Presymptomatic diagnosis of bronchogenic carcinoma associated with bilateral diffuse uveal melanocytic proliferation

Sen, Jyotsna; Clewes, A.; Quah, Sayaun; Hiscott, Paul; Bucknall, R C; Damato, Bertil

doi:10.1111/j.1442-9071.2006.01145.x

Cited by 31 publications

(17 citation statements)

References 10 publications

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“…Though regression has been reported after removal of the underlying cause, 3 in our case, only some of the lesions showed a decrease in size. Duong et al 4 reported the longest survivor of this disorder (4102 months), but their patient underwent bilateral enucleation; our report shows a case of BDUMP with survival of over 4 years and a good visual acuity.…”

Section: Commentscontrasting

confidence: 57%

Long-term survival in a case of bilateral diffuse uveal melanocytic proliferation

Salvo

Prakash

Rennie

et al. 2011

Eye

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It is worth noting that the overall success at the last follow-up for the patients was 79%. It is the probability of success that falls from 66% at 9 months to below 45% at 1 year and beyond. The finding of 63% of the blebs being functional at the last follow up is therefore consistent with the overall success rate. The definition of a well-functioning bleb used was one that is elevated (low to moderately) and diffuse, without any restricting scar, and relatively avascular. The postoperative assessment was done by the same ophthalmologist to ensure consistency.The intraocular pressures of the infants were usually measured at the initial phase of halothane inhalation 1-1.5% when the patients were just sedated. The intraocular pressures of the two eyes determined during the deep phase of anaesthesia were all done preoperatively, and, therefore admittedly, contributed to a relatively lower mean (30.3±8.8) than expected. However, all postoperative measurements were done at the initial phase of halothane inhalation 1-1.5% when the patients were just sedated except two eyes that had the measurements done using Pulsair non-contact tonometer without anaesthesia and in the office setting, but their results were normal.We appreciate the suggestion to exclude intraocular pressures readings taken with Schiotz tonometer in our analysis due to errors associated with its use. However, Schiotz tonometer was the only tool available to us for a period when the Perkins tonometer was faulty. Presently, Schiotz tonometer is no longer in use at our centre.As regards the visual outcome using visual acuity, as indicated in our study, there was paucity of data on postoperative visual acuity and refraction at the last follow-up to make any meaningful statistical analysis. This we acknowledged as a limitation. Conflict of interestThe authors declare no conflict of interest. 2 later described five cardinal signs related to BDUMP: multiple red patches at the level of the RPE, corresponding early hyperfluorescence of these patches on fluorescein angiography, development of multiple pigmented and non-pigmented uveal melanocytic tumors with diffuse thickening of the uveal track, exudative retinal detachment, and rapidly progressive cataracts. Patients affected by BDUMP have a short life expectancy. 2 We, however, report a case of BDUMP, which illustrates that long-term survival can occur despite multiple metastases. Case reportA 62-year-old man was referred for cataract surgery to both eyes. At presentation, his right visual acuity was 0.40 logMAR and left visual acuity was 0.80 logMAR. He had a past medical history of transitional cell carcinoma of the bladder, with multiple metastases treated with surgical excision and chemotherapy. At preoperative review, his vision decreased to hand movements OD and counting fingers OS due to rapid progression of the cataracts. Postoperative examination revealed BDUMP (Figure 1). Further investigation discovered new metastases. Four years later, his visual acuity is 0.12 logMAR OD and 0.0 logMAR OS and so...

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Section: Commentscontrasting

confidence: 57%

Long-term survival in a case of bilateral diffuse uveal melanocytic proliferation

Salvo

Prakash

Rennie

et al. 2011

Eye

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“…1 Since then, it has been described as a paraneoplastic syndrome associated with distal cancers. [1][2][3][4][5][6][7][8] The uveal melanocytic proliferation is a sine qua non of this entity; and in the past, progressive vision loss has been the rule. Along with others, we have recently shown that plasma exchange improves the prognosis.…”

Section: Resultsmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8] It is associated with thickening of the uvea because of hyperplastic proliferation of benign uveal melanocytes. [1][2][3][4][5][6][7][8] Recent data show that it can be ameliorated by plasma exchange, suggesting that there is a proliferation-inducing factor in the plasma. 7,8 A recent study has shown that plasma from patients with BDUMP contains an IgG that causes cultured melanocytes to proliferate and elongate, which we have termed cultured melanocyte elongation and proliferation factor (CMEP factor).…”

Section: Introductionmentioning

confidence: 99%

Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation

Pulido

Flotte

Raja

et al. 2013

Eye

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Aim The goal of this case report is to describe the dermatologic and conjunctival findings in a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), a paraneoplastic syndrome usually associated with gynecologic cancers. There is little information about other dermatologic melanocytic findings in these patients. Methods Histologic and fluorescent in situ hybridization (FISH) analysis of three separate skin biopsies, one of which was separated by 21 months from the others, were performed in a 71-year-old patient with BDUMP to assess for histologic and chromosomal abnormality. Conjunctival histologic evaluation was also done. Results Dermal melanocytic proliferation was seen in each specimen. The cells were spindle type with mitotic activity. FISH analysis showed a normal copy of chromosomes. The conjunctival sample also showed normal FISH analysis. Conclusion BDUMP is associated with multifocal dermal and conjunctival melanocytic proliferation.

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“…It was previously noted that palmar fasciitis associated with cancer progresses much more rapidly than in Dupuytren's disease (16). In some cases, the resection of the underlying cancer may stop the progression of the symptoms and relieve the symptoms (8,18,19). Only rarely do glucocorticoids produce a favorable effect (18,(20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

Fallopian Tube Cancer with Palmar Fibromatosis or Fasciitis without Polyarthritis

et al. 2015

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A 64-year-old Japanese woman had rapidly progressing bilateral palmar contracture associated with severe pain on both palms over the previous 8 weeks, without a history of arthritis in any joints. We suspected palmar fibromatosis or fasciitis without polyarthritis. Because palmar fibromatosis is known to be associated with cancer, we performed cancer screening and the patient was subsequently diagnosed with fallopian tube cancer. This is the first case report of palmar fibromatosis or fasciitis without polyarthritis associated with fallopian tube cancer. The characteristic rapid progression of palmar contracture is a key finding that suggests the potential existence of a malignancy.

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Presymptomatic diagnosis of bronchogenic carcinoma associated with bilateral diffuse uveal melanocytic proliferation

Cited by 31 publications

References 10 publications

Long-term survival in a case of bilateral diffuse uveal melanocytic proliferation

Long-term survival in a case of bilateral diffuse uveal melanocytic proliferation

Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation

Fallopian Tube Cancer with Palmar Fibromatosis or Fasciitis without Polyarthritis

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