Prevalence and antimicrobial susceptibility profle of ESKAPE pathogens from the
            Federal District, Brazil

Silva, Daniely M.; Menezes, Eulina Maria N.; Silva, Emerson V.; Lamounier, Thaís Alves da Costa

doi:10.5935/1676-2444.20170037

Cited by 6 publications

(5 citation statements)

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“…Instead, S. aureus represented 22.0%, Enterobacter spp. 11.0%, A. baumannii 8.0% and E. faecium 4.0% ( Silva et al., 2017 ). These results are similar to those detected in Hermosillo and Ciudad Obregón, but quite different from a Romanian study, where S. aureus was the microorganism isolated in the highest proportion with 62.4%, followed by K. pneumoniae with 16.6%, P. aeruginosa with 13.1%, Enterobacter spp.…”

Section: Discussionmentioning

confidence: 99%

“…None of the resistance percentages obtained exceeds what is mentioned in the literature. A study carried out in Brazil found high percentages of resistance to vancomycin (79.2%), ampicillin (91.7%), ciprofloxacin (91.7%) and linezolid (8.3%) ( Silva et al., 2017 ). Table 2 shows a remarkably high value for resistance to tetracycline, a result opposite to that found by Silva and colleagues (2017) where most of the resistance values are excessively high, except for tetracycline (37.5%) ( Llaca-Díaz et al., 2013 ).…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic resistance of ESKAPE group-microorganisms in health institutions from Hermosillo and Ciudad Obregón, Sonora, México

Álvarez-Ainza,

Fong-Coronado,

Ruiz-Bustos

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionEnterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. are microorganisms referred as the ESKAPE group pathogens. These microorganisms have generated great concern in health institutions around the world since most of them have resistance to multiple antibiotics and cause most infections associated with healthcare, as well as community infections. The aim of this study was the analysis of antibiotic resistance in microorganisms of the ESKAPE group, recovered from clinical samples in 11 health institutions from Hermosillo and Ciudad Obregón in the State of Sonora, México, during the period from 2019 to 2020.MethodsA cross-sectional, descriptive, observational, and temporality epidemiological study was carried out. A comparative and statistical analysis of antibiotic resistance was carried out using the chi-square test, and small values were analyzed using Fisher’s exact test p ≤ 0.05.Results and discussionAll the ESKAPE group microorganisms showed significant differences in antibiotic resistance percentages between both cities. High resistance percentages for some antibiotics, like cephalosporins and ciprofloxacin were detected for Klebsiella pneumoniae and Acinetobacter baumannii.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antibiotic resistance of ESKAPE group-microorganisms in health institutions from Hermosillo and Ciudad Obregón, Sonora, México

Álvarez-Ainza,

Fong-Coronado,

Ruiz-Bustos

et al. 2024

Front. Cell. Infect. Microbiol.

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“…However, 13.5% of MRSA isolates in the present study were characterized as non-susceptible to daptomycin. Although daptomycin resistance among S. aureus remains rare worldwide (< 0.1%) [ 1 ], Silva et al [ 46 ] also found isolates non-susceptible to daptomycin (4.7%) in a Brazilian study involving 128 clinical S. aureus isolates. We have already described BSI caused by non-susceptible daptomycin S. aureus isolates (MIC of 2 and 4 mg/L) among MRSA-VISA isolates in the hospital of the present study [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Pandemic clone USA300 in a Brazilian hospital: detection of an emergent lineage among methicillin-resistant Staphylococcus aureus isolates from bloodstream infections

Augusto

Fernandes

Oliveira

et al. 2022

Antimicrob Resist Infect Control

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Background Staphylococcus aureus is one of the leading causes of bloodstream infections (BSI) worldwide. In Brazil, the hospital-acquired methicillin-resistant S. aureus USA100/SCCmecII lineage replaced the previously well-established clones. However, the emergence of community-associated (CA) MRSA lineages among hospitalized patients is an increasing issue. Methods Consecutive S. aureus isolates recovered from BSI episodes of patients admitted between January 2016 and December 2018 in a Brazilian teaching hospital were tested for antimicrobial resistance, their genotypic features were characterized, and the clinical characteristics of the patients were evaluated. Results A total of 123 S. aureus isolates were recovered from 113 patients. All isolates were susceptible to linezolid, teicoplanin and vancomycin and 13.8% were not susceptible to daptomycin. Vancomycin MIC50 and MIC90 of 2 mg/L were found for both MRSA and MSSA isolates. The MRSA isolation rate was 30.1% (37/123), and 51.4% of them carried the SCCmec type II, followed by SCCmecIV (40.5%). Among the 37 MRSA isolates, the main lineages found were USA100/SCCmecII/ST5 and ST105 (53.7%) and USA800/ST5/SCCmecIV (18.9%). Surprisingly, six (16%) CA-MRSA isolates, belonging to USA300/ST8/SCCmecIVa that carried PVL genes and the ACME cassette type I, were detected. These six patients with USA300 BSI had severe comorbidities, including cancer, and most had a Charlson score ≥ 5; furthermore, they were in wards attended by the same health professionals. MRSA isolates were associated with hospital acquired infections (p = 0.02) in more elderly patients (p = 0.03) and those diagnosed with hematologic cancer (p = 0.04). Among patients diagnosed with MRSA BSI, 19 (54.3%) died. Conclusions The pandemic MRSA USA300 was detected for the first time in the Brazilian teaching hospital under study, and its cross-transmission most probably occurred between patients with BSI. This lineage may already be circulating among other Brazilian hospitals, which highlights the importance of carrying out surveillance programs to fight multidrug resistant and hypervirulent isolates.

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“…Contudo, o fato da maioria das bactérias detectadas nessa pesquisa pertencerem ao grupo ESKAPE, que são bactérias frequentemente relacionadas a infecções adquiridas em hospitais, capazes de driblar as ações antimicrobianas devido aos mecanismos de resistência, reporta a urgência da implementação das boas práticas assistenciais. Essas bactérias estão relacionadas a altos índices de morbimortalidade e dificuldades no manejo terapêutico, tornando-se um problema grave em diversos países, inclusive no Brasil 2,26 .…”

Section: Issn 2236-5834unclassified

Ocorrência de contaminações por bactérias multirresistentes em leitos hospitalares na Amazônia durante a pandemia de COVID-19

et al. 2021

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RESUMO: Objetivos: Determinar o fenótipo de susceptibilidade frente aos antimicrobianos de bactérias isoladas antes e depois da desinfecção de leitos em dois hospitais no Sudeste do Pará. Métodos: Estudo do tipo descritivo, realizado em dois hospitais no Sudeste do Estado do Pará, um de baixa e média complexidade- hospital A (HA) e outro média e alta complexidade- hospital B (HB). A identificação quanto ao gênero e espécie seguiram as recomendações da ANVISA e para determinação do perfil de susceptibilidade frente aos antimicrobianos as recomendações do BrCAST. Resultados: Das superfícies avaliadas 62,5% (50/80) apresentaram positividade. Dessas verificou-se maior frequência no hospital A 67,5% (27/40). Quanto ao perfil de susceptibilidade das bactérias gram-negativas, observou-se que os isolados nos leitos do hospital A e B apresentaram elevada resistência às cefalosporinas e penicilinas, podendo chegar a 100%. Observou-se também que 54,0% (27/50) das cepas isoladas nos dois hospitais multirresistentes. Considerações finais: A resistência bacteriana é um problema emergente de saúde pública que exige esforço para a sua mitigação e foi detectada de forma significativa nos dois hospitais. Portanto, é imprescindível a triagem de leitos para contaminação por cepas MDRs, além da adoção das boas práticas para controle, como a compilação de higiene ambiental, das mãos e culturas de vigilância.

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Prevalence and antimicrobial susceptibility profle of ESKAPE pathogens from the Federal District, Brazil

Cited by 6 publications

References 0 publications

Antibiotic resistance of ESKAPE group-microorganisms in health institutions from Hermosillo and Ciudad Obregón, Sonora, México

Antibiotic resistance of ESKAPE group-microorganisms in health institutions from Hermosillo and Ciudad Obregón, Sonora, México

Pandemic clone USA300 in a Brazilian hospital: detection of an emergent lineage among methicillin-resistant Staphylococcus aureus isolates from bloodstream infections

Ocorrência de contaminações por bactérias multirresistentes em leitos hospitalares na Amazônia durante a pandemia de COVID-19

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