Preussomerin D from the Endophyte Hormonema dematioides

Polishook, Jon D.; Dombrowski, Anne W.; Tsou, Nancy N.; Salituro, Gino; Curotto, James E.

doi:10.2307/3760478

Cited by 23 publications

(17 citation statements)

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“…This is the first report on the occurrence of preussomerins from this genus. All previous isolations of this unusual class of compounds were from coprophilous (dung-colonized) fungi of the family Sporormiaceae except for a report on the isolation of preussomerin D from an endophytic fungus Hormonema dematioides [5].…”

Section: Resultsmentioning

confidence: 99%

“…Preussomerins belong to a class of fungal metabolites previously isolated from dung-colonizing fungi Preussia isomera [1], [2], Sporormiella vexans [3], an unidentified coelomycetes (MF 5916) [4], and from an endophytic fungus Harmonema dematioides [5]. All together 10 isomers, preussomerins A-I and 3¢-O-demethyl-1epipreussomerin C, have been reported.…”

Section: Introductionmentioning

confidence: 99%

“…A crude extract of the strain BCC 3050 showed antimycobacterial and antiplasmodial activity. Bioassay guided fractionation led to the isolation of five known preussomerins E (1), F (2), G (3), H (4) and I (5) to-gether with a new derivative, 3'-O-demethylpreussomerin I (6). Two deoxypreussomerins, deoxypreussomerin A (7) and bipendensin (palmarumycin C 11 ) (8), were also isolated from the same culture broth.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Antimycobacterial, Antiplasmodial and Cytotoxic Activities of Preussomerins Isolated from the Lichenicolous Fungus Microsphaeropsis sp. BCC 3050

Seephonkai

Isaka²,

Kittakoop³

et al. 2002

Planta med

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A new preussomerin isomer, 3'-O-demethylpreussomerin I, five known preussomerins E - I, and two known deoxypreussomerins, deoxypreussomerin A and bipendensin (palmarumycin C11), were isolated from a lichenicolous fungus Microsphaeropsis sp. BCC 3050. These structures were elucidated by spectroscopic methods, especially 1D- and 2D-NMR. The preussomerins were evaluated for their antimycobacterial and antiplasmodial activities as well as cytotoxicity against KB, BC-1 and vero cell lines.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Antimycobacterial, Antiplasmodial and Cytotoxic Activities of Preussomerins Isolated from the Lichenicolous Fungus Microsphaeropsis sp. BCC 3050

Seephonkai

Isaka²,

Kittakoop³

et al. 2002

Planta med

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“…Some regions of the sky, known as the "high-cadence" regions in PTF, have been observed more than 100 times. One such region on which we focus in this paper is a 45 deg 2 field roughly centered on the Praesepe 4 cluster (08 h 40 ′ 24 ′′ , +19 • 41 ′ ), which has been imaged more than 200 times by PTF in the R-band (Agüeros et al 2011;Polishook et al 2012). Relative to other, less observed areas, the Praesepe region is interesting because, due to chance and a large number of observations, it has a non-negligible number of images that are deeper than the nominal 5σ faint limit at R = 20.6 (i.e., images that were taken in better than average conditions).…”

Section: Overview Of the Palomar Transient Factory Surveymentioning

confidence: 99%

Two Distant Halo Velocity Groups Discovered by the Palomar Transient Factory

Sesar

Cohen

Levitan

et al. 2012

ApJ

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We report the discovery of two new halo velocity groups (Cancer groups A and B) traced by 8 distant RR Lyrae stars and observed by the Palomar Transient Factory (PTF) survey at R.A ∼ 129 • , Dec ∼ 20 • (l ∼ 205 • , b ∼ 32 • ). Located at 92 kpc from the Galactic center (86 kpc from the Sun), these are some of the most distant substructures in the Galactic halo known to date. Follow-up spectroscopic observations with the Palomar Observatory 5.1-m Hale telescope and W. M. Keck Observatory 10-m Keck I telescope indicate that the two groups are moving away from the Galaxy atv A gsr = 78.0 ± 5.6 km s −1 (Cancer group A) andv B gsr = 16.3 ± 7.1 km s −1 (Cancer group B). The groups have velocity dispersions of σ A vgsr = 12.4 ± 5.0 km s −1 and σ B vgsr = 14.9 ± 6.2 km s −1 , and are spatially extended (about several kpc) making it very unlikely that they are bound systems, and are more likely to be debris of tidally disrupted dwarf galaxies or globular clusters. Both groups are metal-poor (median metallicities of [Fe/H] A = −1.6 dex and [Fe/H] B = −2.1 dex), and have a somewhat uncertain (due to small sample size) metallicity dispersion of ∼ 0.4 dex, suggesting dwarf galaxies as progenitors. Two additional RR Lyrae stars with velocities consistent with those of the Cancer groups have been observed ∼ 25 • east, suggesting possible extension of the groups in that direction.

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“…Zink et al 39 studied the structure-activity relationships of preussomerin G (101), H (102), I (103), D (104), deoxypreussomerin A (105) and B (106) extracted from the coprophilous fungus Preussia isomera, and the endophytic fungus Harmonema dematioides [123][124][125] which are fungal metabolites. They have a certain inhibitory activity on FTase.…”

Section: Preussia Sp and Harmonema Dematioidesmentioning

confidence: 99%

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

Dai

Sun

Zhang

et al. 2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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As one of the world's five terminally ills, tumours can cause important genetic dysfunction. However, some current medicines for tumours usually have strong toxic side effects and are prone to drug resistance. Studies have found that farnesyltransferase inhibitors (FTIs) extracted from natural materials have a good inhibiting ability on tumours with fewer side effects. This article describes several FTIs extracted from natural materials and clarifies the current research progress, which provides a new choice for the treatment of tumours.

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Preussomerin D from the Endophyte Hormonema dematioides

Cited by 23 publications

References 0 publications

Evaluation of Antimycobacterial, Antiplasmodial and Cytotoxic Activities of Preussomerins Isolated from the Lichenicolous Fungus Microsphaeropsis sp. BCC 3050

Evaluation of Antimycobacterial, Antiplasmodial and Cytotoxic Activities of Preussomerins Isolated from the Lichenicolous Fungus Microsphaeropsis sp. BCC 3050

Two Distant Halo Velocity Groups Discovered by the Palomar Transient Factory

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

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