Prevalence and antimicrobial susceptibility pattern of Coagulase-negative Staphylococcus

Begum, E. Shamsadh; Anbumani, N; Kalyani, J; Mallika, M

doi:10.5530/ijmedph.4.2011.14

Cited by 13 publications

(20 citation statements)

References 15 publications

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“…In the present study, S. epidermidis (53.8%) was the most clinically significant of the CoNS species and S. haemolyticus (40.7%) was identified as the second, which is in agreement with other reports [20][21][22]. The rate of the CoNS isolation was highest in blood (43%) followed by urine (36.3%), catheter (14.3%) and wound samples (6.6%).…”

Section: Discussionsupporting

confidence: 91%

Identification of hemolysin encoding genes and their association with antimicrobial resistance pattern among clinical isolates of coagulase-negative Staphylococci

et al. 2020

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Objective: Coagulase-negative staphylococci (CoNS) are as considered opportunistic pathogens which capable of producing several toxins, enzymes and resistance genes. The current study aimed to determine the occurrence of different hemolysins genes and patterns of antibiotic resistance among CoNS species. Results:The highest frequency of antibiotic resistance was observed against cefoxitin in 49 isolates (53.8%), and the lowest resistance was against novobiocin in 5 isolates (5.5%). None of the isolates was resistant to vancomycin. The prevalence of hla, hla_yidD, hld, and hlb genes was: 87.9%, 62.6%, 56%, and 47.3%, respectively. The hla/yidD and hld genes were detected in 69.4% of S. epidermidis and the hla gene in 94.6% of S. haemolyticus isolates; the hlb gene was detected in 53.1% of the S. epidermidis isolates. The mecA gene was identified in 50 (55%) of the CoNS isolates. In conclusion, the results of statistical analysis showed that the hld gene had a significant association with resistance to levofloxacin and erythromycin antibiotics, the hlb with clindamycin resistance and the hla/yidD with rifampicin and novobiocin resistance. The results of this study showed that there is a significant relationship between hemolysin encoding genes and antibiotic resistance patterns; therefore, detection of virulence factors associated with antibiotic resistance has become a significant issue of concern.

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Section: Discussionsupporting

confidence: 91%

Identification of hemolysin encoding genes and their association with antimicrobial resistance pattern among clinical isolates of coagulase-negative Staphylococci

et al. 2020

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“…Among various species of Coagulase negative staphylococcus, S.hemolyticus was found to be more multidrug resistant than S.epidermidis. Similar results were obtained by Begum et al, (2011) andMa xx et al, (2011).…”

Section: Multidrug Resistant Conssupporting

confidence: 80%

“…Teicoplanin resistance was seen in 6.3% of the study isolates in the present study.In a study from China comparing the antibiotic resistance pattern of CoNS over a period of 2004 to 2009, there was an increase in the teicoplanin resistance from no resistance noted till 2007 and 6.7% resistance in 2009. Teicoplanin resistance of 2.7% was observed in Begum et al, (2011) study. As for vancomycin universal sensitivity was notedin our study.…”

Section: Multidrug Resistance In Consmentioning

confidence: 82%

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Speciation and Antibiotic Susceptibility Testing of Coagulase Negative Staphylococci at a Tertiary Care Teaching Hospital

Alex¹,

Mahesh²,

Navaneeth³

2017

Int.J.Curr.Microbiol.App.Sci

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“…Gentamicin is a most commonly used drug, because of its low cost and synergistic activity with beta-lactam antibiotics. In the present study, 94% of gentamicin resistance was seen, which was slightly higher than a previous study 30 . Most common reason for multidrug resistant MRSA is indiscriminate use of antibiotics without drug sensitivity testing which may be due to lack of advanced laboratory facilities or negligence on the part of medical practitioners or patients poor economic status.…”

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confidence: 45%

Prevalence of Methicillin Resistant Staphylococcus Aureus (Mrsa) and Antimicrobial Susceptibility Patterns at a Private Hospital in Sana'a, Yemen

Alyahawi

Al-kaf

Alhomidi

2018

UJPR

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Methicillin resistant Staphylococcus aureus (MRSA) strains are common causes of nosocomial infections and are associated with increased morbidity and mortality. In addition, the antibiotic resistance for MRSA is a major concern in clinical practice. To study the prevalence and the antimicrobial susceptibility pattern of MRSA isolates from patients in a private hospital. The study was performed at a private hospital in Sana'a, Yemen. All the patients' samples from January, 2017 to December, 2017 were included. All isolates from inpatients' clinical specimens (mainly respiratory secretion, pus, urine, and blood) were collected and standard isolation procedures were applied to all the samples. The records were taken from the microbiology department. Antibiotic susceptibility testing was done by Kirby Bauer's Disc diffusion technique, following the national committee for clinical laboratory standards. The antimicrobial susceptibility patterns of all the MRSA strains were studied against several antibiotics. A total of 2079 samples were gathered during the study period. Among them, 199 strains of Staphylococcus aureus were isolated. A majority of Staphylococcus aureus isolates were from pus specimen (n=81/199; 40.7%). MRSA prevalence among the patients was 17.6 % (n=35/199; 17.6). Highest proportion of MRSA was in ICU and surgical departments about 29% of all MRSA isolates. A majority of MRSA isolates were from sputum specimen (n=18/35; 51.4%). The study findings showed that MRSA isolates had the highest frequency of resistant (100%) to levofloxacin and amoxicillin/ clavulinic acid, followed by ciprofloxacin 97%, gentamicin and ampicillin/ sulbactam 94 %, cefuroxime 91 %, moxifloxacin 76%, erythromycin 71.5%, clindamycin 70.5%, and imipenem 55%. The highest frequency of sensitivity (100%) was observed with linezolide, vancomycin, and trimethoprim/ sulfamethoxazole. MRSA isolates were highly susceptible to newer drugs such as linezolid and to vancomycin which is not a commonly prescribed drug due to the higher nephrotoxic antibiotic. A more careful monitoring for use of broad-spectrum antibiotics should be instituted.

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Prevalence and antimicrobial susceptibility pattern of Coagulase-negative Staphylococcus

Cited by 13 publications

References 15 publications

Identification of hemolysin encoding genes and their association with antimicrobial resistance pattern among clinical isolates of coagulase-negative Staphylococci

Identification of hemolysin encoding genes and their association with antimicrobial resistance pattern among clinical isolates of coagulase-negative Staphylococci

Speciation and Antibiotic Susceptibility Testing of Coagulase Negative Staphylococci at a Tertiary Care Teaching Hospital

Prevalence of Methicillin Resistant Staphylococcus Aureus (Mrsa) and Antimicrobial Susceptibility Patterns at a Private Hospital in Sana'a, Yemen

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