatment of H. pylori to reduce the occurrence of GC and a family-based H. pylori prevention and eradication strategy to prevent its intra-familial transmission and related diseases. Additionally, national, provincial and regional specialist clinic of H. pylori infection was established by the office of H. pylori infection and GC prevention and control, which could promote the standard of H. pylori diagnosis and treatment.…”

Characteristics and background mucosa status of early gastric cancer after Helicobacter pylori eradication: A narrative review

“…[6–11] Thus, on reports, H pylori eradication has shifted from treatment to primary prevention of gastric cancer on reports. [10–13]…”

“…[6][7][8][9][10][11] Thus, on reports, H pylori eradication has shifted from treatment to primary prevention of gastric cancer on reports. [10][11][12][13] However, the risk of progression to gastric cancer still exists after successful H pylori eradication. Gastric cancer after H pylori eradication is defined as early gastric cancer detected after more than 1 year of successful H pylori eradication, which contains primary gastric cancer and metachronous gastric cancer.…”