Pretreatment of Renal Allograft Recipients With Immunosuppression and Donor-Specific Blood

Differential Suppression Activity Induced by Paternal Leukocyte Immunization in Habitual Abortion

“…It is not unlikely that alloimmunization may preferentially recruit suppressor CD8+ cells to the peripheral blood. Our findings and experimental system are analogous to the effect induced by blood transfusions in kidney-transplanted patients [29][30][31][32][33][34][35][36], Recent findings have associated CD8 lymphocytes with the acquisition of this tolerance [37]. The possibility of white cell immuni zation-inducing suppressor cells in habitual aborters is supported by a recent report with similar findings [38] 0.5-1 x 106 lymphocytes were incubated with mouse antihuman monoclonal antibodies to T4 (CD4) or T8 (CD8) and counterstained with rabbit antibodies to mouse Fc fragment.…”

Anti-Class II Antibody Production Prolongs Renal Allograft Survival

“…Terasaki [34] has suggested that the beneficial effect of transfusions on allograft survival can be attained only in conjunction with immunosuppressive therapy. Anderson et al [13] concluded that donor-specific transfusions with or without Imuran® im proved allograft survival with the former de veloping minimal sensitization. Abouna et al [2] postulated that immunization by the intravenous route with whole-blood transfu sions in mongrel dogs probably modified the antigen in some manner to produce a block ing effect on cell-mediated immunity or a stimulation of suppressor T cells.…”

“…It is widely accepted that conditioning of recipients by blood transfusions exerts a fa vorable influence on the survival of renal allotransplants [1][2][3][4][5][6][7], In the past, some in vestigators suggested that the beneficial ef fect of transfusions was only the result of selection, and many patients were thought to be rendered nontransplantable as a conse quence of sensitization by transfusions [8][9][10][11][12], A low rate of rejection in some studies does not support a selecting out process as the mechanism for improved allograft sur vival and argues for a modification of the immunologic responses [13], The effects of blood transfusions are found to improve the outcome, especially in the best HLAmatched groups [5], In contrast, others de scribed a highly significant allograft survival in the transfused DR-mismatched cadaveric kidney allograft recipients [14], Many au thors have suggested that H LA-DR antigen matching alone improves allograft survival [15][16][17][18][19][20], However, this finding is not univer sal [21]. The timing of transfusions as well as the number of units of blood needed for opti mum graft survival are still unresolved.…”

Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients

“…To reduce the risk of preoperative infusion of M regs sensitizing recipients, infusions were given under cover of 2 mg/kg/d azathioprine, commencing 3 d prior to administration of M regs and continuing for 8 wk postoperatively (9). M regs were administered 6 (MM) or 7 (CA) d prior to transplantation by central venous infusion.…”