Prestorage leukocyte reduction with in-lin filtration system for whole blood(Sepacell Integra MAP): Evaluation of system efficiency and blood products.

Estimation of the infectious viral load required for transfusion‐transmitted human T‐lymphotropic virus type 1 infection (TT‐HTLV‐1) and of the effectiveness of leukocyte reduction in preventing TT‐HTLV‐1

“…). The number of leucocytes per unit of RCC is reportedly between 1 × 10 8 and 1 × 10 9 before LR . We estimated that when the number of leucocytes per unit of RCC is 1 × 10 8 before LR, non‐LR‐RCC units that cause TT‐HTLV‐1 contain ≥9 × 10 4 (0·09% of 1 × 10 8 ) cells with integrated HTLV‐1 provirus (Fig.…”

“…In >99% of the blood components supplied from JRC blood centres, residual leucocyte numbers are within acceptable limits (1 × 10 6 per unit) . Furthermore, in >95% of blood component units, the actual number of residual leucocytes is <1 × 10 5 , even in whole blood which contains a larger number of leucocytes than individual components .…”

Electrostatic field can preserve red blood cells in stored blood preparations

“…Proteases or hydroxy radicals derived from leukocytes may be one of the causative factors of hemolysis [10]. Leukocytes have already been reduced in MAP-CRC [11]. In one of our previous studies, the addition of haptoglobin, a free hemoglobin scavenger, or ulinastatin, a protease inhibitor, decreased hemolysis in the stored MAP-CRC [8].…”