Pretreatment of Donors with Endothelin Receptor Antagonist TAK-044 Improves Cardiac Functional Recovery Following Preservation with University of Wisconsin Solution

Kaneda, Tomoya; Zhang, Zhiwei; Ogawa, Tatsuya; Otaki, M; Sakurai, Toshihiko

doi:10.1080/140174302753675393

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Recent Reports By Zhao Et Al 27 and Frank Et Al1

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2007

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“…Research by Kaneda et al 29 and Fukunaga et al 30 established that pre-treatment of in vivo donor models with an endothelin receptor antagonist drug, TAK-044, improved cardiac functional recovery and post-operative function in hepatic allografts, respectively. In the current study we found that, not only are alveolar macrophages increased in BSD, when using a semiquantitative immunocytochemistry method, expression levels of ET-1, ET A R and ET B R in these chronic inflammatory cells are also significantly increased in this model compared with control animals.…”

Section: Recent Reports By Zhao Et Al 27 and Frank Et Almentioning

confidence: 98%