Preterm neuroimaging and neurodevelopmental outcome: a focus on intraventricular hemorrhage, post-hemorrhagic hydrocephalus, and associated brain injury

Dorner, Rebecca A.; Burton, Vera Joanna; Allen, Marilee C; Robinson, Shenandoah; Soares, Bruno P.

doi:10.1038/s41372-018-0209-5

Cited by 83 publications

(60 citation statements)

References 105 publications

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“…Brain imaging is essential in neonatal neuropediatric diagnostics [1]. In neonates, magnetic resonance imaging (MRI) serves as a reliable modality for the detection of brain pathologies, as well as for the assessment of myelination [2][3][4][5][6]. Based on conventional MRI findings, substantial information about the future course of neurodevelopment can be obtained [2,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…In neonates, magnetic resonance imaging (MRI) serves as a reliable modality for the detection of brain pathologies, as well as for the assessment of myelination [2][3][4][5][6]. Based on conventional MRI findings, substantial information about the future course of neurodevelopment can be obtained [2,[7][8][9]. Apart from deficient myelination, brain injury, e.g., due to hemorrhage, asphyxia, or infarction during the prenatal and neonatal period, may severely impair brain maturation [6,8,[10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…As described in the literature, various types of brain damage that can occur in the neonatal period may severely affect further neurodevelopment [2,[31][32][33][34]. There is evidence that hemorrhage, hypoxic ischemic encephalopathy, and infarction are primarily among the most common causes of neonatal morbidity and mortality [35,36].…”

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confidence: 99%

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Validity of SyMRI for Assessment of the Neonatal Brain

et al. 2020

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Purpose The purpose of this study was to assess the diagnostic accuracy of T1-weighted and T2-weighted contrasts generated by the MR data postprocessing software SyMRI (Synthetic MR AB, Linköping, Sweden) for neonatal brain imaging. Methods In this study 36 cases of neonatal MRI were retrospectively collected, which included T1-weighted and T2-weighted sequences as well as multi-dynamic multi-echo (MDME) sequences. Of the 36 neonates 32 were included in this study and 4 neuroradiologists independently assessed neonatal brain examinations on the basis of conventional and SyMRI-generated T1-weighted and T2-weighted contrasts, in order to determine the presence or absence of lesions. The sensitivity and specificity of both methods were calculated and compared. Results Compared to conventionally acquired T1 and T2-weighted images, SyMRI-generated contrasts showed a lower sensitivity but a higher specificity (SyMRI sensitivity 0.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Validity of SyMRI for Assessment of the Neonatal Brain

et al. 2020

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“…Ventricular dilation is a frequent phenomenon in patients with TBI and can present in follow-up examinations and develop into post-traumatic hydrocephalus (PTH) (44). Various studies have indicated that SAH and intraventricular haemorrhage (IVH) may be associated with hydrocephalus development following TBI, which can result in acute ventricular dilation at 24 h following TBI (45,46). As a result of the tearing of subependymal veins that line ventricular cavities, IVH has been associated with severe injuries (47).…”

Section: Discussionmentioning

confidence: 99%

Effects of altitude changes on mild‑to‑moderate closed‑head injury in rats following acute high‑altitude exposure

et al. 2018

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Mild-to-moderate closed-head injury (mmCHI) is an acute disease induced by high-altitudes. It is general practice to transfer patients to lower altitudes for treatment, but the pathophysiological changes at different altitudes following mmCHI remain unknown. The present study simulated acute high-altitude exposure (6,000 m above sea level) in rats to establish a model of mmCHI and recorded their vital signs. The rats were then randomly assigned into different altitude exposure groups (6,000, 4,500 and 3,000 m) and neurological severity score (NSS), body weight (BW), brain magnetic resonance imaging (MRI), brain water content (BWC) and the ratio of BW/BWC at 6, 12 and 24 h following mmCHI, and the glial fibrillary acidic protein levels were analysed in all groups. The results revealed that within the first 24 h following acute high-altitude exposure, mmCHI induced dehydration, brain oedema and neuronal damage. Brain injury in rats was significantly reversed following descent to 4,500 m compared with the results from 6,000 or 3,000 m. The results indicated that subjects should be transported as early as possible. Furthermore, avoiding large-span descent altitude was beneficial to reduce neurological impairment. The examination of brain-specific biomarkers and MRI may further be useful in determining the prognosis of high-altitude mmCHI. These results may provide guidance for rescuing high altitude injuries.

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“…The diagnostic criteria of pregnancy, perinatal and neonatal co-morbidities and complications are presented in additional le 1 [23][24][25][26][27][28][29][30][31][32][33][34]. De nitions regarding vital statistics are based on the original survey [11,20], and the 10 th revision of the international classi cation of diseases [35].…”

Section: De Nitions Of Preterm Morbidity and Mortalitymentioning

confidence: 99%

Preterm Morbidity and Mortality by Gestational Age. A Birth Population-Based Study

Sun

Guo

et al. 2020

Preprint

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Background: Despite 15-17 million of annual births in China, there is a paucity of information on preterm morbidity and mortality. We characterized the outcome of preterm births and hospitalized preterm infants by gestational age (GA) in Huai’an in 2015, an emerging prefectural region of China.Methods: Of 59,245 regional total births, clinical data on 2,651 preterm births and 1,941 hospitalized preterm neonates were extracted from Huai’an Women and Children’s Hospital (HWCH) and non-HWCH hospitals in 2018-2020. Preterm morbidity and mortality rates were characterized and compared by hospital categories and GA spectra. Death risks of preterm births and hospitalized preterm infants in the whole region were analyzed with multivariable logistic regression.Results: The incidences of extreme, very, moderate, late and total preterm of the regional total births were 1.4, 5.3, 7.2, 30.8 and 44.7‰, with all-death rates being 1.0, 1.6, 0.6, 1.1 and 4.3‰, respectively, of the regional total births. There were 1,025 (52.8% of whole region) preterm admissions in HWCH, with significantly lower in-hospital death rate of inborn (33/802) than out-born (23/223) infants. Compared to non-HWCH, four-fold more neonates in HWCH were under critical care with higher death rate, including most extremely preterm infants. Significant all-death risks were found for the total preterm births in BW < 1,000g, II-III degree of amniotic fluid contamination, Apgar-5 min < 7, and birth defects (BD). For the hospitalized preterm infants, significant in-hospital death risks were found in out-born of HWCH, GA < 32 weeks, Apgar-5 min < 7, BD, necrotizing enterocolitis and ventilation, whereas born in HWCH, antenatal glucocorticoids, cesarean delivery and surfactant use were protective factors against death.Conclusions: The integrated data revealed GA-specific morbidity and mortality on the basis of total preterm births and their hospitalization, demonstrating the efficacy of leading referral center and whole regional perinatal-neonatal network in China. The concept and protocol of our current study should be extended to gain comprehensive understanding in the world-wide campaign for prevention of preterm birth.

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Preterm neuroimaging and neurodevelopmental outcome: a focus on intraventricular hemorrhage, post-hemorrhagic hydrocephalus, and associated brain injury

Cited by 83 publications

References 105 publications

Validity of SyMRI for Assessment of the Neonatal Brain

Validity of SyMRI for Assessment of the Neonatal Brain

Effects of altitude changes on mild‑to‑moderate closed‑head injury in rats following acute high‑altitude exposure

Preterm Morbidity and Mortality by Gestational Age. A Birth Population-Based Study

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