Preterm Birth and Small-for-Gestational Age Neonates among Prepregnancy Underweight Women: A Case-Controlled Study

Lefizelier, Emelyne; Misbert, Emilie; Brooks, Marion H.; Thuaut, Aurélie Le; Winer, Norbert; Ducarme, Guillaume

doi:10.3390/jcm10245733

Cited by 5 publications

(4 citation statements)

References 27 publications

(47 reference statements)

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“…With regard to the birth of SGA infants, maternal health conditions are of great importance for fetal growth. Several studies have revealed that the delivery of SGA neonates may be attributed to maternal pre-pregnancy underweight and some socioeconomic factors like poor education level [44,45]. The underlying mechanism of SGA may be related to placenta dysfunction and dyslipidemia [46,47].…”

Section: Discussionmentioning

confidence: 99%

A prospective study on maternal periodontal diseases and neonatal adverse outcomes

Wen,

Li,

et al. 2024

AOS

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Objective: It is evident that periodontitis is linked to various adverse pregnancy outcomes. This prospective study explored the potential link of maternal periodontal diseases to neonatal adverse outcomes. Materials and Methods: A total of 193 generally healthy females in their third trimester (34–36 weeks) of pregnancy were enrolled. All subjects received full-mouth periodontal assessment, and the periodontal inflamed surface area (PISA) was calculated. Demographic data, lifestyles and anthropometric measurements of the neonates (e.g., body length and head circumference) were recorded. Herein, small-for-gestational age (SGA) referred to gender- and age-adjusted birth weight below the 10th percentile in line with the standard reference. Multivariable logistic regression analysis and restricted cubic spline were performed for examining the association of periodontal parameters with SGA. Results: There were 8.3% (16/193) of neonates with SGA. Significantly positive correlation existed between the percentage of tooth sites with increased probing depth and an elevated risk of SGA (OR: 1.052; P < 0.05). Yet, the PISA was positively associated with the risk of SGA (OR: 1.002; P < 0.05) as well. No significant link occurred between maternal periodontal status and other neonatal outcome measures. Conclusion: Within the limitations of this study, the findings suggest that there could be a link between maternal periodontal diseases and neonatal adverse outcomes like SGA. Further investigation is required to clarify the current findings and potential implications for promoting maternal oral/periodontal health and newborn health.

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Section: Discussionmentioning

confidence: 99%

A prospective study on maternal periodontal diseases and neonatal adverse outcomes

Wen,

Li,

et al. 2024

AOS

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“…Malnutrition during pregnancy and low pre-pregnancy BMI have significant negative effects on birthweight [ 57 , 58 , 59 ]. Given that approximately 829 million people worldwide are exposed to hunger, this global problem may also have a deleterious effect on pregnant women in some regions and populations.…”

Section: Methodsmentioning

confidence: 99%

Insights into Prevention of Health Complications in Small for Gestational Age (SGA) Births in Relation to Maternal Characteristics: A Narrative Review

Wołejszo

Genowska

Motkowski

et al. 2023

JCM

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Small for gestational age (SGA) births are a significant clinical and public health issue. The objective of this review was to summarize maternal biological and socio-demographic factors and preventive strategies used to reduce the risk of SGA births. A literature search encompassing data from the last 15 years was conducted using electronic databases MEDLINE/PubMed, Google Scholar and Scopus to review risk factors and preventive strategies for SGA. Current evidence shows that primiparity, previous stillbirths, maternal age ≤24 and ≥35 years, single motherhood, low socio-economic status, smoking and cannabis use during pregnancy confer a significant risk of SGA births. Studies on alcohol consumption during pregnancy and SGA birth weight are inconclusive. Beneficial and preventive factors include the “Mediterranean diet” and dietary intake of vegetables. Periconceptional folic acid supplementation, maternal 25-hydroxyvitamin D, zinc and iron levels are partly associated with birth weight. No significant associations between COVID-19 vaccinations and birthweight are reported. A midwifery-led model based on early and extensive prenatal care reduces the risk of SGA births in women with low socio-economic status. Major preventive measures relate to the awareness of modifiable and non-modifiable risk factors of SGA, leading to changes in parents’ lifestyles. These data support that education, monitoring during pregnancy, and implementing preventive strategies are as important as biological determinants in risk reduction of SGA births.

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“…First, given the potential confounding bias, our study used a cohort of motherchild pairs with a one-and-a-half-year follow-up, and only women lacking undisputed high-risk factors for PTB were included in the study. Several studies used retrospective designs to investigate the association between GWG and PTB, which maybe a source of bias [25][26][27]. While most previous studies used statistical methods to correct for research bias caused by other high-risk factors of PTB, we excluded the PTB high-risk group from the beginning of the cohort study to accurately describe the relationship between GWG and PTB.…”

Section: Advantages and Limitationsmentioning

confidence: 99%

The Rate of Gestational Weight Gain are Associated with Preterm Birth in Pregnant Women at Low Risk for Preterm Birth: A Single-Center, Observational Study

Wu¹,

Li²,

Wei³

et al. 2023

Clin. Exp. Obstet. Gynecol.

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Background: Preterm birth (PTB) is the main cause of infant disease and death worldwide. Approximately 70% of neonatal deaths and 36% of infant deaths worldwide are caused by premature birth. Gestational weight gain (GWG) is associated with adverse pregnancy outcomes. This study explored the relationship between the rate of GWG and PTB among pregnant women at low risk of preterm birth. Methods: Our study used a cohort of mother-child pairs with a one-and-a-half-year follow-up from January 2020 to June 2021. We excluded pregnant women with undisputed high-risk factors for PTB and the remaining women were considered the low-risk group. The average rate of GWG was utilized in this research as the measure of GWG. Multivariate logistic regression was used to evaluate the relationship between GWG and PTB among pregnant women at low risk for preterm birth. Results: The final cohort study of mother-child pairs included 3480 pregnant women in the low-risk group. Women with low GWG had a higher possibility of PTB than those with adequate GWG. Comparing underweight women with an adequate GWG rate to underweight women with a low GWG rate, PTB risk increased by 2.52-fold with a low GWG rate. Compared to women with adequate GWG, underweight women with excessive GWG had significantly higher odds of PTB. No significant results were observed for pregnant women classified as overweight or obese. Conclusions: A reasonable GWG during pregnancy can effectively reduce the risk of PTB, especially for pregnant women with low pre-pregnancy body mass index. Low or excessive GWG may lead to an increased risk of PTB.

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Preterm Birth and Small-for-Gestational Age Neonates among Prepregnancy Underweight Women: A Case-Controlled Study

Cited by 5 publications

References 27 publications

A prospective study on maternal periodontal diseases and neonatal adverse outcomes

A prospective study on maternal periodontal diseases and neonatal adverse outcomes

Insights into Prevention of Health Complications in Small for Gestational Age (SGA) Births in Relation to Maternal Characteristics: A Narrative Review

The Rate of Gestational Weight Gain are Associated with Preterm Birth in Pregnant Women at Low Risk for Preterm Birth: A Single-Center, Observational Study

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