Pressure programming in supercritical fluid chromatography

Smith, Richard D.; Chapman, Elaine G.; Wright, Bob W.

doi:10.1021/ac00291a019

Cited by 45 publications

(24 citation statements)

References 26 publications

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“…Experiments were performed at discrete pressures, which are indicated by the vertical lines in Figure 4. In actual pressure-programmed analysis, the linear velocities would be higher and dependent on the position in the column, owing to "compression velocity" contributions as described by Smith (14). Figure 5 clearly illustrates the ability of the dual-restrictor system to control the velocity during pressure-programmed SFC.…”

Section: Resultsmentioning

confidence: 98%

Flow rate control in pressure‐programmed capillary supercritical fluid chromatography

Janssen

Rijks

Cramers

1990

J Microcolumn Separations

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Abstract. A versatile and simple system is described that allows variation of the column flow rate in open-tubular capillary supercritical fluid chromatography using both on-column and postcolumn detection. The system is based on column-effluent splitting in a low-dead-volume T piece at the column exit just before detection. The flow is split into two streams. One stream is fed to a flame ionization detector, and the second is used to control the overall mass flow through the column. Flow through linear restrictors is studied as a function of the pressure drop over the restrictor at ambient temperature. We derived a simple relationship from this study that quantifies the flow rate characteristics of the dual-restrictor system as a function of the column pressure and the restrictor back pressure.The variable-flow system was employed to control independently column pressure and mass flow rate in pressure-programmed analysis. Resolution in flow-controlled pressure-programmed elution was shown to be superior to that achieved in fixed-restrictor systems. Furthermore, the applicability of the system as a convenient means of measuring Van Deemter curves and diffusion coefficients is demonstrated.

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Section: Resultsmentioning

confidence: 98%

Flow rate control in pressure‐programmed capillary supercritical fluid chromatography

Janssen

Rijks

Cramers

1990

J Microcolumn Separations

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“…The amount of pressure controls the balance between solubility and selectivity. In early experiments, particularly with capillary chromatography, the most frequently employed operating variable was a pressure gradient, which has been approached from both theoretical [21,22] and practical viewpoints [23]. These gradients supplied gradual eluent strength throughout the run [24].…”

Section: Improvement Of Purity Of Epa-ee and Dha-ee By Programmed Prementioning

confidence: 99%

Separation of single component of EPA and DHA from fish oil using silver ion modified molecular sieve 13X under supercritical condition

Hao¹,

Cao²,

Hur³

2008

Journal of Industrial and Engineering Chemistry

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“…Since increasing the mobile phase density can decrease the retention factor, pressure programming is often used to speed up the elution of highly retained components in complex samples and, thus, to increase the separation number per unit time in SFC [11]. Programming can also improve peak shape and detection for solutes with high retention.…”

Section: Effect Of Pressure Program On Separationmentioning

confidence: 99%

Fast supercritical fluid chromatography of polymers using packed capillary columns

Yee

Lee

2000

Chromatographia

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SummaryFast separations of perfluorinated polyethers and polymethylsiloxanes that are composed of 50-80 ohgomers were demonstrated in packed capillary column supercritical fluid chromatography (SFC) using a carbon dioxide mobile phase. Separations were accomplished within 10 min using a 13 cm x 250 I~m i.d. column packed with 2 I~m porous octadecyl bonded silica (ODS) particles. Effects of particle diameter of the packing material and pressure programming on separation were investigated, and packed column SFCwas compared with open tubular column SFC. Results show that as the particle diameter was decreased from 5 to 3 to 2 I~m and the column length was reduced from 85 to 43 to 13 cm, the separation time could be reduced from 70 to 20 to 10 min while still maintaining similar separation (resolution). Short colu mns packed with small porous particles are very suitable for fast SFC separations of polymers.

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Pressure programming in supercritical fluid chromatography

Cited by 45 publications

References 26 publications

Flow rate control in pressure‐programmed capillary supercritical fluid chromatography

Flow rate control in pressure‐programmed capillary supercritical fluid chromatography

Separation of single component of EPA and DHA from fish oil using silver ion modified molecular sieve 13X under supercritical condition

Fast supercritical fluid chromatography of polymers using packed capillary columns

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