Pressurized liquid extraction of berberine and aristolochic acids in medicinal plants

Ong, Eng-Shi; Woo, Soo-On; Yong, Yuk-Lin

doi:10.1016/s0021-9673(00)00914-6

Cited by 110 publications

(71 citation statements)

References 17 publications

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“…However, Guanmutong, Qingmuxiang and Guangfangji have been cancelled (State Food andDrug Administration, 2003, 2004) because the content of aristolochic acids in these three drugs is high enough to cause aristolochic acid nephropathy (AAN). AAN has been reported in some countries, including Belgium (Vanherweghem et al, 1993), England (Lord et al, 1999), Japan (Tanaka et al, 1997), and China (Liu and Zeng, 1994;Ma, 1998 Shang et al, 2000), thin layer chromatography scanning (TLCS; Chen et al, 1994;Cui et al, 2001), high-performance liquid chromatography (HPLC; Liu and Wang, 1990;Hashimoto et al, 1999;Ong et al, 2000;Schaneberg et al, 2002;Kawamura et al, 2003), liquid chromatography-electrospray mass spectrometry (LC/MS; Kite et al, 2002;Chan et al, 2003;Jong et al, 2003;Ioset et al, 2003), and capillary zone electrophoresis (CZE; Ong and Woo, 2001;Li et al, 2004b). However, most of these reports focused on the determination of AA-I or AA-I and AA-II, while no report on the determination of other AAs was found except that the contents of AA-I, AA-II, AA-III, AA-IIIa, AA-IVa, AA-VIIa and AA-E in leaves of Aristolochia debilis were given after HPLC analysis (Nishida and Fukami, 1989).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of five aristolochic acids and two aristololactams in Aristolochia plants by high‐performance liquid chromatography

Zhang

Wang

Shang

et al. 2005

Biomedical Chromatography

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An HPLC method was developed for the simultaneous determination of five aristolochic acids (AAs) and two aristololactams (ALs) in the following six Chinese drugs derived from Aristolochia species. Samples were analyzed on a C 18 column with acetonitrile and 3.7 mM phosphoric acid buffer gradient elution, detected at 260 nm. Assay was linear over the range (µg/mL) 0.386-38.6 for aristolochic acid Va, 0.632-63.2 for aristolochic acid IVa, 0.200-20.0 for 9-hydroxy aristolochic acid I, 0.352-35.2 for aristololactam II, 0.296-29.6 for aristolochic acid II, 0.274-27.4 for aristololactam I and 3.12-312 for aristolochic acid I. Average recoveries (%) of samples were 102.0, 95.9, 99.2, 102.2, 97.2, 97.1 and 97.8 for these seven constituents, respectively. The detection limit and retention time for the seven constituents ranged from 10.0 to 15.8 ng/mL and from 12 to 21 min. As

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of five aristolochic acids and two aristololactams in Aristolochia plants by high‐performance liquid chromatography

Zhang

Wang

Shang

et al. 2005

Biomedical Chromatography

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“…Since PFE uses less solvent in a shorter period of time, is automated, and involves retaining the sample in an oxygen and light-free environment, it has the potential to be a powerful tool in the nutraceutical industry. Recent applications have demonstrated the advantage of PFE for the extraction of natural products from plant materials [3][4][5][6][7][8][9]. Other biological applications include the extraction of fatty acids from plant and animal matrices [10] and the determination of zearalenone mycotoxin in corn * Correspondence author.…”

Section: Introductionmentioning

confidence: 99%

Pressurized fluid extraction of carotenoids from Haematococcus pluvialis and Dunaliella salina and kavalactones from Piper methysticum

Denery

Dragull

Tang

et al. 2004

Analytica Chimica Acta

147

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Pressurized fluid extraction (PFE) was examined as an alternative technology for the extraction of carotenoids in the green algae Haematococcus pluvialis and Dunaliella salina and kavalactones in Piper methysticum. The extraction process was optimized by varying the key extraction factors of solvent, sample-solvent ratio, temperature, and time. The selectivity and efficiency of extraction parameters were determined with high performance liquid chromatography (LC) and LC-mass spectrometry (LC-MS). Results showed that PFE utilization of conventional solvents under controlled temperature and pressure in an oxygen and light-free environment could result in the use of less solvent in a shorter period of time. PFE showed higher or equal extraction efficiencies as compared with traditional solvent extractions while maintaining the integrity of chemical components. PFE showed high potential for extraction of natural products and nutraceuticals, particularly labile and light sensitive chemicals.

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“…Aristolochic acids (AAs) are a mixture of nitrophenanthrene carboxylic acid derivatives found primarily in the genus Aristolochia (Ong et al, 2000). Major components of AAs include aristolochic acid I (8-methoxy-6-nitro-phenanthro (3,4-d)-1,3-dioxolo-5-carboxylic acid, AAI) and aristolochic acid II (6-nitro-phenanthro (3,4-d)-1,3-dioxolo-5-carboxylic acid, AAII) that differ by a methoxy group (Fig.…”

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confidence: 99%

Investigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in Rats

et al. 2007

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ABSTRACT:The metabolic activation of aristolochic acids (AAs) that have been demonstrated to be mutagenic and carcinogenic was investigated. In vitro metabolism study indicated that AAs were metabolized to N-hydroxyaristolactam, which could be either reduced to aristolactams or rearranged to 7-hydroxyaristolactams via the Bamberger rearrangement. In vivo metabolism study is important because the intermediates (aristolactam-nitriumion) of the nitroreduction process are thought to be responsible for the carcinogenicity of AAs. Liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry (MS/MS) were applied to the analyses of a series of positional isomers of hydroxyaristolactams in rat urine samples after the in vivo study of AAs. Three hydroxylated metabolites of aristolactam II and two hydroxylated metabolites of aristolactam I were identified. The structures of the positional isomers were elucidated from the interpretation of MS/MS spectra and theoretical calculations. In addition, several new metabolites were detected in the rat urine by high-resolution mass spectrometry and MS/MS, including those from the decarboxylation of AAs and the conjugations of acetylation, glucuronidation, and sulfation of aristolochic acid Ia.

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Pressurized liquid extraction of berberine and aristolochic acids in medicinal plants

Cited by 110 publications

References 17 publications

Simultaneous determination of five aristolochic acids and two aristololactams in Aristolochia plants by high‐performance liquid chromatography

Simultaneous determination of five aristolochic acids and two aristololactams in Aristolochia plants by high‐performance liquid chromatography

Pressurized fluid extraction of carotenoids from Haematococcus pluvialis and Dunaliella salina and kavalactones from Piper methysticum

Investigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in Rats

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