Preterm birth in two urban areas of Ukraine

Monaghan, Susan C.; Little, Ruth E.; Hulchiy, Olesya; Strassner, Howard T.; Gladen, Beth C.

doi:10.1016/s0029-7844(99)00630-4

Cited by 9 publications

(3 citation statements)

References 11 publications

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“…In Kharkiv however, low risk of premature birth (2.1%) could be a result of collecting part of the data (about 12%) at maternity hospitals which were not taking care of mothers with previous preterm birth since such mothers received care at a specialized neonatal hospital. In a study of pregnancy outcome in two urban areas of Ukraine the rate of preterm delivery was 6.6% of singleton live births [42]. This selection bias may be responsible for differing results in the Kharkiv cohort.…”

Section: Discussionmentioning

confidence: 99%

Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations

et al. 2010

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BackgroundEpidemiological studies on the association between maternal exposure to persistent organic pollutants (POPs) and fetal growth alteration report inconsistent findings which weights in favor of additional studies.MethodsBlood samples were collected from interviewed pregnant women in Greenland (572), Kharkiv (611) and Warsaw (258) and were analyzed for CB-153 and p,p'-DDE by gas chromatography-mass spectrometry. Data on birth weight, gestational age and preterm birth were obtained for 1322 singleton live births. We examined the association between natural log-transformed serum POPs concentration and birth weight and gestational age using multiple linear regression and the association with prematurity using logistic regression controlling for potential confounding factors.ResultsThe median serum concentrations of CB-153 and p,p'-DDE were for Inuit mothers 105.6 and 298.9, for Kharkiv mothers 27.0 and 645.4 and for Warsaw mothers 10.7 and 365.2 ng/g lipids, respectively. Increase in CB-153 concentration by one unit on the log scale in Inuit mothers serum was associated with significant decrease in infant birth weight of -59 g and gestational age by -0.2 week. Decreases observed in the cohorts in Kharkiv (-10 g and -0.1 week) and in Warsaw (-49 g and -0.2 week) were not statistically significant. Increase in p,p'-DDE concentration by one unit on the log scale was associated with a statistically significant decrease in infant birth weight of -39.4 g and -104.3 g and shortening of gestational age of -0.2 week and -0.6 week in the Inuit and Warsaw cohorts, respectively. In the Kharkiv cohort decrease in birth weight (-30.5 g) was not significant, however a shortening of gestational age of -0.2 week per increase in p,p'-DDE concentration by one unit on the log scale was of the borderline significance. There was no significant association between CB-153 and p,p'-DDE concentrations and risk of preterm birth however, in all cohorts the odds ratio was above 1.ConclusionsIn utero exposure to POPs may reduce birth weight and gestational age of newborns however, new insights as to why results vary across studies were not apparent.

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Section: Discussionmentioning

confidence: 99%

Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations

et al. 2010

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“…In Ukraine, the low liveborn preterm rate reflects high rates of fetal deaths and deliveries < 37 weeks, conservative policies of resuscitation, and a low rate of medical intervention in pathological pregnancies. These factors result in a lower proportion of births before 37 weeks that are born alive, and hence a lower rate of preterm delivery 15 …”

Section: Discussionmentioning

confidence: 99%

“…Sample selection and recruitment have been described in detail elsewhere 15 . Briefly, Children of Ukraine subjects were drawn from the population of all women diagnosed pregnant in these two geographical sites with LMP between 25 December 1992 and 23 July 1994.…”

Section: Methodsmentioning

confidence: 99%

Risk factors for spontaneous preterm birth in two urban areas of Ukraine

Monaghan

Little

Hulchiy

et al. 2001

Paediatric Perinatal Epid

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The economic, social and health problems faced by former eastern bloc countries after the demise of the Soviet Union are unique in the recent history of Europe. We conducted a study in two urban areas of Ukraine, asking if the traditional predictors of preterm delivery continue to be associated with risk under these conditions. Subjects were pregnant women with last menstrual period (LMP) between 25 December 1992 and 23 July 1994. Self-completed questionnaires and the medical record provided data. We compared 137 spontaneous preterm deliveries with 2,886 full-term births, using all established risk factors for which we had data. Maternal age was the variable most strongly related to preterm birth. Being 18 or less had an odds ratio (OR) of 3.7; being 30+ had an OR of 2.5 relative to the reference group of age 25-29. Placental complications and pre-existing hypertension had ORs of 2.7 and 2.3, respectively, but the confidence interval included 1.0. Low net pregnancy weight gain (less than 10 kg) was significantly associated with preterm birth, but the rate of net weight gain was not. Marital status and educational category were only weakly related. We conclude that although Ukraine faced serious difficulties during its transition to a market economy, these problems did not generally alter the outcome of pregnancy in our sample when the classic risk factors for preterm delivery were present.

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