Pretreatment of Tribulus terrestris L. causes anti-ischemic cardioprotection through MAPK mediated anti-apoptotic pathway in rat

Effect of Eight Weeks of Resistance Training and Consumption of Tribulus Terrestris on Androgenic Receptor-1, Fas Ligand Gene Expression, and Lipid Profiles in Rats Exposed to Stanozolol

“…Furthermore, the consumption of 120 mg/kg of TT for 8 weeks had a significant effect on AR-1 in rats (32). Additionally, TT consumption at different doses for 8 weeks improved the signaling pathways of p38αMAPK, JNK, and Akt, decreased Bax and Bad and increased Bcl-2 in cardiac tissue in vivo and in vitro (12). The use of Figure 1.…”

“…The researchers found that 85 and 50 mg/kg of hydroalcoholic extract of TT significantly improved lipid profile in rats with coronary heart disease induced by injecting isoproterenol (13). Moreover, 0.3, 7.1, and 8.7 µg/mL of TT significantly reduced TNFL and FasL levels in the cell and induced apoptosis in cancer cells (12). However, studies have shown that athletes also use the estrogenic effects of this herb, as Pokrywka et al showed that dose-dependent consumption of TT in athletes improved athletic performance and increased strength (14,15).…”

“…Given that the use of medicinal plants has long been considered in the treatment and prevention of many diseases in recent years, the number of studies on the effect of medicinal plants as an alternative to synthetic drugs has increased. Among medicinal plants, Tribulus terrestris L. (TT) which belongs to annual plants from the Zygophyllaceae family is rich in flavonoids, alkaloids, saponins, legins, amides, and glycosides, and its protective effects on the heart and arteries have been proven (12).…”

Hepatotoxicity-Induced by the Therapeutic Dose of Acetaminophen and the Ameliorative Effect of Oral Co-administration of Selenium/Tribulus terrestris Extract in Rats

“…The extract was concentrated in a ventilated oven at 45 ºC for 24 h. Dried powder of 45 g yielded an extract of about 10 g, which was dark brown in color. The characteristics and bioactive constituents of TT were assessed previously by Reshma et al (2019) in the plant list website (www.theplantlist.org). Experimental design: A total of 54 healthy adult male albino rats (Rattus norvegicus) were randomly divided into nine groups (n=6 rats each) their dosing and route of administration provided in (Table I).…”

Tribulus terrestris Ameliorates Oxidative Stress-Induced ARPE-19 Cell Injury through the PI3K/Akt-Nrf2 Signaling Pathway

“…Modern studies have shown that TT has various pharmacological effects including anti-inflammatory, antioxidant, antibacterial, antiaging, and antitumor activities [ 21 , 22 ]. TT has been used in clinical therapy, especially for the prevention and treatment of cardiovascular diseases, eye diseases, improving male sexual function, and diabetes [ 23 – 25 ]. The chemical constituents of the fruit of TT mainly include saponins, flavonoids, and alkaloids (polysaccharides, amino acids, and vitamins); the studies have shown that saponins and flavonoids in TT mainly contribute to its pharmacological activities.…”