Prestin autoantibodies screening in idiopathic sudden sensorineural hearing loss

Tovi, Hodaya; Ovadia, Haim; Eliashar, Ron; M, de Jong; Gross, Menachem

doi:10.1016/j.anorl.2017.11.013

Cited by 11 publications

(12 citation statements)

References 12 publications

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“…However, prestin concentrations were lower after than before treatment in 60% ISSHL patients who responded to treatment, although the difference was not statistically significant. Another study, in which anti-prestin autoantibodies were analyzed by ELISA in plasma of SSNHL patients, found no statistically significant differences [ 60 , 61 ].…”

Section: Biomarkers In Ssnhlmentioning

confidence: 99%

Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss

Doo

Kim

et al. 2020

IJMS

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Sudden sensorineural hearing loss (SSNHL) is a medical emergency, making detailed examination to determine possible causes and early treatment important. However, etiological examinations in SSNHL do not always reveal a cause, and several factors have been found to affect treatment outcomes. Various studies are being performed to determine the prognosis and effects of treatment in patients who experience sudden hearing loss, and to identify biomarkers associated with this condition. Embase, PubMed, and the Cochrane database were searched using the key words SSNHL, prognostic, and biomarker. This search identified 4 articles in Embase, 28 articles in PubMed, and 36 in the Cochrane database. Of these 68 articles, 3 were duplicates and 37 were unrelated to the research topic. After excluding these articles, the remaining 28 articles were reviewed. Factors associated with SSNHL were divided into six categories: metabolic, hemostatic, inflammatory, immunologic, oxidative, and other factors. The associations between these factors with the occurrence of SSNHL and with patient prognosis were analyzed. Low monocyte counts, low neutrophil/lymphocyte ratio (NLR) and monocyte/high-density lipoproteins (HDL) cholesterol ratio (MHR), and low concentrations of fibrinogen, platelet glycoprotein (GP) IIIa, and TNF-α were found to be associated with good prognosis. However, these factors alone could not completely determine the onset of and recovery from SSNHL, suggesting the need for future basic and clinical studies.

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Section: Biomarkers In Ssnhlmentioning

confidence: 99%

Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss

Doo

Kim

et al. 2020

IJMS

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“…Building on this idea, prestin blood levels have been measured in several rodent and human studies with NIHL, ISSHL, or drug-induced HL. The rationale for these studies is that these types of SNHL seem to be associated with OHC damage ( Ryan et al 2016 ; Tovi et al 2019 ). ELISA is the only blood prestin detection method that has been identified in the present review (Table 1 and Table in Supplemental Digital Content 1, http://links.lww.com/EANDH/A798 ).…”

Section: Discussionmentioning

confidence: 99%

“…Apart from cochlear prestin, circulating prestin has also been observed in the blood of animals and humans with or without HL ( Parham 2015 ; Dogan et al 2018 ; Tovi et al 2019 ). Its presence in the blood has been detected by means of enzyme-linked immunosorbent assay (ELISA) and could be explained either by its small size (80 kDa), which may allow crossing of the blood-labyrinthine barrier or by its engulfment by phagosomes after OHC apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review

et al. 2021

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“…However, the difference was not statistically significant. 8 Another study, 1 in which anti-prestin autoantibodies were analysed by enzyme-linked immunosorbent assay in the plasma of idiopathic sudden SNHL patients, found no statistically significant differences between prestin autoantibodies and demographic or audiological parameters.…”

Section: Introductionmentioning

confidence: 98%

“…3 A number of inner-ear antigens have been suggested as targets for autoantibodies: type II collagen, beta-actin, cochlin, beta-tectorin and prestin. 1 Prestin, which is found in the lateral plasma membrane of outer hair cells, plays a central role in cochlear sensitivity and tuning. 4 Damage to outer hair cells is one of the earliest events that lead to hearing loss.…”

Section: Introductionmentioning

confidence: 99%

Assessment of prestin level changes as an inner-ear biomarker in patients with idiopathic sudden sensorineural hearing loss

2021

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Objective To assess the correlation of serum prestin level and audiological findings in adults with idiopathic sudden sensorineural hearing loss. Methods Audiometry and serum prestin measurements were performed at study entry (T0), at day 14 (end of treatment, T1) and at day 30 (T2). Results A total of 25 idiopathic sudden sensorineural hearing loss patients and 25 healthy adults were included. The geometric mean prestin level in the case and control groups at T0 was 227.7 pg/ml and 130.5 pg/ml, respectively. The geometric mean prestin level in the case group demonstrated a downward trend at T1 and T2 (214.0 pg/ml and 180.1 pg/ml, respectively; p < 0.001). Of 17 patients with high baseline prestin levels (over 150 pg/ml), prestin levels tended to decrease in 11 patients, and 5 of them (45.5 per cent) showed good recovery. Conclusion The prestin concentrations increased in two-thirds of patients with idiopathic sudden sensorineural hearing loss. Future work is recommended to determine the location of injury.

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Prestin autoantibodies screening in idiopathic sudden sensorineural hearing loss

Cited by 11 publications

References 12 publications

Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss

Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss

Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review

Assessment of prestin level changes as an inner-ear biomarker in patients with idiopathic sudden sensorineural hearing loss

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